Abstract
Ion channels represent a class of membrane spanning protein pores that mediate the flux of ions in a variety of cell types. They reside virtually in all the cell membranes in mammals, insects and fungi, and are essential for life, serving as key components in inter- and intracellular communication.1 They are also of major importance for the human physiology and, thus, are highly attractive molecular drug targets.2 However, investigation of ion channels and their pharmacological modulation is by no means an easy task, as their function relies on a laterally mobile and highly insulating lipid bilayer. Functionality of an ion channel is synonymous with the detection of ion currents.
Keywords
- Lipid Bilayer
- Equivalent Circuit
- Electrochemical Impedance Spectroscopy
- Impedance Spectrum
- Conductance State
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2012 Springer Science+Business Media, LLC
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Schmitt, E.K., Steinem, C. (2012). 5 Electrochemical Analysis of Ion Channels and Transporters in Pore-Suspending Membranes. In: Eliaz, N. (eds) Applications of Electrochemistry and Nanotechnology in Biology and Medicine II. Modern Aspects of Electrochemistry, vol 53. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-2137-5_5
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DOI: https://doi.org/10.1007/978-1-4614-2137-5_5
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Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4614-2137-5
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