The Discovery of GW Bodies

Chapter
Part of the Advances in Experimental Medicine and Biology book series (volume 768)

Abstract

Human autoantibodies were a key to the discovery of GW bodies and their integral protein, GW182. This publication marks the tenth anniversary of the discovery of GW182. As it turns out, the discovery of GW182 was quite timely because it coincided with the elucidation of the RNA interference (RNAi) pathway, which is now known to have a major role in post-transcriptional gene regulation. Following our publication of the essential features of GW182 in 2002, laboratories from around the world began investigations that led to the elucidation of the role of GW182 in RNAi and other pathways of mRNA processing and degradation. This chapter reviews the discovery of GW182 and the description of GWB and some of the observations that followed that still remain to be elucidated.

Notes

Acknowledgments

The authors would like to acknowledge the efforts and expertise of ­numerous colleagues, collaborators, trainees and technologists.

Trainees: Dr. T. Eystathioy, Dr. Z. Yang, Dr. A. Jakymiw, Dr. S. Lian, Dr. S. Li, Dr. J. Moser, Dr. K. Pauley, Dr. L. Luft, Dr. R. Bhanji, K. Griffith, Dr. L. Stinton, Dr. K. Takeuchi.

Collaborators: Drs. D. Zochodne, M. Woods, J. Keene, S. Tenenbaum, B. Séraphin, N. Cougot, N. Kedersha, D. Bloch, L.E.C. Andrade, M. Mahler, M. Satoh, R. Mydlarski, L. Browder.

Technologists: John Hamel, Meifeng Zhang, Haiyan Hou, Maggie Lin, Jane Yang, Carol Peebles.

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyUniversity of CalgaryCalgaryCanada
  2. 2.Department of Oral Biology, Health Science CenterUniversity of FloridaGainesvilleUSA

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