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Treatment of Resistant Bacterial Infections in Children: Thinking Inside and Outside the Box

  • Gilat Livni
  • Shai AshkenaziEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 764)

Abstract

Antimicrobial resistance of bacteria causing pediatric infections has become more common and complicated in recent years. Although formerly confined to hospital settings, multi-drug resistant bacteria now also cause community-acquired infections. Treatment of infections caused by resistant pathogens is difficult, necessitating thinking both inside and outside the box. Determination of the precise minimal inhibitory concentration (MIC) is often crucial for selecting the most appropriate antibiotics, their doses, and use of prolonged infusions. For some multiply-resistant bacteria, off-label use of antibiotics, sometimes with no evidence from controlled studies (“salvage therapy”) is unavoidable.

Keywords

Minimal Inhibitory Concentration Infective Endocarditis Bacterial Meningitis Septic Arthritis Necrotizing Fasciitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Professor of Pediatrics, Sackler Faculty of MedicineSchneider Children’s Medical CenterPetach TikvaIsrael

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