Pentraxins in Humoral Innate Immunity

  • Antonio Inforzato
  • Barbara Bottazzi
  • Cecilia Garlanda
  • Sonia Valentino
  • Alberto Mantovani
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 946)

Abstract

Innate immunity represents the first line of defence against pathogens and plays key roles in activation and orientation of the adaptive immune response. The innate immune system comprises both a cellular and a humoral arm. Components of the humoral arm include soluble pattern recognition molecules (PRMs) that recognise pathogens associated molecular patterns (PAMPs) and initiate the immune response in coordination with the cellular arm, therefore acting as functional ancestors of antibodies. The long pentraxin PTX3 is a prototypic soluble PRM that is produced at sites of infection and inflammation by both somatic and immune cells. Gene targeting of this evolutionarily conserved protein has revealed a non-redundant role in resistance to selected pathogens. Moreover, PTX3 exerts important functions at the crossroad between innate immunity, inflammation and female fertility. Here we review the studies on PTX3, with emphasis on pathogen recognition and crosstalk with other components of the innate immune system.

Keywords

Pentraxins PTX3 Inflammation Innate immunity Tissue remodeling Biomarkers 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Antonio Inforzato
    • 1
  • Barbara Bottazzi
    • 1
  • Cecilia Garlanda
    • 1
  • Sonia Valentino
    • 1
  • Alberto Mantovani
    • 1
    • 2
  1. 1.Istituto Clinico Humanitas IRCCSRozzanoItaly
  2. 2.Department of Translational MedicineUniversity of MilanRozzanoItaly

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