Nanotechnology to Prevent Electron Transfer

  • Sandro Carrara
Chapter

Abstract

We saw in  Chap. 5 different mechanisms of molecular assembly onto surfaces. These mechanisms also play a role in molecular assembly onto Bio/CMOS surfaces. In this chapter, we will show how to use DNA short oligonucleotides or antibodies ( Chap. 3) to develop Bio/CMOS interfaces to sense DNA hybridization or to provide antigen detection. The chapter also shows how different kinds of adsorption mechanisms and different kinds of DNA monolayers produce different Bio/CMOS interfaces with completely different electrical behaviors. In particular, the chapter shows how to use special alkanethiols to improve the quality of these probe surfaces on the nanoscale. We will see that the nanoscale quality of the Bio/CMOS interface is so important that, in some cases, this means we can have the sensing or if we fail on that.

Keywords

Constant Phase Element Precursor Film Parallel Resistance Mercaptoundecanoic Acid Probe Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Further Reading

  1. 1.
    Kambhampati D (ed) (2004) Protein microarray technology. Wiley, San FranciscoGoogle Scholar
  2. 2.
    Wittmann C (Ed) (2005) Immobilisation of DNA on chips (vols. I and II). Springer, BerlingGoogle Scholar
  3. 3.
    Templin MF, Stoll D, Schrenk M, Traub PC, Vöhringer CF, Joos TO (2002) Protein microarray technology. Trends Biotechnol 20:160–166CrossRefGoogle Scholar
  4. 4.
    Berggren C, Stalhandske P, Brundell J, Johnansson G (1999) A feasibility study of a capacitive biosensor for direct detection of DNA hybridization. Electroanalysis 11:156–160CrossRefGoogle Scholar
  5. 5.
    Carrara S, Gürkaynak FK, Guiducci C, Stagni C, Benini L, Leblebici Y, Samorì B, De Micheli G (2007) Interface layering phenomena in capacitance detection of DNA with biochips. Sensor Trans J 76:969–977Google Scholar
  6. 6.
    Vikholm-Lundin I, Auer S, Munter T, Fiegl H, Apostolidou S (2009) Hybridization of binary monolayers of single stranded oligonucleotides and short blocking molecules. Surf Sci 603:620–624CrossRefGoogle Scholar
  7. 7.
    Vikholm-Lundin I, Piskonen R (2008) Binary monolayers of single-stranded oligonucleotides and blocking agent for hybridization. Sensor Actuator B 134:189–192CrossRefGoogle Scholar
  8. 8.
    Carrara S, Cavallini A, Leblebici Y, De Micheli G, Bhalla V, Valle F, Samorì B, Benini L, Riccò B, Vikholm-Lundin I, Munter T (2010) Capacitance DNA bio-chips improved by new probe immobilization strategies. Microelectron J 41:711–717CrossRefGoogle Scholar
  9. 9.
    Mirsky VM, Riepl M, Wolfbeis OS (1997) Capacitive monitoring of protein immobilization and antigen–antibody reactions on monomolecular alkylthiol films on gold electrodes. Biosens Bioelectron 12:977–989CrossRefGoogle Scholar
  10. 10.
    Harder P, Grunz M, Dahint R, Whiteside GM (1998) Molecular conformation in Oligo(ethylene glycol)-terminated self –assembled monolayers on gold and silver surfaces determines their ability to resist protein adsorption. J Phys Chem B 102:426–436CrossRefGoogle Scholar
  11. 11.
    Carrara S, Bhalla V, Stagni C, Samorì B (2009) Nanoscale film structure related to capacitive effects in ethylene-glycol monolayers. Surf Sci 603:L75–L77CrossRefGoogle Scholar
  12. 12.
    Carrara S, Benini L, Bhalla V, Stagni C, Ferretti A, Cavallini A, Riccò B, Samorì B (2009) New insights for using self-assembly materials to improve the detection stability in label-free DNA-chip and immuno-sensors. Biosens Bioelectron 24:3425–3429CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sandro Carrara
    • 1
  1. 1.Faculties Sciences et Techniques de l’Ingénieur and Informatique et Communications Labo. Systèmes Intégrés (LSI)LausanneSwitzerland

Personalised recommendations