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Pharmacologic Interventions to Improve Splanchnic Oxygenation During Ventilation with Positive End-Expiratory Pressure

  • A. FournellEmail author
  • T. W. L. Scheeren
  • O. Picker
  • L. A. Schwarte
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (volume 737)

Abstract

Mechanical ventilation with positive end-expiratory pressure (PEEP) is an indispensable tool in the management of respiratory failure to preserve or improve lung function and systemic oxygenation. However, PEEP per se may also, as has been shown in experimental animals, impair regional microcirculation and oxygenation. The latter effects have received attention of late because of possible systemic sequelae such as multiple system organ failure (MSOF) in case of the splanchnic region. In this review, we examine the impact of pharmacologic interventions to improve splanchnic mucosal oxygen saturation depressed by mechanical ventilation with PEEP in a canine model of compromised cardiac function. Although much remains to be elucidated about the mechanisms of action, the primary way to improve splanchnic oxygenation seems to be a vasodilatory action of the drugs.

Keywords

Continuous Positive Airway Pressure Mean Arterial Pressure Adult Respiratory Distress Syndrome Thoracic Epidural Anesthesia Selective Blockade 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The above-mentioned studies have been funded by a grant from the Research Commission, Medical Faculty, Heinrich-Heine-University Düsseldorf and departmental funds.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • A. Fournell
    • 1
    Email author
  • T. W. L. Scheeren
    • 2
  • O. Picker
    • 1
  • L. A. Schwarte
    • 3
  1. 1.Department of AnesthesiologyHeinrich Heine University DüsseldorfDüsseldorfGermany
  2. 2.Department of AnesthesiologyUniversity Medical Center GroningenGroningenThe Netherlands
  3. 3.Department of AnesthesiologyVU University Medical CenterAmsterdamThe Netherlands

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