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A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects

  • Bruce D. Wines
  • Halina M. Trist
  • William Farrugia
  • Chloe Ngo
  • John Trowsdale
  • Thomas Areschoug
  • Gunnar Lindahl
  • John D. Fraser
  • Paul A. Ramsland
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 946)

Abstract

A common site in the constant region (Fc) of immunoglobulins is recognized by host receptors and is a frequent target of proteins expressed by pathogens. This site is located at the junction of two constant domains in the antibody heavy chains and produces a large shallow cavity formed by loops of the CH2 and CH3 domains in IgG and IgA (CH3 and CH4 domains in IgM). Crystal structures have been determined for complexes of IgG-Fc and IgA-Fc with a structurally diverse set of host, pathogen and in vitro selected ligands. While pathogen proteins may directly block interactions with the immunoglobulins thereby evading host immunity, it is likely that the same pathogen molecules also interact with other host factors to carry out their primary biological function. Herein we review the structural and functional aspects of host and pathogen molecular recognition of the common site on the Fc of immunoglobulins. We also propose that some pathogen proteins may promote virulence by affecting the bridging between innate and adaptive immunity.

Keywords

Pathogen Host Antibody Complement Bacteria Carbohydrate Crystal structure Domain junction 

Notes

Acknowledgments

This work was funded by grant ID543317 (to PAR and BDW) from the National Health and Medical Research Council of Australia (NHMRC). PAR was a recipient of an RD Wright CDA (ID365209) from the NHMRC. JT was supported by the MRC and the Wellcome Trust with partial support from the NIHR Cambridge Biomedical Research Centre. The authors gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program received by the Burnet Institute.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Bruce D. Wines
    • 1
    • 2
    • 3
  • Halina M. Trist
    • 1
  • William Farrugia
    • 1
  • Chloe Ngo
    • 1
    • 2
  • John Trowsdale
    • 4
  • Thomas Areschoug
    • 5
  • Gunnar Lindahl
    • 5
  • John D. Fraser
    • 6
  • Paul A. Ramsland
    • 1
    • 3
    • 7
  1. 1.Centre for ImmunologyBurnet InstituteMelbourneAustralia
  2. 2.Department of PathologyUniversity of MelbourneMelbourneAustralia
  3. 3.Department of ImmunologyMonash UniversityMelbourneAustralia
  4. 4.Department of Pathology, Immunology Division, Cambridge Institute for Medical ResearchUniversity of CambridgeCambridgeUK
  5. 5.Department of Laboratory Medicine, Division of Medical MicrobiologyLund UniversityLundSweden
  6. 6.School of Medical Sciences and Maurice Wilkins Centre of ExcellenceUniversity of AucklandAucklandNew Zealand
  7. 7.Centre for ImmunologyBurnet InstituteMelbourneAustralia

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