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3D Multiscale Modelling of Angiogenesis and Vascular Tumour Growth

  • H. PerfahlEmail author
  • H. M. Byrne
  • T. Chen
  • V. Estrella
  • T. Alarcón
  • A. Lapin
  • R. A. Gatenby
  • R. J. Gillies
  • M. C. Lloyd
  • P. K. Maini
  • M. Reuss
  • M. R. Owen
Chapter
Part of the Bioanalysis book series (BIOANALYSIS, volume 2)

Abstract

We present a three-dimensional, multiscale model of vascular tumour growth, which couples nutrient/growth factor transport, blood flow, angiogenesis, vascular remodelling, movement of and interactions between normal and tumour cells, and nutrient-dependent cell cycle dynamics within each cell. We present computational simulations which show how a vascular network may evolve and interact with tumour and healthy cells. We also demonstrate how our model may be combined with experimental data, to predict the spatio-temporal evolution of a vascular tumour.

Keywords

Vascular Endothelial Growth Factor Wall Shear Stress Vascular Endothelial Growth Factor Level Vascular Network Multiscale Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

HMB, MRO and HP acknowledge financial support by the Marie Curie Network MMBNOTT (Project No. MEST-CT-2005-020723). RAG and PKM acknowledge partial support from NIH/NCI grant U54CA143970. HP, AL and MR thank the BMBF—Funding Initiative FORSYS Partner: “Predictive Cancer Therapy”. In vivo window chamber work was funded in part by Moffitt Cancer Center PS-OC NIH/NCI U54CA143970. This publication was based on work supported in part by Award No. KUK-C1-1013-04, made by King Abdullah University of Science and Technology (KAUST).

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • H. Perfahl
    • 1
    Email author
  • H. M. Byrne
    • 2
  • T. Chen
    • 3
  • V. Estrella
    • 3
  • T. Alarcón
    • 4
  • A. Lapin
    • 1
  • R. A. Gatenby
    • 3
  • R. J. Gillies
    • 3
  • M. C. Lloyd
    • 3
  • P. K. Maini
    • 5
  • M. Reuss
    • 1
  • M. R. Owen
    • 6
  1. 1.Center for Systems-BiologyUniversity of StuttgartStuttgartGermany
  2. 2.Oxford Centre for Collaborative Applied Mathematics, Department of Computer ScienceUniversity of OxfordOxfordUK
  3. 3.H. Lee Moffitt Cancer Center & Research InstituteTampaUSA
  4. 4.Centre de Recerca MatemàticaBarcelonaSpain
  5. 5.Centre for Mathematical Biology, Mathematical Institute and Oxford Centre for Integrative Systems Biology, Department of BiochemistryUniversity of OxfordOxfordUK
  6. 6.Centre for Mathematical Medicine and Biology, School of Mathematical SciencesUniversity of NottinghamNottinghamUK

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