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Nasopharyngeal Carcinoma Immunotherapy: Current Strategies and Perspectives

  • Corey Smith
  • Rajiv Khanna
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 778)

Abstract

Recent success in treating Epstein-Barr virus (EBV)-associated posttransplant lymphoproliferative disorder (PTLD) using cytotoxic T-cell (CTL) based immunotherapy has led to interest in the development of CTL-based immunotherapy to treat other EBV-associated malignancies, including Nasopharyngeal carcinoma (NPC). However unlike PTLD, which arises in immunosuppressed individuals following transplant, NPC can arise in immunocompetent individuals, expresses a limited array of EBV antigens that are poorly immunogenic, and appear to suppress the function of these T cells either directly or through the expansion of regulatory T cells. There is therefore a unique set of problems that need to be addressed in order to optimise CTL-therapy for the effective treatment of NPC.

Keywords

Nasopharyngeal Carcinoma Adoptive Immunotherapy Modify Vaccinia Ankara Metastatic Nasopharyngeal Carcinoma Polyepitope Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Corey Smith
    • 1
  • Rajiv Khanna
    • 1
  1. 1.Australian Centre for Vaccine Development, Tumour Immunology Laboratory, Division of Infectious Diseases and ImmunologyQueensland Institute of Medical ResearchBrisbaneAustralia

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