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Computational Modeling of Biological Systems

Part of the series Biological and Medical Physics, Biomedical Engineering pp 167-189

Date:

Multiscale Modeling of Virus Structure, Assembly, and Dynamics

  • Eric R. MayAffiliated withDepartment of Chemistry and Biophysics Program, University of Michigan
  • , Karunesh AroraAffiliated withDepartment of Chemistry and Biophysics Program, University of Michigan
  • , Ranjan V. MannigeAffiliated withDepartment of Chemistry and Chemical Biology, Harvard University
  • , Hung D. NguyenAffiliated withDepartment of Chemical Engineering and Materials Science, University of California, Irving
  • , Charles L. BrooksIIIAffiliated withDepartment of Chemistry and Biophysics Program, University of Michigan Email author 

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Abstract

Viruses are traditionally considered as infectious agents that attack cells and cause illnesses like AIDS, Influenza, Hepatitis, etc. However, recent advances have illustrated the potential for viruses to play positive roles for human health, instead of causing disease [1, 2]. For example, viruses can be employed for a variety of biomedical and biotechnological applications, including gene therapy[3], drug delivery[4], tumor targeting[5], and medical imaging[6]. Therefore, it is important to understand quantitatively how viruses operate such that they can be engineered in a predictive manner for beneficial roles.