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Engineering Quasi-Vivo® in Vitro Organ Models

  • Tommaso Sbrana
  • Arti Ahluwalia
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 745)

Abstract

Cell culture is the workhorse of biologists, toxicologists, tissue engineers and a whole host of research fields in both academia and industry. Having explored individual molecular mechanisms inside cells for decades using traditional cell culture techniques, researchers have only just begun to appreciate that the intricate interconnectivity between cells and cellular networks as well as with the external environment is far more important to cellular orchestration than are single molecular events inside the cell. For example many questions regarding cell, tissue, organ and system response to drugs, environmental toxins, stress and nutrients cannot possibly be answered by concentrating on the minutiae of what goes on in the deepest recesses of single cells. New models are required to investigate cellular cross-talk between different cell types and to construct complex in-vitro models to properly study tissue, organ and system interaction without resorting to animal experiments. This chapter describes how tissue and organ models can be developed using the Quasi-Vivo® system and discusses how they may be used in drug toxicity studies.

Keywords

Wall Shear Stress Human Hepatocyte Organ Model Allometric Scaling Allometric Exponent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  1. 1.Centro Interdipartimentale di Ricerca “E. Piaggio,”University of PisaPisaItaly
  2. 2.Kirkstall Ltd.The Sheffield BioIncubatorSheffieldUK

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