3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth
We present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.
KeywordsVascular Endothelial Growth Factor Wall Shear Stress Vascular Endothelial Growth Factor Level Vascular Network Multiscale Model
HMB, MRO and HP acknowledge financial support by the Marie Curie Network MMBNOTT (Project No. MEST-CT-2005-020723). RAG and PKM acknowledge partial support from NIH/NCI grant U54CA143970. HP, AL and MR thank the BMBF—Funding Initiative FORSYS Partner: “Predictive Cancer Therapy”. In vivo window chamber work was funded in part by Moffitt Cancer Center PS-OC NIH/NCI U54CA143970. This publication was based on work supported in part by Award No. KUK-C1-1013-04, made by King Abdullah University of Science and Technology (KAUST).
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