Glioma pp 53-76

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 746)

Mechanisms of Immune Evasion by Gliomas

  • Cleo E. Rolle
  • Sadhak Sengupta
  • Maciej S. Lesniak


A major contributing factor to glioma development and progression is its ability to evade the immune system. This chapter will explore the mechanisms utilized by glioma to mediate immunosuppression and immune evasion. These include intrinsic mechanisms linked to its location within the brain and interactions between glioma cells and immune cells. Lack of recruitment of naïve effector immune cells perhaps accounts for most of the immune suppression mediated by these tumor cells. This is enhanced by increased recruitment of microglia which resemble immature antigen presenting cells that are unable to support T-cell mediated immunity. Furthermore, secreted factors like TGF-β, COX-2 and IL-10, altered costimulatory molecules and inhibition of STAT-3 all contribute to the recruitment and expansion of regulatory T cells, which further modulate the immunosuppressive environment of glioma. In light of these findings, multiple immunotherapeutic treatment modalities are currently being explored.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  • Cleo E. Rolle
    • 1
  • Sadhak Sengupta
    • 1
  • Maciej S. Lesniak
    • 2
  1. 1.Department of Surgery, Section of NeurosurgeryThe University of Chicago Pritzker School of MedicineChicagoUSA
  2. 2.Section of NeurosurgeryThe University of ChicagoChicagoUSA

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