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Kuru: The First Prion Disease

  • Paweł P. LiberskiEmail author
  • Beata Sikorska
  • Paul Brown
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 724)

Abstract

Kuru disease is linked with the name of D. Carleton Gajdusek and he was the first to show that this human neurodegenerative disease can be transmitted to chimpanzees and subsequently classified as a transmissible spongiform encephalopathy (TSE), or slow unconventional virus disease. It was first reported to Western world in 1957 by Gajdusek and Vincent Zigas,1,2 and in 1975 a complete bibliography of kuru was published by Alpers et al.3 “Kuru” in the Fore language in Papua New Guinea means to shiver from fever and cold. The disease has been found to spread through ritualistic cannibalism and is an invariably fatal cerebellar ataxia accompanied by tremor, choreiform and athetoid movements. Neuropathologically, kuru is characterized by the presence of amyloid “kuru” plaques.

Keywords

Neurodegenerative Disease Prion Disease Cerebellar Ataxia Transmissible Spongiform Encephalopathy Intracellular Vacuole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2012

Authors and Affiliations

  • Paweł P. Liberski
    • 1
    Email author
  • Beata Sikorska
    • 1
  • Paul Brown
    • 2
  1. 1.Laboratory of Electron Microscopy and Neuropathology, Department of Molecular Pathology and NeuropathologyMedical University LodzLodzPoland
  2. 2.CEA/DSV/iMETI/SEPIAFontenay-aux-RosesFrance

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