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Bio-Macromolecules and Hydration Water Dynamics

  • Kathleen WoodEmail author
  • Martin Weik
Chapter
Part of the Neutron Scattering Applications and Techniques book series (NEUSCATT)

Abstract

Biological macromolecules are dynamic entities, a characteristic which is essential for them to carry out their functions. The vast majority of biological processes are mediated by water and the extent to which macromolecules are hydrated and the solvent type modulate their dynamics. The microscopic properties of the hydration water and how they influence the dynamical behaviour of membranes, proteins, DNA, and RNA are therefore questions of fundamental importance to understand how biological processes occur in cellulo. Here we review neutron-scattering studies on the solvent influence on protein dynamics, studies of hydration water itself, and the first work on characterising cytoplasmic water. Whilst the time- and length-scales accessible by neutrons and their scattering cross-sections make them particularly suitable to the study of water, molecular dynamics simulations are also increasingly used to interpret measurements. Where appropriate, we also cite their results.

Keywords

Molecular Dynamic Simulation Neutron Scattering Hydration Water Translational Diffusion Purple Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Biophysical ChemistryUniversity of GroningenGroningenThe Netherlands
  2. 2.Bragg InstituteAustralian Nuclear Science and Technology OrganisationMenaiAustralia
  3. 3.Institut de Biologie StructuraleGrenobleFrance

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