Relationship of GW/P-Bodies with Stress Granules

Chapter
Part of the Advances in Experimental Medicine and Biology book series (volume 768)

Abstract

Whereas P-bodies are intimately linked to the cytoplasmic RNA decay machinery, stress granules harbor stalled translation initiation complexes that accumulate upon stress-induced translation arrest. In this Chapter, we reflect on the relationship between P-bodies and stress granules. In mammalian cells, the two structures can be clearly distinguished from each other using specific protein or RNA markers, but they also share many proteins and mRNAs. While the formation of P-bodies and stress granules is coordinately triggered by stress, their assembly appears to be regulated independently by different pathways. Under certain types of stress, P-bodies frequently dock with stress granules, and overexpressing certain proteins that localize to both structures can cause P-body/stress granule fusion. Currently available data suggest that these self-assembling compartments are controlled by flux of mRNAs within the cytoplasm, and that their assembly mirrors the translation and degradation rates of their component mRNAs.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Helmholtz Junior Research Group Posttranscriptional Control of Gene ExpressionGerman Cancer Research Center (DKFZ), DKFZ-ZMBH AllianceHeidelbergGermany
  2. 2.Division of Rheumatology, Immunology and AllergyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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