Self and Nonself pp 277-289

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 738)

The Emergence of the Major Histocompatilibility Complex


The Major Histocompatibility Complex (MHC) is a genomic region that contains genes that encode proteins involved with antigen presentation and, therefore, plays an important role in the adaptive immune system. The origin of these genes was probably an ancestral MHC that appeared before the emergence of the adaptive immune system and contained genes related to immunity. The organization of MHC genes varies in different groups of vertebrates; although, there are some characteristics that are maintained in all groups, which indicates that they confer some evolutionary advantage: Organization of the genes to form clusters and genetic polymorphisms. The study of how the MHC appeared during evolution and how it is organized in different species can help us clarify what features are essential in their participation in self-nonself recognition.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  1. 1.Immunology DepartmentHospital Universitario Central de AsturiasOviedoSpain
  2. 2.Fundación Renal „Iñigo Álvarez de Toledo“MadridSpain

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