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Nuclear Barrier Hypothesis of Aging as Mechanism for Trade-Off Growth to Survival

  • Sang Chul ParkEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 720)

Abstract

When the aging-dependent cellular behaviors toward growth factors and toxic stress have been analyzed, the perinuclear accumulation of the activated signals, either mitogenic or apoptotic, has been observed, suggesting the aging-dependent inefficiency of the nucleocytoplasmic trafficking of the signals. Thereby, it would be natural to assume the operation of the functional nuclear barrier in aging-dependent manner, which would be designated as “Park and Lim’s Barrier.” And for the ultimate transcriptional factor for these aging-dependent changes of the functional nuclear barrier, Sp1 transcriptional factor has been suggested to be the most probable candidate. This novel mechanism of aging-dependent operation of the functional nuclear barrier is proposed as the ultimate checking mechanism for cellular protection against toxic environment and the general mechanism for the trade-off growth to survival in aging.

Keywords

Senescent Cell Major Vault Protein Epidermal Growth Factor Stimulation Cargo Molecule Growth Factor Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (2010-0029150) and also by the Korea Research Foundation for Health Science.

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologySeoul National University Medical SchoolSeoulSouth Korea
  2. 2.Lee Gil Ya Cancer and Diabetes InstituteGachon University of Medicine and ScienceIncheonSouth Korea

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