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Glioma pp 42-52 | Cite as

Basic Concepts in Glioma Immunology

  • Ian F. Parney
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 746)

Abstract

Glioblasotmas are the most common primary central nervous system tumor and typically have a dismal prognosis. Immunotherapy has been a promising experimental treatment. Understanding brain tumor immunobiology is critical to designing glioblasotma immunotherapies. In this chapter, we review aspects of basic immunology and neuro-immunology. The antigenic underpinnings of brain tumor immunotherapy including glioma-associated and glioma-specific antigens are discussed. Finally, the molecular and cellular facets of glioma-mediated immunosuppression are outlined. The role of multiple cell types (glioma cells, glioma-infiltrating monocytes, regulatory T cells and myeloid derived suppressor cells) in mediating local and systemic immunosuppression in glioma patients is evaluated.

Keywords

Glioblastoma Cell Major Histocompatibility Complex Molecule Myeloid Derive Suppressor Cell Glioblastoma Patient Immunotherapeutic Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  • Ian F. Parney
    • 1
  1. 1.Department of Neurologic SurgeryMayo ClinicRochesterUSA

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