Augmented Reality for Nano Manipulation
In recent research in nano and micro world, the Atomic Force Microscope (AFM)  plays more and more important role because of high resolution image  and vacuum free working environment. With the help of AFM, it makes people more convenience to get high quality live cell or fixed cell image . The AFM also has the ability to test and measure the mechanical characteristic of sample such as force curve, Young’s modulus and roughness [3, 4], therefore, some researchers [4–6] focus on the subject of measuring the mechanical property of living cell or using functionalized tip to stimulate the cell by means of electric or chemical solution [7–9]. The vacuum free working environment makes AFM much more flexible in various working conditions both in air and liquid.
KeywordsAtomic Force Microscope Visual Feedback Atomic Force Microscope Image Augmented Reality HaCaT Cell
This research work is partially supported under NSF Grants IIS-0713346 and DMI-0500372; ONR Grants N00014-04-1-0799 and N00014-07-1-0935; NIH Grant: R43 GM084520 (Angelo).
The authors would also like to thank Dr. Chanmin Su of Bruker Nano Surface Instrumentation Group (former Veeco Instrument Inc.) for his technical advice and help during the process of this research.
- 3.R. Yang, et al., “Analysis of keratinocytes stiffness after desmosome disruption using Atomic Force Microscopy based nanomanipulation,” IEEE Int. Conf. Nanotechnology, Genoa, Italy, July 2009.Google Scholar
- 6.R. Yang, N. Xi, C. Fung, K. Seiffert-Sinha, K. Lai and A. Sinha, “The emergence of AFM applications to cell biology: how new technologies are facilitating investigation of human cells in health and disease at the nanoscale,” Journal of Nanoscience Letters, vol. 1, 2011, pp. 81–101.CrossRefGoogle Scholar
- 13.DE. Discher, N. Mohandas, EA. Evans “Molecular maps of red cell deformation: hidden elasticity and in situ connectivity,” Science, vol. 266–5187, 1994, pp. 1032–1035.Google Scholar
- 14.J. Stroscio and D. M. Eigler, “Atomic and molecular manipulation with the scanning tunneling microscope,” Science, vol. 254, no. 5036, Nov, 1991, pp. 1319–1326.Google Scholar
- 17.D.J. Muller and Yves F. Dufrene, “Atomic force microscopy as a multifunctional molecular toolbox in nanobiotechnology,” Nat. Nanotechnol, vol. 3, May 2008, pp. 261–269.Google Scholar
- 18.L. Liu, N. Xi, Y. Luo, J. Zhang, G. Li, “Sensor referenced guidance and control for robotic nanomanipulation,” IEEE International Conference on Intelligent Robots and Systems, 2007, pp. 578–583.Google Scholar
- 20.B. Song, N. Xi, R. Yang, K. W. C. Lai and C. Qu, “On-line sensing and visual feedback for atomic force microscopy (afm) based nano-manipulations,” IEEE Int. Conf. Nanotechnology Materials and Devices (NMDC), Oct 2010, pp. 71–74.Google Scholar