Chapter

Neural Metabolism In Vivo

Volume 4 of the series Advances in Neurobiology pp 1095-1116

Date:

In Vivo GABA Metabolism

  • In-Young ChoiAffiliated withDepartment of Neurology, Department of Molecular & Integrative Physiology, Hoglund Brain Imaging Center, University of Kansas Medical Center Email author 
  • , Jun ShenAffiliated withSection on Magnetic Resonance Spectroscopy, National Institute of Mental Health, National Institutes of Health, Molecular Imaging Branch , Mood & Anxiety Disorders Program

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Abstract

γ-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain. In the central nervous system (CNS), significant concentration variations and gradients of GABA exist accompanied by its highly active metabolism and transport. To provide an understanding of GABA metabolism in vivo, this chapter covers the pathways of GABA metabolism, as well as methods for measuring GABA and GABAergic neurotransmission in vivo. GABA metabolism is compartmentalized and GABA ­turnover, its release from presynaptic terminals and reuptake into cellular cytoplasm, is linked to glucose and amino acid metabolism. GABAergic dysfunction involving GABA metabolism and/or neurotransmission has been ­implicated in several neurological and psychiatric disorders including epilepsy, depression and schizophrenia.

Keywords

Degradation Epilepsy Metabolism Neurotransmitter NMR spectroscopy Synthesis Turnover γ-aminobutyric acid (GABA)