The Role of Tumour-Associated Macrophages in Malignant Invasion

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Abstract

Influencing cancer cell invasion is one of the many ways, tumor-associated macrophages (TAM) can foster tumor progression. Penetration of the basement membrane and movement of tumor cells through tissues usually require enhanced motile capacity as well as reorganization of the invaded structures via pericellular proteolysis. Malignant cells secrete chemo- and cytokines to attract macrophages, which are then polarized into the TAM-phenotype and, in turn, produce a huge arsenal of factors with pro-invasive activity. Among these factors are members of several pro-migratory signaling cascades, such as the EGF/CSF-1 loop, TNFα, the CXCR4/CXCL12 axis as well as other chemokines and their receptors. Para- as well as autocrine activation of these pathways directly stimulates tumor cell motility and, additionally, induces tissue remodeling by the upregulation of proteases. Thus, TAM are key actors at the tumor–host boundary, influencing invasion directly by the activation of migration-associated signaling as well as indirectly through supply of critical downstream effectors.

Keywords

Epidermal Growth Factor Receptor Epidermal Growth Factor Receptor Signaling Tumour Cell Motility Malignant Invasion Cellular Protrusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Hematology/OncologyUniversity of GöttingenGöttingenGermany

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