Chapter

Nanoplasmonic Sensors

Part of the series Integrated Analytical Systems pp 83-104

Date:

Dual Functions of Nanoplasmonic Optical Antennas: Nanoplasmonic Gene Switches and Biosensors

  • Somin Eunice LeeAffiliated withDepartment of Bioengineering, University of California-Berkeley, UCSF/UCB Joint Graduate Group in Bioengineering, Berkeley Sensor & Actuator Center
  • , Younggeun ParkAffiliated withDepartment of Bioengineering, University of California-Berkeley, UCSF/UCB Joint Graduate Group in Bioengineering, Berkeley Sensor & Actuator CenterDepartment of Chemical and Biomolecular Engineering, Sogang University
  • , Taewook KangAffiliated withDepartment of Chemical and Biomolecular Engineering, Sogang University
  • , Luke P. LeeAffiliated withDepartment of Bioengineering, University of California-Berkeley, UCSF/UCB Joint Graduate Group in Bioengineering, Berkeley Sensor & Actuator Center Email author 

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Abstract

Within a living cell, the intracellular distribution is spatially nonuniform and dynamically changing over time in response to environmental cues. By focusing on electromagnetic fields down to dimensions smaller than the diffraction limit, nanoplasmonic optical antennas, functioning as nanoplasmonic gene switches, enable on- demand and spatially precise regulation of genetic activity to give rise to location-specific function. In addition to on-demand gene regulation, nanoplasmonic optical antennas also function as label-free biosensors that significantly enhance spectral information for plasmon resonance energy transfer, surface-enhanced Raman spectroscopy, and nanoplasmonic molecular rulers. “Spectral snapshots” (i.e., spectroscopic imaging) of the dynamically changing intracellular biochemical distribution can be obtained over time.