Abstract
At one time, primary (non-Hodgkin’s) lymphoma of the thyroid gland was considered to be a rare thyroid malignancy. However, in recent years it has been estimated that it may account for 5% to 10% of thyroid cancers. Among patients with a solitary discrete nodule of the thyroid gland, the incidence of primary lymphoma is 1 in 1000. In patients with diffuse goiters, the incidence of primary lymphoma is 1 in 100. Primary lymphomas of the thyroid land are said to constitute only 1.3% to 6.5% of all extranodal lymphomas. The reported mean age at the time of diagnosis is approximately 60 to 65 years with a range of 10 years to 90 years. The female-to-male ratio ranges from 3:1 to 18:1 but in the subgroup aged 60 years or less the ratio narrows toward 1:1. Approximately 40% of patients are under the age of 60 years at the time of diagnosis.1–18
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References
Welch JW, Chesky VE, Hellwig CA. Malignant lymphoma of the thyroid. Surg Gynecol Obstet 1958; 106: 70–76.
Roberts L, Primary reticulosarcoma of the thyroid gland. Postgrad Med J 1961; 37: 481–484.
Crile G Jr. Lymphosarcoma and reticulum cell sarcoma of the thyroid. Surg Gynecol Obstet 1963; 116: 449–450.
Mikal S. Primary lymphoma of the thyroid gland. Surgery 1964; 55: 233–239.
Woolner LB, McConahey WM, Beahrs OH, Black BM. Primary malignant lymphoma of the thyroid: review of forty-six cases. Am J Surg 1966; 111: 502–523.
Slimkin PM, Sagerman RH, Lymphoma of the thyroid gland. Radiology 1969; 92: 312–316.
Smithers DW. Malignant lymphomas of the thyroid gland. Eng Monogr Neoplast Dis Var Sites 1970; 6: 141–154.
Burke JS, Butler JJ, Fuller LM. Malignant lymphomas of the thyroid: a clinical pathologic study of 35 patients including ultrastructural observations. Cancer 1977; 39: 1587–1602.
Devine RM, Edis AJ, Banks PM. Primary lymphoma of the thyroid: a review of the Mayo Clinic experience through 1978. World J Surg 1981; 5: 33–38.
Sirota DK, Segal RL. Primary lymphoma of the thyroid gland. JAMA 1979; 242: 1743–1746.
Compagno J, Oertel JE. Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland. Am J Clin Pathol 1980; 74: 1–11.
Grimley RP, Oates GD. The natural history of malignant thyroid lymphomas. Br J Surg 1980; 67: 475–477.
Williams ED. Malignant lymphoma of the thyroid. Clin Endocrinol Metab 1981; 10: 379–389.
Miller JM, Kini SR, Rebuck J, Hamburger JI. Is lymphoma of the thyroid a disease which is increasing in frequency? In: Hamburger JI, Miller JM, eds. Controversies in Clinical Thyroidology. New York: Springer-Verlag; 1981: 267–297.
Hamburger JI, Miller JM, Kini SR. Lymphoma of the thyroid. Ann Intern Med 1983; 99: 685–693.
DeGroot LJ, Larsen PR, Refetoff S, Stanbury JB. The Thyroid and Its Diseases. 5th ed. New York: John Wiley; 1984.
Rasbach DA, Mondschein MS, Harris NL, Kaufman DS, Wang CA. Malignant lymphoma of the thyroid gland: a clinical and pathologic study of twenty cases. Surgery 1985; 98: 1166–1170.
Tupchong L, Hughes F, Harmer CL. Primary lymphoma of the thyroid: clinical features, prognostic factors, and results of treatment. Int J Radiat Oncol Biol Phys 1986; 12: 1813–1821.
Butler JS, Brady LW, Amendola BE. Lymphoma of the thyroid-report of five cases and review. Am J Clin Oncol 1990; 13: 64–69.
Graham CP. Hoarseness associated with lymphoma of the thyroid gland. South Med J 1982; 75: 1566–1567.
Watson C. Laryngeal oedema complicating thyroid lymphoma. J Laryngol Otol 1988; 102: 947–948.
Van Ruiswyk J, Cunningham C, Cerletty J. Obstructive manifestations of thyroid lymphoma. Arch Intern Med 1989; 149: 1575–1577.
Jennings AS, Saberi M. Thyroid lymphoma in a patient with hyperthyroidism. Am J Med 1984; 76: 551–552.
Parulekar SG, Katzman RA. Primary malignant lymphoma of the thyroid: sonographic appearance. JCU 1986; 14: 60–62.
Hamada S, Ikeda H, Masaki N, Kozuka T, Matsuzuka F. Comparison of CT and US assessment. Radiology 1989; 171: 439–443.
Takashima S, Ikezoe J, Morimoto S, et al. Primary thyroid lymphoma: Evaluation with CT. Radiology 1988; 168: 765–768.
Takashima S, Ikezoe J, Morimoto S, Harada K, Kozuka T, Matsuzuka F. MR imaging of primary thyroid lymphoma. J Comp Assist Tomogr 1989; 13: 517–518.
Higashi T, Ito K, Nishikawa Y, et al. Gallium-67 imaging in the evaluation of thyroid malignancy. Clin Nucl Med 1988; 13: 792–799.
Hyjek E, Isaacson PG. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto’s thyroiditis. Hum Pathol 1988; 19: 1315–1326.
Aozasa K, Inoue A, Tajima K, Miyauchi A, Matsuzuka F, Kuma K. Malignant lymphomas of the thyroid gland. Analysis of 79 patients with emphasis on histologic prognostic factors. Cancer 1986; 58: 100–104.
Shinomiya S, Sumitomo M, Kudo E, Sakaki A, Hizawa K. Malignant thyroid neoplasms and coexistent lymphocytic thyroiditis. Tokushima J Exp Med 1988; 35: 91–100.
Willems JS, Lowhagen T. The role of fine-needle aspiration cytology in the management of thyroid disease. Clin Endocrinol Metab 1981; 10: 267–273.
Tani E, Skoog L. Fine needle aspiration cytology and immunocytochemistry in the diagnosis of lymphoid lesions of the thyroid gland. Acta Cytol 1989; 33: 48–52.
Limanova Z, Neuwirtovar R, Smejkal V. Malignant lymphoma of the thyroid. Exp Clin Endocrinol 1987; 90: 113–119.
Matsuda M, Sone H, Koyama H, Ishiguro S. Fineneedle aspiration cytology of malignant lymphoma of the thyroid. Diagn Cytopathol 1987; 3: 244–249.
Harasch HR, Williams ED. Fibrous thyroiditis—An immunopathological study. Histopathology 1983; 7: 739–751.
Schwaegenle SM, Bauer TW, Esselstyn CB. Riedel’s thyroiditis. Am J Clin Pathol 1988; 90: 715–722.
Mizukami Y, Ikuta N, Hashimoto T et al. Pseudolymphoma of the thyroid. Acta Pathol Jpn. 1988; 38: 1329–1336.
Rayfield EJ, Nishiyama RH, Sisson JC. Small cell tumors of the thyroid: a clinicopathologic study. Cancer 1971; 28: 1023–1030.
Heimann R, Vannineuse A, De Sloover C, Dor P. Malignant lymphoma and undifferentiated small ceil carcinoma of the thyroid: a clinicopathological review in the light of the Kiel classification for malignant lymphoma. Histopathology 1978; 2: 201–213.
Tobler A, Maurer R, Hedinger CE. Undifferentiated thyroid tumors of diffuse small cell type: histological and immunohistochemical evidence for their lymphomatous nature. Virchows Arch [A] 1984; 404: 117–126.
Schmid KW, Kroll M, Hofstadter F, Ladurner D. Small cell carcinoma of the thyroid. A reclassification of cases originally diagnosed as small cell carcinomas of the thyroid. Pathol Res Pract 1986; 181: 540–543.
Souhami L, Simpson WJ, Carruthers JS. Malignant lymphoma of the thyroid gland. Int J Radiat Oncol Biol Phys 1980; 6: 1143–1147.
Blair TJ, Evans RG, Buskirk SJ, Banks PM, Earle JD. Radiotherapeutic management of primary thyroid lymphoma. Int J Radiat Oncol Biol Phys 1985; 11: 365–370.
National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphoma. Summary and description of a working formulation for clinical usage. Cancer 1982; 49: 2112–2135.
Gerard-Marchant R, Hamlin I, Lennert K, Rilke F, Stansfeld AG, Van Unnik JAM. Classification of non-Hodgkin’s lymphomas. Lancet 1974; 2: 405–408.
Lennert K, Stein H, Kaiserling E. Cytological and functional criteria for the classification of malignant lymphomata. Br J Cancer 1975; 31 (suppl II): 29–42.
Anscombe AM, Wright DH. Primary malignant lymphoma of the thyroid—a tumor of mucosa-associated lymphoid tissue: review of seventy-six cases. Histopathology 1985; 9: 81–97.
Aozasa K, Inoue A, Yoshimuru H et al. Intermediate lymphocytic lymphoma of the thyroid. An Immunologic and immunohistologic study. Cancer 1986; 57: 1762–1767.
Aozasa K, Ueda T, Katagiri S, Matsuzuka F, Kuma K, Yonezawa T. Immunologic and immunohistologic analysis of 27 cases with thyroid lymphomas. Cancer 1987; 60: 969–973
Kato I, Tajima K, Suchi T et al. Chronic thyroiditis as a risk factor of B-cell lymphoma in the thyroid gland. Jpn J Cancer Res 1985; 76: 1085–1090.
Matsubayashi S, Tamai H, Keisuke N, Kuma K, Nakagawa T. Monoclonal gammopathy in Hashimoto’s thyroiditis and malignant lymphoma of the thyroid. J Clin Endocrinol Metab 1986; 63: 1136–1139.
Faure P, Chittal S, Woodman-Memeteau F et al. Diagnostic features of primary malignant lymphomas of the thyroid with monoclonal antibodies. Cancer 1988; 61: 1852–1861.
Bisbee AC, Thoeny RH. Malignant lymphoma of the thyroid gland following irradiation Cancer 1975; 35: 1296–1299.
Aozasa K, Inoue A, Yoshimura H, Miyauchi A, Matsuzuka F, Kuma K, Plasmacytoma of the thyroid gland. Cancer 1986; 58: 105–110.
Holm LE, Blomgren H, Lowhagen T. Cancer risks in patients with chronic lymphocytic thyroiditis. N Engl J Med 1985; 312: 601–604.
Taniwaki M, Nishida K, Misawa S et al. Correlation of chromosome abnormalities with clinical characteristics in thyroid lymphoma. Cancer 1989; 63: 873–876.
Matsubayashi S, Tamai H, Morita T et al. Malignant lymphoma of the thyroid and Epstein-Barr virus. Endocrinol Japan 1989; 36: 343–348.
Rosen IB, Sutcliffe SB, Gospodarowicz MK, Chua T, Simpson JK. The role of surgery in the management of thyroid lymphoma. Surgery 1988; 104: 1095–1099.
Vigliotti A, Kong JS, Fuller LM, Velasquez WS. Thyroid lymphomas stages Ie and He: comparative results for radiotherapy only, combination chemotherapy only, and multimodality treatment. Int J Radiat Oncol Biol Phys 1986; 12: 1807–1812.
Connors JM, Klimo P, Fairey RN, Voss N. Brief chemotherapy and involved field radiation therapy for limited-stage, histologically aggressive lymphoma. Ann Intern Med 1987; 107: 25–30.
Ikeda H, Masaki N, Aozasa K. Results of the treatment of localized non-Hodgkin’s lymphoma originated in the thyroid gland. Gan No Rinsho 1988; 34: 637–643.
Leedman PJ, Sheridan WP, Downey WF, Fox RM, Martin IR. Combination chemotherapy for stage IE and HE thyroid lymphoma. Med J Aust 1990; 152: 40–43.
Voegt H. Extramedullae plasmocytome. Virchows Arch Pathol Anat 1938; 302: 497–508.
Hazard JB, Schildecker WW. Plasmacytoma of the thyroid. Am J Pathol 1949; 25: 819–820.
Macpherson TA, Dekker A, Kapadia SB. Thyroidgland plasma cell neoplasm (plasmacytoma). Arch Pathol Lab Med 1981; 105: 570–572.
Aozas K, Inoue A, Yoshimura H, Miyauchi A, Matsuzuka F, Kuma K. Plasmacytoma of the thyroid gland. Cancer 1986; 58: 105–110.
Chen KTK, Bauer V, Bauer F. Localized thyroid plasmacytoma. J Surg Oncol 1986; 32: 220–222.
Beguin Y, Boniver J, Buri J et al. Plasmactyoma of the thyroid: A case report, a study with use of the immunoperoxydase technique and a review of the literature. Surgery 1987; 101: 496–500.
Yashiro T, Aiba M, Obara T, Fujimoto Y, Hirayama A. IgG-Kappa-producing primary plasmacytoma of the thyroid gland with preoperative serum M protein. Acta Pathol Jpn 1988; 38: 371–381.
Aozasa K, Inoue A, Katagiri S, Matsuzuka F, Katayama S, Yonezawa T. Plasmacytoma and follicular lymphoma in a case of Hashimoto’s thyroiditis. Histopathology 1986; 10: 735–740.
Caron P, Lassoued S, Thibaut I, Fournie B, Fournie A. Thyroid plasmacytoma with dermatomyositis and palmar fasciitis. J Rheumatol 1989; 16: 997–999.
Salazar JE, Nelson JF, Winer-Muram HT. Extramedullary plasmacytoma of the thyroid. J Can Assoc Radiol 1987; 38: 135–137.
Baba T, Watanabe M, Hotchi M, Miyagawa A. An autopsy case of plasmacytoma of the thyroid gland. Gan No Rinsho 1987; 33: 392–398.
Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer 1972; 29: 252–260.
Kim YH, Fayos JV, Schnitzer B. Extranodal head & neck lymphomas: results of radiation therapy. Int J Radiat Oncol Biol Phys 1978; 4: 789–794.
Roberts TW, Howard RG. Primary Hodgkin’s disease of the thyroid: Report of a case and review of the literature. Ann Surg 1963; 157: 625–632.
Gibson JM, Prinn MG. Hodgkin’s disease involving the thyroid gland. Br J Surg 1968; 55: 236–239.
Abel WG, Finnerty J. Primary Hodgkin’s disease of thyroid. NY State J Med 1969; 314–315.
Ackerman LV, del Regato JA. Cancer; diagnosis, treatment and prognosis. 2nd ed. St. Louis: MO The C.V. Mosby Company; 1954.
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Sirota, D.K. (1992). Lymphoma of the Thyroid Gland. In: Cobin, R.H., Sirota, D.K. (eds) Malignant Tumors of the Thyroid. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9127-2_10
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DOI: https://doi.org/10.1007/978-1-4613-9127-2_10
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