A Window to Innate Neuroimmunity: Toll-Like Receptor-Mediated Cell Responses in the Retina
The retina and its supporting cellular architecture are a valuable biologic system to study neurocytotoxic responses that may reveal important pathways in both retinal and neural degenerative diseases. The innate immune pathway mediated by toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA. TLR3 is found both on the cell surface and in endosomes of multiple retinal cell types. Here, we briefly review critical TLR3 signaling pathways and explore the role of receptor activation in neuroimmunity, age-related macular degeneration, and RNA-based drugs.
KeywordsMacular degeneration Innate immunity Toll-like receptor Apoptosis Double-stranded RNA Short interfering RNA Angiogenesis Choroidal neovascularization Caspase
- Berge M, Bonnin P, Sulpice E et al (2010) Small Interfering RNAs Induce Target-Independent Inhibition of Tumor Growth and Vasculature Remodeling in a Mouse Model of Hepatocellular Carcinoma. Am J PatholGoogle Scholar
- Klein ML, Ferris FL, 3 rd, Francis PJ et al (2010) Progression of geographic atrophy and genotype in age-related macular degeneration. Ophthalmology 117:1554–1559, 1559 e1551Google Scholar