A Tale of Two Kinases in Rods and Cones
Members of the G protein-coupled receptor kinase family play essential roles in signal turnoff for the majority of G protein-coupled receptors. GRK1, first identified almost 40 years ago, and GRK7, the most recently identified member of the GRK family, are retina-specific GRKs involved in the recovery and adaptation of rod and cone photoreceptors in the vertebrate retina. This report reviews the expression patterns of these two kinases, as well as the effect of their interaction with their substrates and binding partners. The phosphorylation of GRK1 and GRK7 by cAMP-dependent protein kinase (PKA) is also discussed.
KeywordsGRK Rod Kinase Cone Photoreceptor PKA Recoverin Opsin Rhodopsin cAMP
The authors would like to acknowledge financial support from the NEI (EY072224 and EY019758) and from the NIH Core Grant for Vision Research (EY5722; Duke University).
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