Nephroblastoma

  • Jean-Jacques Atteby Yao
  • Norbert Graf
  • Gordan M. Vujanic
Chapter
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Abstract

Nephroblastoma is one of the most common solid childhood cancers which is relatively easy to diagnose and highly curable. The cure rate in developed countries is between 85 and 90 % for all stages together but the survival rate is much lower in developing countries due to multiple factors. There are two main international protocols used in the treatment of the disease: SIOP (International Society of Pediatric Oncology) in Europe, which uses preoperative chemotherapy followed by surgery and further chemotherapy (if necessary), and COG (Children’s Oncology Group, former NWTS—National Wilms Tumor Study group) in North America, which proposes primary surgery, followed by postoperative chemotherapy (and radiotherapy in some stages). The diagnosis of the nephroblastoma is based on a good clinical examination with minimal laboratory and imaging investigations. Postoperative treatment is primarily based on histology and stage. Chemotherapy administered preoperatively offers the advantage in reducing the volume of the tumor and making it more accessible for surgery (reducing a number of intraoperative rupture), which remains the mainstay of the treatment. Radiotherapy remains reserved for advanced stages of the disease in combination with prolonged chemotherapy.

Keywords

Preoperative Chemotherapy Partial Nephrectomy Contralateral Kidney Tumor Rupture Clear Cell Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Jean-Jacques Atteby Yao
    • 1
  • Norbert Graf
    • 2
  • Gordan M. Vujanic
    • 3
  1. 1.Département of MERE-ENFANT, UFR SM Univresité Cocody/Abidjan RCIAbidjanRepublique de Cote d’Ivoire
  2. 2.Department of Pediatric Oncology and OncologySaarland UniversityHomburgGermany
  3. 3.School of Medicine Cardiff UniversityCardiffUK

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