Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective

Conference paper

DOI: 10.1007/978-1-4614-5915-6_4

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 772)
Cite this paper as:
Rivera L., Pandika M., Bergers G. (2014) Escape Mechanisms from Antiangiogenic Therapy: An Immune Cell’s Perspective. In: Koumenis C., Hammond E., Giaccia A. (eds) Tumor Microenvironment and Cellular Stress. Advances in Experimental Medicine and Biology, vol 772. Springer, New York, NY

Abstract

Neovascularization, the formation of new blood vessels, has become a well-established hallmark of cancer. Its functional importance for the manifestation and progression of tumors has been validated further by the beneficial therapeutic effects of angiogenesis inhibitors, most notably those targeting vascular endothelial growth factor signaling pathways. However, with the transient and short-lived nature of patient response, it has become evident that tumors have the ability to adapt to the pressures of vascular growth restriction. Observations made both in the clinic and at the bench suggest the existence of several escape mechanisms that either reestablish neovascularization in tumors or change tumor behavior to enable propagation and progression without obligate neovascularization. Some of these bypass mechanisms are regulated by low oxygen conditions (hypoxia) caused by therapy-induced vessel regression. Induction of hypoxia and hypoxia-inducible factors regulate a wide range of tumor-promoting pathways, including those of neovascularization, that can upregulate additional proangiogenic factors and drive the recruitment of various bone marrow–derived cells that have the capacity to express proangiogenic factors or directly contribute to neovasculature.

Keywords

Cancer Antiangiogenic therapy Resistance Innate immune cells Macrophages Myeloid-derived suppressor cells (MDSCs) Neovascularization 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Lee Rivera
    • 1
    • 2
  • Melissa Pandika
    • 1
    • 2
  • Gabriele Bergers
    • 1
    • 2
    • 3
    • 4
  1. 1.Departments of Neurological SurgeryUniversity of California, Helen Diller Family Cancer Research CenterSan FranciscoUSA
  2. 2.Brain Tumor Research CenterUniversity of California, Helen Diller Family Cancer Research CenterSan FranciscoUSA
  3. 3.AnatomyUniversity of California, Helen Diller Family Cancer Research CenterSan FranciscoUSA
  4. 4.UCSF Comprehensive Cancer CenterUniversity of California, Helen Diller Family Cancer Research CenterSan FranciscoUSA

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