Cytokine–Cytokine Cross Talk and Cell-Death Decisions
Cells often face life or death decisions in response to conflicting extracellular cytokine cues. A full understanding of how this information is encoded has implications for normal development and function of organ systems and also for pathologies where cues are not processed properly. In this chapter, we discuss how life–death decisions are influenced by signaling from pro-survival receptor tyrosine kinases (RTKs) and pro-death tumor necrosis factor (TNF)-family receptors. Intracellular cross talk between these antagonistic receptors is incredibly complex, and our understanding could be improved by systems biology thinking and approaches. We describe key systems-level features of RTK and TNF-family receptor signaling and how points of cross talk may mediate the decision to live or die.
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