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Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution

  • Gerardo R. VastaEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 946)

Abstract

Galectins constitute an evolutionary conserved family of ß-galactoside-binding proteins, ubiquitous in mammals and other vertebrate taxa, invertebrates, and fungi. Since their discovery in the 1970s, their biological roles, initially understood as limited to recognition of carbohydrate ligands in embryogenesis and development, have expanded in recent years by the discovery of their immunoregulatory activities. A gradual paradigm shift has taken place in the past few years through the recognition that galectins also bind glycans on the surface of potentially pathogenic microbes, and function as recognition and effector factors in innate immunity. Further, an additional level of functional complexity has emerged with the most recent findings that some parasites “subvert” the recognition roles of the vector/host galectins for successful attachment or invasion.

Keywords

Pattern recognition receptors Galectins ß-Galactoside Carbohydrate recognition domain Glycans Structure Function Proto-type Chimera Tandem-repeat 

Notes

Acknowledgments

Research in the author’s lab reviewed here was supported by grant 5R01GM070589-06 from the National Institutes of Health, and grants IOB-0618409 and IOS0822257 from the National Science Foundation.

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Microbiology and Immunology, School of Medicine, IMETUniversity of MarylandBaltimoreUSA

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