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HIV-Derived Vectors for Gene Therapy Targeting Dendritic Cells

  • Maura Rossetti
  • Mariangela Cavarelli
  • Silvia Gregori
  • Gabriella Scarlatti
Chapter
Part of the Advances in Experimental Medicine and Biology book series (volume 762)

Abstract

Human immunodeficiency virus type 1 (HIV-1)-derived lentiviral vectors (LV) have the potential to mediate stable therapeutic gene transfer. However, similarly to other viral vectors, their benefit is compromised by the induction of an immune response toward transgene-expressing cells that closely mimics antiviral immunity. LV share with the parental HIV the ability to activate dendritic cells (DC), while lack the peculiar ability of subverting DC functions, which is responsible for HIV immune escape. Understanding the interaction between LV and DC, with plasmacytoid and myeloid DC playing fundamental and distinct roles, has paved the way to novel approaches aimed at regulating transgene-specific immune responses. Thanks to the ability to target either DC subsets LV might be a powerful tool to induce immunity (i.e., gene therapy of cancer), cell death (i.e., in HIV/AIDS infection), or tolerance (i.e., gene therapy strategies for monogenic diseases). In this chapter, similarities and differences between the LV-mediated and HIV-mediated induction of immune responses, with specific focus on their interactions with DC, are discussed.

Keywords

Dendritic Cell Human Dendritic Cell Gene Therapy Approach Therapeutic Gene Transfer Transfer Vector Construct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Maura Rossetti
    • 1
  • Mariangela Cavarelli
    • 2
  • Silvia Gregori
    • 1
  • Gabriella Scarlatti
    • 2
  1. 1.Division of Regenerative Medicine, Stem Cells, and Gene TherapySan Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), San Raffaele Scientific InstituteMilanItaly
  2. 2.Division of Immunology, Transplant, and Infectious Diseases, Viral Evolution and Transmission UnitSan Raffaele Scientific InstituteMilanItaly

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