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A Tale of Two Kinases in Rods and Cones

  • Shoji Osawa
  • Ellen R. WeissEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 723)

Abstract

Members of the G protein-coupled receptor kinase family play essential roles in signal turnoff for the majority of G protein-coupled receptors. GRK1, first identified almost 40 years ago, and GRK7, the most recently identified member of the GRK family, are retina-specific GRKs involved in the recovery and adaptation of rod and cone photoreceptors in the vertebrate retina. This report reviews the expression patterns of these two kinases, as well as the effect of their interaction with their substrates and binding partners. The phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase (PKA) is also discussed.

Keywords

GRK Rod Kinase Cone Photoreceptor PKA Recoverin Opsin Rhodopsin cAMP 

Notes

Acknowledgments

The authors would like to acknowledge financial support from the NEI (EY072224 and EY019758) and from the NIH Core Grant for Vision Research (EY5722; Duke University).

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Cell and Developmental BiologyThe University of North Carolina at Chapel HillChapel HillUSA
  2. 2.Lineberger Comprehensive Cancer CenterThe University of North Carolina at Chapel HillChapel HillUSA

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