Fine Particles in Medicine and Pharmacy pp 147-173 | Cite as
Biomedical Applications of Magnetic Particles
Abstract
Magnetic particles of nano- and micro-size functionalized with various biomolecules were synthesized and extensively used for many bioanalytical and biomedical applications. Different biosensors, including immunosensors and DNA sensors, were developed using functionalized magnetic particles for their operation in vitro and in vivo. Their use for magnetic targeting (drugs, genes, radiopharmaceuticals), magnetic resonance imaging, diagnostics, immunoassays, RNA and DNA purification, gene cloning, cell separation and purification has been developed. The present chapter summarizes the recent advances in the bioanalytical and biomedical applications of functional magnetic particles.
Keywords
Magnetic particles Nanoparticels Magnetism Biomedical applications Nanotechnology NanobiotechnologyReferences
- 1.Scientific and Clinical Applications of Magnetic Carriers, U. Häfeli, W. Schütt, J. Teller, M. Zborowski (Eds.), Plenum Press, New York, 1997.Google Scholar
- 2.Z. Liu, D. Zhang, S. Han, C. Li, B. Lei, W. Lu, J. Fang, C. Zhou, J. Am. Chem. Soc. 2005, 127, 6-7.Google Scholar
- 3.F.-H. Wang, T. Yoshitake, D.-K. Kim, M. Muhammed, B. Bjelke, Jan Kehr, J. Nanoparticle Res. 2003, 5, 137-146.Google Scholar
- 4.S. Bucak, D.A. Jones, P.E. Laibinis, T.A. Hatton, Biotechnol. Prog. 2003, 19, 477-484.Google Scholar
- 5.L. Stanciu, Y.H. Won, M. Ganesana, S. Andreescu, Sensors 2009, 9, 2976-2999.Google Scholar
- 6.S. Andreescu, J. Njagi, C. Ispas, M.T. Ravalli, J. Environmental Monitoring 2009, 11, 27-40.Google Scholar
- 7.S. Yu, G.M. Chow, J. Mater. Chem. 2004, 14, 2781-2786.Google Scholar
- 8.X. Liu, J. Xing, Y. Guan, G. Shan, H. Liu, Colloids Surfaces A 2004, 238, 127-131.Google Scholar
- 9.N.R. Jana, Y. Chen, X. Peng, Chem. Mater. 2004, 16, 3931-3935.Google Scholar
- 10.J. Lai, K.V.P.M. Shafi, A. Ulman, K. Loos, Y. Lee, T. Vogt, W.-L. Lee, N.P. Ong, J. Phys. Chem. B 2005, 109, 15-18.Google Scholar
- 11.D.L. Huber, Small 2005, 1, 482-501.Google Scholar
- 12.P. Tartaj, M.P. Morales, T. González-Carreño, S. Veintemillas-Verdaguer, C.J. Serna, J. Magnet. Magnet. Mater. 2005, 290-291, 28-34.Google Scholar
- 13.L. Shen, P. E. Laibinis, T.A. Hatton, Langmuir 1999, 15, 447-453.Google Scholar
- 14.T. Hyeon, Chem. Commun. 2003, 927-934.Google Scholar
- 15.A.K. Gupta, M. Gupta, Biomaterials 2005, 26, 3995-4021.Google Scholar
- 16.S. Sun, H. Zeng, J. Am. Chem. Soc. 2002, 124, 8204-8205.Google Scholar
- 17.L.P. Silva, Z.G.M. Lacava, N. Buske, P.C. Morais R.B. Azevedo, J. Nanoparticle Res. 2004, 6, 209-213.Google Scholar
- 18.E. Matijević, Langmuir 1994, 10, 8-16.Google Scholar
- 19.K.G. Paul, T.B. Frigo, J.Y. Groman, E.V. Groman, Bioconjugate Chem. 2004, 15, 394-401.Google Scholar
- 20.L.F. Gamarra, G.E.S. Brito, W.M. Pontuschka, E. Amaro, A.H.C. Parma, G.F. Goya, J. Magnet.Magnet. Mater. 2005, 289, 439-441.Google Scholar
- 21.J. Park, E. Lee, N.-M. Hwang, M. Kang, S.C. Kim, Y. Hwang, J.-G. Park, H.-J. Noh, J.-Y. Kim, J.-H. Park, T. Hyeon, Angew. Chem. Int. Ed. 2005, 44, 2872-2877.Google Scholar
- 22.G. Li, J. Fan, R. Jiang, Y. Gao, Chem. Mater. 2004, 16, 1835-1837.Google Scholar
- 23.H. Zeng, S. Sun, J. Li, Z.L. Wang, J.P. Liu, Appl. Phys. Lett. 2004, 85, 792-794.Google Scholar
- 24.A. Hütten, D. Sudfeld, I. Ennen, G. Reiss, K. Wojczykowski, P. Jutzi, J. Magnet. Magnet. Mater. 2005, 293, 93-101.Google Scholar
- 25.R. Mikami, M. Taguchi, K. Yamada, K. Suzuki, O. Sato, Y. Einaga, Angew. Chem. Int. Ed. 2004, 43, 6135-6139.Google Scholar
- 26.V.K. Sharma, F. Waldner, J. Appl. Phys. 1977, 48, 4298-4302.Google Scholar
- 27.J. Baker-Jarvis, P. Kabos, Phys. Rev. E 2001, 64, 056127-1-056127-14.Google Scholar
- 28.S. Mørup, E. Tronc, Phys. Rev. Lett. 1994, 72, 3278-3281.Google Scholar
- 29.M. Mandal, S. Kundu, S.K. Ghosh, S. Panigrahi, T.K. Sau, S.M. Yusuf, T. Pal, J. Colloid Interface Sci. 2005, 286, 187-194.Google Scholar
- 30.M. Chen, S. Yamamuro, D. Farrell, S.A. Majetich, J. Appl. Phys. 2003, 93, 7551-7553.Google Scholar
- 31.Y. Bao, K.M. Krishnan, J. Magnet. Magnet. Mater. 2005, 293, 15-19.Google Scholar
- 32.Y. Cui, Y. Wang, W. Hui, Z. Zhang, X. Xin, C. Chen, Biomed. Microdevices 2005, 7, 153-156.Google Scholar
- 33.L. Wang, J. Luo, M.M. Maye, Q. Fan, Q. Rendeng, M.H. Engelhard, C. Wang, Y. Lin, C.-J. Zhong, J. Mater. Chem. 2005, 15, 1821-1832.Google Scholar
- 34.X. Gao, K.M.K. Yu, K.Y. Tam, S.C. Tsang, Chem. Commun. 2003, 2998-2999.Google Scholar
- 35.H.-H. Yang, S.-Q. Zhang, X.-L. Chen, Z.-X. Zhuang, J.-G. Xu, X.-R. Wang, Anal. Chem. 2004, 76, 1316-1321.Google Scholar
- 36.W. Zhao, J. Gu, L. Zhang, H. Chen, J. Shi, J. Am. Chem. Soc. 2005, 127, 8916-8917.Google Scholar
- 37.S.H. Yun, C.W. Lee, J.S. Lee, C.W. Seo, E.K. Lee, Mater. Sci. Forum 2004, 449, 1033-1036.Google Scholar
- 38.Y.P. He, S.Q. Wang, C.R. Li,Y.M. Miao, Z.Y. Wu, B.S. Zou, J. Phys. D 2005, 38, 1342-1350.Google Scholar
- 39.S.J. Son, J. Reichel, B. He, M. Schuchman, S.B. Lee, J. Am. Chem. Soc. 2005, 127, 7316-7317.Google Scholar
- 40.H. Lu, G. Yi, S. Zhao, D. Chen, L.-H. Guo, J. Cheng, J. Mater. Chem. 2004, 14, 1336-1341.Google Scholar
- 41.X. Hong, J. Li, M. Wang, J. Xu, W. Guo, J. Li, Y. Bai, T. Li, Chem.Mater. 2004, 16, 4022-4027.Google Scholar
- 42.H. Kim, M. Achermann, L.P. Balet, J.A. Hollingsworth, V.I. Klimov, J. Am. Chem. Soc. 2005, 127, 544-546.Google Scholar
- 43.H. Gu, Z. Yang, J. Gao, C.K. Chang, B. Xu, J. Am. Chem. Soc. 2005, 127, 34-35.Google Scholar
- 44.H. Gu, R. Zheng, X.-X. Zhang, B. Xu, J. Am. Chem. Soc. 2004, 126, 5664-5665.Google Scholar
- 45.H. Yu, M. Chen, P.M. Rice, S.X. Wang, R.L. White, S. Sun, Nano Lett. 2005, 5, 379-382.Google Scholar
- 46.D.K. Yi, S.T. Selvan, S.S. Lee, G.C. Papaefthymiou, D. Kundaliya, J.Y. Ying, J. Am. Chem. Soc. 2005, 127, 4990-4991.Google Scholar
- 47.P.C. Morais, J.G. Santos, L.B. Silveira, C. Gansau, N. Buske, W.C. Nunes, J.P. Sinnecker, J. Magnet.Magnet. Materials 2004, 272-276, 2328-2329.Google Scholar
- 48.A. del Campo, T. Sen, J.-P. Lellouche, I.J. Bruce, J. Magnet.Magnet. Mater. 2005, 293, 33-40.Google Scholar
- 49.I.J. Bruce, T. Sen, Langmuir 2005, 21, 7029-7035.Google Scholar
- 50.T. Tanaka, T. Matsunaga, Anal. Chem. 2000, 72, 3518-3522.Google Scholar
- 51.C.R. Martin, D.T. Mitchell, Anal.Chem. 1998, 70, 322A-327A.Google Scholar
- 52.M. Fuentes, C. Mateo, J.M. Guisán, R. Fernández-Lafuente, Biosens. Bioelectron. 2005, 20, 1380-1387.Google Scholar
- 53.F. Gao, B.-F. Pan, W.-M. Zheng, L.-M. Ao, H.-C. Gu, J. Magnet. Magnet. Mater. 2005, 293, 48-54.Google Scholar
- 54.C. Xu, K. Xu, H. Gu, R. Zheng, H. Liu, X. Zhang, Z. Guo, B. Xu, J. Am. Chem. Soc. 2004, 126, 9938-9939.Google Scholar
- 55.Z.G. Peng, K. Hidajat, M.S. Uddin, J. Colloid Interface Sci. 2004, 271, 277-283.Google Scholar
- 56.M. Mikhaylova, D.K. Kim, C.C. Berry, A. Zagorodni, M. Toprak, A.S.G. Curtis, M. Muhammed, Chem. Mater. 2004, 16, 2344-2354.Google Scholar
- 57.A. Dyal, K. Loos, M. Noto, S.W. Chang, C. Spagnoli, K.V.P.M. Shafi, A. Ulman, M. Cowman, R.A. Gross, J. Am. Chem. Soc. 2003, 125, 1684-1685.Google Scholar
- 58.M. Ma, Y. Zhang, W. Yu, H. Shen, H. Zhang, N. Gu, Colloids Surfaces A 2003, 212, 219-226.Google Scholar
- 59.S.-H. Huang, M.-H. Liao, D.-H. Chen, Biotechnol. Prog. 2003, 19, 1095-1100.Google Scholar
- 60.D. Cao, P. He, N. Hu, Analyst 2003, 128, 1268-1274.Google Scholar
- 61.M. Shinkai, H. Honda, T. Kobayashi, Biocatalysis 1991, 5, 61-69.Google Scholar
- 62.M.-H. Liao, D.-H. Chen, Biotechnol.Lett. 2001, 23, 1723-1727.Google Scholar
- 63.M.-H. Liao, D.-H. Chen, Biotechnol. Lett. 2002, 24, 1913-1917.Google Scholar
- 64.X.-L. Sun, W. Cui, C. Haller, E.L. Chaikof, ChemBioChem 2004, 5, 1593-1596.Google Scholar
- 65.S. Mornet, A. Vekris, J. Bonnet, E. Duguet, F. Grasset, J.-H. Choy, J. Portier, Mater. Lett. 2000, 42, 183-188.Google Scholar
- 66.L.E. Euliss, S.G. Grancharov, S. O’Brien, T.J. Deming, G.D. Stucky, C.B. Murray, G.A. Held, Nano Lett. 2003, 3, 1489-1493.Google Scholar
- 67.D. Horák, B. Rittich, A. Španová, M.J. Benes, Polymer 2005, 46, 1245-1255.Google Scholar
- 68.X. Liu, Y. Guan, Y. Yang, Z. Ma, X. Wu, H. Liu, J. Appl. Polymer Sci. 2004, 94, 2205-2211.Google Scholar
- 69.A.-N. Kawde, M.C. Rodriguez, T.M.H. Lee, J. Wang, Electrochem.Commun. 2005, 7, 537-540.Google Scholar
- 70.H. Xu, H. Wu, F. Huang, S. Song, W. Li, Y. Cao, C. Fan, Nucleic Acids Res. 2005, 33, paper e83.Google Scholar
- 71.K.-B. Lee, S. Park, C.A. Mirkin, Angew. Chem. Int. Ed. 2004, 43, 3048-3050.Google Scholar
- 72.C.R. Martin, Science 1994, 266, 1961-1966.Google Scholar
- 73.D. Routkevitch, T. Bigioni, M. Moskovits, J.M. Xu, J. Phys. Chem. 1996, 100, 14037-14047.Google Scholar
- 74.D.H. Reich, M. Tanase, A. Hultgren, L.A. Bauer, C.S. Chen, G.J. Meyer, J. Appl.Phys. 2003, 93, 7275-7280.Google Scholar
- 75.G. Amagliani, G. Brandi, E. Omiccioli, A. Casiere, I.J. Bruce, M. Magnani, Food Microbiol. 2004, 21, 597-603.Google Scholar
- 76.S.V. Sonti, A. Bose, J. Colloid Inter. Sci. 1995, 170, 575-585.Google Scholar
- 77.J. Roger, J.N. Pons, R. Massart, A. Halbreich, J.C. Bacri, Eur. Phys. J. Appl. 1999, 5, 321-325.Google Scholar
- 78.X.-L. Su, Y. Li, Anal. Chem. 2004, 76, 4806-4810.Google Scholar
- 79.K.-C. Ho, P.-J. Tsai, Y.-S. Lin, Y.-C. Chen, Anal. Chem. 2004, 76, 7162-7168.Google Scholar
- 80.H. Gu, P.-L. Ho, K.W.T. Tsang, C.-W. Yu. B. Xu, Chem. Commun. 2003, 1966-1967.Google Scholar
- 81.H. Gu, P.-L. Ho, K.W.T. Tsang, L. Wang, B. Xu, J. Am. Chem. Soc. 2003, 125, 15702-15703.Google Scholar
- 82.M. Kuhara, H. Takeyama, T. Tanaka, T. Matsunaga, Anal.Chem. 2004, 76, 6207-6213.Google Scholar
- 83.G.A. Prinz, Science 1998, 282, 1660-1663.Google Scholar
- 84.D.L. Graham1, H.A. Ferreira, P.P. Freitas, Trends Biotechnol. 2004, 22, 455-462.Google Scholar
- 85.J. Richardson, A. Hill, R. Luxton, P. Hawkins, Biosens. Bioelectron. 2001, 16, 1127-1132.Google Scholar
- 86.J. Richardson, P. Hawkins, R. Luxton, Biosens. Bioelectron. 2001, 16, 989-993.Google Scholar
- 87.S.G. Grancharov, H. Zeng, S. Sun, S.X. Wang, S.O’Brien, C.B. Murray, J.R. Kirtley, G.A. Held, J. Phys. Chem. B 2005, 109, 13030-13035.Google Scholar
- 88.S.-K. Lee, W.R. Myers, H.L. Grossman, H.-M. Cho, Y.R. Chemla, J. Clarke, Appl. Phys. Lett. 2002, 81, 3094-3096.Google Scholar
- 89.S. Katsura, T. Yasuda, K. Hirano, A. Mizuno, S. Tanaka, Supercond. Sci. Technol. 2001, 14, 1131-1134.Google Scholar
- 90.K. Enpuku, A. Ohba, K. Inoue, T.Q. Yang, Physica C 2004, 412-414, 1473-1479.Google Scholar
- 91.D. Abrahamsson, K. Kriz, M. Lub, D. Kriz, Biosens. Bioelectron. 2004, 19, 1549-1557.Google Scholar
- 92.W. Thomson, Proc. R. Soc. London A 1857, 8, 546-550.Google Scholar
- 93.M.M. Miller, G.A. Prinz, S.-F. Cheng, S. Bounnak, Appl. Phys. Lett. 2002, 81, 2211-2213.Google Scholar
- 94.R.L. Edelstein, C.R. Tamanaha, P.E. Sheehan, M.M. Miller, D.R. Baselt, L.J. Whitman, R.J. Colton, Biosens. Bioelectron. 2000, 14, 805-813.Google Scholar
- 95.M.M. Miller, P.E. Sheehan, R.L. Edelstein, C.R. Tamanaha, L. Zhong, S. Bounnak, L.J. Whitman, R.J. Colton, J. Magnet. Magnet. Mater. 2001, 225, 138-144.Google Scholar
- 96.J.C. Rife, M.M. Miller, P.E. Sheehan, C.R. Tamanaha, M. Tondra, L.J. Whitman, Sens. Actuat. A 2003, 107, 209-218.Google Scholar
- 97.L. Lagae, R. Wirix-Speetjens, J. Das, D. Graham, H. Ferreira, P.P.F. Freitas, G. Borghs, J. De Boeck, J. Appl. Phys. 2002, 91, 7445-7447.Google Scholar
- 98.D.L. Graham, H. Ferreira, J. Bernardo, P.P. Freitas, J.M.S. Cabral, J. Appl. Phys. 2002, 91, 7786-7788.Google Scholar
- 99.H.A. Ferreira, D.L. Graham, P.P. Freitas, J.M.S. Cabral, J. Appl. Phys. 2003, 93, 7281-7286.Google Scholar
- 100.G. Li, V. Joshi, R.L. White, S.X. Wang, J.T. Kemp, C. Webb, R.W. Davis, S. Sun, J. Appl. Phys. 2003, 93, 7557-7559.Google Scholar
- 101.D.R. Baselt, G.U. Lee, M. Natesan, S.W. Metzger, P.E. Sheehan, R.J. Colton, Biosens. Bioelectron. 1998, 13, 731-739.Google Scholar
- 102.D.L. Graham, H.A. Ferreira, P.P. Freitas, J.M.S. Cabral, Biosens. Bioelectron. 2003, 18, 483-488.Google Scholar
- 103.M. Megens, M. Prins, J. Magnet. Magnet. Mater. 2005, 293, 702-708.Google Scholar
- 104.P.-A. Besse, G. Boero, M. Demierre, V. Pott, R. Popovic, Appl. Phys. Lett. 2002, 80, 4199-4201.Google Scholar
- 105.D.L. Graham, H.A. Ferreira, N. Feliciano, P.P. Freitas, L.A. Clarke, M.D. Amaral, Sens. Actuat. B 2005, 107, 936-944.Google Scholar
- 106.A.P. Astalan, F. Ahrentorp, C. Johansson, K. Larsson, A. Krozer, Biosens. Bioelectron. 2004, 19, 945-951.Google Scholar
- 107.C. Wilhelm, F. Gazeau, J. Roger, J.N. Pons, M.F. Salis, R. Perzynski, J.C. Bacri, Phys. Rev. E 2002, 65, 031404-1-031404-9.Google Scholar
- 108.S.H. Chung, A. Hoffmann, S.D. Bader, C. Liu, B. Kay, L. Makowski, L. Chen, Appl. Phys. Lett. 2004, 85, 2971-2973.Google Scholar
- 109.H.L. Grossman, W.R. Myers, V.J. Vreeland, R. Bruehl, M.D. Alper, C.R. Bertozzi, J. Clarke, Proc. Nat. Acad. Sci. US 2004, 101, 129-134.Google Scholar
- 110.C.J. Behrend, J.N. Anker, B.H. McNaughton, M. Brasuel, M.A. Philbert, R. Kopelman, J. Phys. Chem. B 2004, 108, 10408-10414.Google Scholar
- 111.G. Glöckl, V. Brinkmeier, K. Aurich, E. Romanus, P. Weber, W. Weitschies, J. Magnet. Magnet. Mater. 2005, 289, 480-483.Google Scholar
- 112.J.M. Perez, L. Josephson, R. Weissleder, ChemBioChem 2004, 5, 261-264.Google Scholar
- 113.T. Shen, R. Weissleder, M. Papisov, A. Bogdanov, T.J. Brady, Magnet. Resonance Med. 1993, 29, 599-604.Google Scholar
- 114.P. Gillis, F. Moiny, R.A. Brooks, Magnet. Resonance Med. 2002, 47, 257-263.Google Scholar
- 115.R.A. Brooks, Magnet. Resonance Med. 2002, 47, 388-391.Google Scholar
- 116.J.G. Santos, L.B. Silveira, C. Gansau, N. Buske, P.C. Morais, J. Magn. Magn. Mater. 2004, 272-276, 2330-2331.Google Scholar
- 117.L. Josephson, J.M. Perez, R. Weissleder, Angew. Chem. Int. Ed. 2001, 40, 3204-3206.Google Scholar
- 118.J.M. Perez, L. Josephson, T. O’Loughlin, D. Högelmann, R. Weissleder, Nature Biotechnol. 2002, 20, 816-820.Google Scholar
- 119.P. Wunderbaldinger, L. Josephson, R. Weissleder, Acad. Radiol. 2002, 9, S304-S306.Google Scholar
- 120.D. Högemann, L. Josephson, R. Weissleder, J.P. Basilion, Bioconjugate Chem. 2000, 11, 941-946.Google Scholar
- 121.D. Högemann, V. Ntziachristos, L. Josephson, R. Weissleder, Bioconjugate Chem. 2002, 13, 116-121.Google Scholar
- 122.A. Tsourkas, O. Hofstetter, H. Hofstetter, R. Weissleder, L. Josephson, Angew. Chem. Int. Ed. 2004, 43, 2395-2399.Google Scholar
- 123.J.M. Perez, F.J. Simeone, Y. Saeki, L. Josephson, R. Weissleder, J. Am. Chem. Soc. 2003, 125, 10192-10193.Google Scholar
- 124.H.W. Kang, L. Josephson, A. Petrovsky, R. Weissleder, A. Bogdanov, Jr. Bioconjugate Chem. 2002, 13, 122-127.Google Scholar
- 125.J.M. Perez, F.J. Simeone, A. Tsourkas, L. Josephson, R. Weissleder, Nano Lett. 2004, 4, 119-122.Google Scholar
- 126.M. Zhao, L. Josephson, Y. Tang, R. Weissleder, Angew. Chem. Int. Ed. 2003, 42, 1375-1378.Google Scholar
- 127.J.M. Perez, T. O’Loughin, F.J. Simeone, R. Weissleder, L. Josephson, J. Am. Chem. Soc. 2002, 124, 2856-2857.Google Scholar
- 128.J. Grimm, J.M. Perez, L. Josephson, R. Weissleder, Cancer Res. 2004, 64, 639-643.Google Scholar
- 129.M. Pita, J. M. Abad, C. Vaz-Dominguez, C. Briones, E. Mateo-Martí , J. A. Martín-Gago, M. P. Morales, V. M. Fernández. J. Coll. Interf. Sci. 2008, 321, 484-492.Google Scholar
- 130.J. Jimenez, R. Sheparovych, M. Pita, A. Narvaez Garcia, E. Dominguez, S. Minko, E. Katz, J. Phys. Chem. C 2008, 112, 7337-7344.Google Scholar
- 131.M. Pita, T.K. Tam, S. Minko, E. Katz, ACS Appl. Mater. Interfaces 2009, 1, 1166-1168.Google Scholar