Locally Advanced Breast Cancer

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Abstract

Locally advanced disease requires multimodality therapy that includes surgery, radiotherapy, and chemotherapy. Radiotherapy plays an important role in the management of locally advanced breast cancer. Postoperative radiotherapy significantly reduces the risk of locoregional failure and improves disease-free survival (DFS). Three important randomized clinical trials have shown a significant benefit in local control, DFS, and overall survival (OS) with the addition of radiation therapy for patients with stages II and III breast cancer. In addition to these data, the Early Breast Cancer Trialists’ Collaborative Group meta-analysis concluded that one breast cancer death over the next 15 years would be avoided for every four local recurrences avoided. In conclusion, radiation therapy has an important role and all guidelines recommend radiotherapy as a standard treatment in the management of locally advanced disease.

Keywords

Overall Survival Advanced Breast Cancer Inflammatory Breast Cancer Breast Cancer Death Positive Axillary Lymph Node 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Radiation OncologyAkdeniz UniversityAntalyaTurkey

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