Skip to main content

Lymphoma of the Thyroid Gland

  • Chapter
Malignant Tumors of the Thyroid
  • 45 Accesses

Abstract

At one time, primary (non-Hodgkin’s) lymphoma of the thyroid gland was considered to be a rare thyroid malignancy. However, in recent years it has been estimated that it may account for 5% to 10% of thyroid cancers. Among patients with a solitary discrete nodule of the thyroid gland, the incidence of primary lymphoma is 1 in 1000. In patients with diffuse goiters, the incidence of primary lymphoma is 1 in 100. Primary lymphomas of the thyroid land are said to constitute only 1.3% to 6.5% of all extranodal lymphomas. The reported mean age at the time of diagnosis is approximately 60 to 65 years with a range of 10 years to 90 years. The female-to-male ratio ranges from 3:1 to 18:1 but in the subgroup aged 60 years or less the ratio narrows toward 1:1. Approximately 40% of patients are under the age of 60 years at the time of diagnosis.1–18

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Welch JW, Chesky VE, Hellwig CA. Malignant lymphoma of the thyroid. Surg Gynecol Obstet 1958; 106: 70–76.

    PubMed  CAS  Google Scholar 

  2. Roberts L, Primary reticulosarcoma of the thyroid gland. Postgrad Med J 1961; 37: 481–484.

    Article  PubMed  CAS  Google Scholar 

  3. Crile G Jr. Lymphosarcoma and reticulum cell sarcoma of the thyroid. Surg Gynecol Obstet 1963; 116: 449–450.

    PubMed  Google Scholar 

  4. Mikal S. Primary lymphoma of the thyroid gland. Surgery 1964; 55: 233–239.

    PubMed  CAS  Google Scholar 

  5. Woolner LB, McConahey WM, Beahrs OH, Black BM. Primary malignant lymphoma of the thyroid: review of forty-six cases. Am J Surg 1966; 111: 502–523.

    Article  PubMed  CAS  Google Scholar 

  6. Slimkin PM, Sagerman RH, Lymphoma of the thyroid gland. Radiology 1969; 92: 312–316.

    Google Scholar 

  7. Smithers DW. Malignant lymphomas of the thyroid gland. Eng Monogr Neoplast Dis Var Sites 1970; 6: 141–154.

    CAS  Google Scholar 

  8. Burke JS, Butler JJ, Fuller LM. Malignant lymphomas of the thyroid: a clinical pathologic study of 35 patients including ultrastructural observations. Cancer 1977; 39: 1587–1602.

    Article  PubMed  CAS  Google Scholar 

  9. Devine RM, Edis AJ, Banks PM. Primary lymphoma of the thyroid: a review of the Mayo Clinic experience through 1978. World J Surg 1981; 5: 33–38.

    Article  PubMed  CAS  Google Scholar 

  10. Sirota DK, Segal RL. Primary lymphoma of the thyroid gland. JAMA 1979; 242: 1743–1746.

    Article  PubMed  CAS  Google Scholar 

  11. Compagno J, Oertel JE. Malignant lymphoma and other lymphoproliferative disorders of the thyroid gland. Am J Clin Pathol 1980; 74: 1–11.

    PubMed  CAS  Google Scholar 

  12. Grimley RP, Oates GD. The natural history of malignant thyroid lymphomas. Br J Surg 1980; 67: 475–477.

    Article  PubMed  CAS  Google Scholar 

  13. Williams ED. Malignant lymphoma of the thyroid. Clin Endocrinol Metab 1981; 10: 379–389.

    Article  PubMed  CAS  Google Scholar 

  14. Miller JM, Kini SR, Rebuck J, Hamburger JI. Is lymphoma of the thyroid a disease which is increasing in frequency? In: Hamburger JI, Miller JM, eds. Controversies in Clinical Thyroidology. New York: Springer-Verlag; 1981: 267–297.

    Chapter  Google Scholar 

  15. Hamburger JI, Miller JM, Kini SR. Lymphoma of the thyroid. Ann Intern Med 1983; 99: 685–693.

    PubMed  CAS  Google Scholar 

  16. DeGroot LJ, Larsen PR, Refetoff S, Stanbury JB. The Thyroid and Its Diseases. 5th ed. New York: John Wiley; 1984.

    Google Scholar 

  17. Rasbach DA, Mondschein MS, Harris NL, Kaufman DS, Wang CA. Malignant lymphoma of the thyroid gland: a clinical and pathologic study of twenty cases. Surgery 1985; 98: 1166–1170.

    PubMed  CAS  Google Scholar 

  18. Tupchong L, Hughes F, Harmer CL. Primary lymphoma of the thyroid: clinical features, prognostic factors, and results of treatment. Int J Radiat Oncol Biol Phys 1986; 12: 1813–1821.

    Article  PubMed  CAS  Google Scholar 

  19. Butler JS, Brady LW, Amendola BE. Lymphoma of the thyroid-report of five cases and review. Am J Clin Oncol 1990; 13: 64–69.

    Article  PubMed  Google Scholar 

  20. Graham CP. Hoarseness associated with lymphoma of the thyroid gland. South Med J 1982; 75: 1566–1567.

    Article  PubMed  Google Scholar 

  21. Watson C. Laryngeal oedema complicating thyroid lymphoma. J Laryngol Otol 1988; 102: 947–948.

    PubMed  CAS  Google Scholar 

  22. Van Ruiswyk J, Cunningham C, Cerletty J. Obstructive manifestations of thyroid lymphoma. Arch Intern Med 1989; 149: 1575–1577.

    Article  PubMed  Google Scholar 

  23. Jennings AS, Saberi M. Thyroid lymphoma in a patient with hyperthyroidism. Am J Med 1984; 76: 551–552.

    Article  PubMed  CAS  Google Scholar 

  24. Parulekar SG, Katzman RA. Primary malignant lymphoma of the thyroid: sonographic appearance. JCU 1986; 14: 60–62.

    PubMed  CAS  Google Scholar 

  25. Hamada S, Ikeda H, Masaki N, Kozuka T, Matsuzuka F. Comparison of CT and US assessment. Radiology 1989; 171: 439–443.

    PubMed  Google Scholar 

  26. Takashima S, Ikezoe J, Morimoto S, et al. Primary thyroid lymphoma: Evaluation with CT. Radiology 1988; 168: 765–768.

    PubMed  CAS  Google Scholar 

  27. Takashima S, Ikezoe J, Morimoto S, Harada K, Kozuka T, Matsuzuka F. MR imaging of primary thyroid lymphoma. J Comp Assist Tomogr 1989; 13: 517–518.

    Article  CAS  Google Scholar 

  28. Higashi T, Ito K, Nishikawa Y, et al. Gallium-67 imaging in the evaluation of thyroid malignancy. Clin Nucl Med 1988; 13: 792–799.

    Article  PubMed  CAS  Google Scholar 

  29. Hyjek E, Isaacson PG. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto’s thyroiditis. Hum Pathol 1988; 19: 1315–1326.

    Article  PubMed  CAS  Google Scholar 

  30. Aozasa K, Inoue A, Tajima K, Miyauchi A, Matsuzuka F, Kuma K. Malignant lymphomas of the thyroid gland. Analysis of 79 patients with emphasis on histologic prognostic factors. Cancer 1986; 58: 100–104.

    Article  PubMed  CAS  Google Scholar 

  31. Shinomiya S, Sumitomo M, Kudo E, Sakaki A, Hizawa K. Malignant thyroid neoplasms and coexistent lymphocytic thyroiditis. Tokushima J Exp Med 1988; 35: 91–100.

    PubMed  CAS  Google Scholar 

  32. Willems JS, Lowhagen T. The role of fine-needle aspiration cytology in the management of thyroid disease. Clin Endocrinol Metab 1981; 10: 267–273.

    Article  PubMed  CAS  Google Scholar 

  33. Tani E, Skoog L. Fine needle aspiration cytology and immunocytochemistry in the diagnosis of lymphoid lesions of the thyroid gland. Acta Cytol 1989; 33: 48–52.

    PubMed  CAS  Google Scholar 

  34. Limanova Z, Neuwirtovar R, Smejkal V. Malignant lymphoma of the thyroid. Exp Clin Endocrinol 1987; 90: 113–119.

    Article  PubMed  CAS  Google Scholar 

  35. Matsuda M, Sone H, Koyama H, Ishiguro S. Fineneedle aspiration cytology of malignant lymphoma of the thyroid. Diagn Cytopathol 1987; 3: 244–249.

    Article  PubMed  CAS  Google Scholar 

  36. Harasch HR, Williams ED. Fibrous thyroiditis—An immunopathological study. Histopathology 1983; 7: 739–751.

    Article  Google Scholar 

  37. Schwaegenle SM, Bauer TW, Esselstyn CB. Riedel’s thyroiditis. Am J Clin Pathol 1988; 90: 715–722.

    Google Scholar 

  38. Mizukami Y, Ikuta N, Hashimoto T et al. Pseudolymphoma of the thyroid. Acta Pathol Jpn. 1988; 38: 1329–1336.

    PubMed  CAS  Google Scholar 

  39. Rayfield EJ, Nishiyama RH, Sisson JC. Small cell tumors of the thyroid: a clinicopathologic study. Cancer 1971; 28: 1023–1030.

    Article  PubMed  CAS  Google Scholar 

  40. Heimann R, Vannineuse A, De Sloover C, Dor P. Malignant lymphoma and undifferentiated small ceil carcinoma of the thyroid: a clinicopathological review in the light of the Kiel classification for malignant lymphoma. Histopathology 1978; 2: 201–213.

    Article  PubMed  CAS  Google Scholar 

  41. Tobler A, Maurer R, Hedinger CE. Undifferentiated thyroid tumors of diffuse small cell type: histological and immunohistochemical evidence for their lymphomatous nature. Virchows Arch [A] 1984; 404: 117–126.

    Article  CAS  Google Scholar 

  42. Schmid KW, Kroll M, Hofstadter F, Ladurner D. Small cell carcinoma of the thyroid. A reclassification of cases originally diagnosed as small cell carcinomas of the thyroid. Pathol Res Pract 1986; 181: 540–543.

    PubMed  CAS  Google Scholar 

  43. Souhami L, Simpson WJ, Carruthers JS. Malignant lymphoma of the thyroid gland. Int J Radiat Oncol Biol Phys 1980; 6: 1143–1147.

    Article  PubMed  CAS  Google Scholar 

  44. Blair TJ, Evans RG, Buskirk SJ, Banks PM, Earle JD. Radiotherapeutic management of primary thyroid lymphoma. Int J Radiat Oncol Biol Phys 1985; 11: 365–370.

    Article  PubMed  CAS  Google Scholar 

  45. National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphoma. Summary and description of a working formulation for clinical usage. Cancer 1982; 49: 2112–2135.

    Article  Google Scholar 

  46. Gerard-Marchant R, Hamlin I, Lennert K, Rilke F, Stansfeld AG, Van Unnik JAM. Classification of non-Hodgkin’s lymphomas. Lancet 1974; 2: 405–408.

    Google Scholar 

  47. Lennert K, Stein H, Kaiserling E. Cytological and functional criteria for the classification of malignant lymphomata. Br J Cancer 1975; 31 (suppl II): 29–42.

    Google Scholar 

  48. Anscombe AM, Wright DH. Primary malignant lymphoma of the thyroid—a tumor of mucosa-associated lymphoid tissue: review of seventy-six cases. Histopathology 1985; 9: 81–97.

    Article  PubMed  CAS  Google Scholar 

  49. Aozasa K, Inoue A, Yoshimuru H et al. Intermediate lymphocytic lymphoma of the thyroid. An Immunologic and immunohistologic study. Cancer 1986; 57: 1762–1767.

    Article  PubMed  CAS  Google Scholar 

  50. Aozasa K, Ueda T, Katagiri S, Matsuzuka F, Kuma K, Yonezawa T. Immunologic and immunohistologic analysis of 27 cases with thyroid lymphomas. Cancer 1987; 60: 969–973

    Article  PubMed  CAS  Google Scholar 

  51. Kato I, Tajima K, Suchi T et al. Chronic thyroiditis as a risk factor of B-cell lymphoma in the thyroid gland. Jpn J Cancer Res 1985; 76: 1085–1090.

    PubMed  CAS  Google Scholar 

  52. Matsubayashi S, Tamai H, Keisuke N, Kuma K, Nakagawa T. Monoclonal gammopathy in Hashimoto’s thyroiditis and malignant lymphoma of the thyroid. J Clin Endocrinol Metab 1986; 63: 1136–1139.

    Article  PubMed  CAS  Google Scholar 

  53. Faure P, Chittal S, Woodman-Memeteau F et al. Diagnostic features of primary malignant lymphomas of the thyroid with monoclonal antibodies. Cancer 1988; 61: 1852–1861.

    Article  PubMed  CAS  Google Scholar 

  54. Bisbee AC, Thoeny RH. Malignant lymphoma of the thyroid gland following irradiation Cancer 1975; 35: 1296–1299.

    CAS  Google Scholar 

  55. Aozasa K, Inoue A, Yoshimura H, Miyauchi A, Matsuzuka F, Kuma K, Plasmacytoma of the thyroid gland. Cancer 1986; 58: 105–110.

    Article  PubMed  CAS  Google Scholar 

  56. Holm LE, Blomgren H, Lowhagen T. Cancer risks in patients with chronic lymphocytic thyroiditis. N Engl J Med 1985; 312: 601–604.

    Article  PubMed  CAS  Google Scholar 

  57. Taniwaki M, Nishida K, Misawa S et al. Correlation of chromosome abnormalities with clinical characteristics in thyroid lymphoma. Cancer 1989; 63: 873–876.

    Article  PubMed  CAS  Google Scholar 

  58. Matsubayashi S, Tamai H, Morita T et al. Malignant lymphoma of the thyroid and Epstein-Barr virus. Endocrinol Japan 1989; 36: 343–348.

    Article  CAS  Google Scholar 

  59. Rosen IB, Sutcliffe SB, Gospodarowicz MK, Chua T, Simpson JK. The role of surgery in the management of thyroid lymphoma. Surgery 1988; 104: 1095–1099.

    PubMed  CAS  Google Scholar 

  60. Vigliotti A, Kong JS, Fuller LM, Velasquez WS. Thyroid lymphomas stages Ie and He: comparative results for radiotherapy only, combination chemotherapy only, and multimodality treatment. Int J Radiat Oncol Biol Phys 1986; 12: 1807–1812.

    Article  PubMed  CAS  Google Scholar 

  61. Connors JM, Klimo P, Fairey RN, Voss N. Brief chemotherapy and involved field radiation therapy for limited-stage, histologically aggressive lymphoma. Ann Intern Med 1987; 107: 25–30.

    PubMed  CAS  Google Scholar 

  62. Ikeda H, Masaki N, Aozasa K. Results of the treatment of localized non-Hodgkin’s lymphoma originated in the thyroid gland. Gan No Rinsho 1988; 34: 637–643.

    PubMed  CAS  Google Scholar 

  63. Leedman PJ, Sheridan WP, Downey WF, Fox RM, Martin IR. Combination chemotherapy for stage IE and HE thyroid lymphoma. Med J Aust 1990; 152: 40–43.

    PubMed  CAS  Google Scholar 

  64. Voegt H. Extramedullae plasmocytome. Virchows Arch Pathol Anat 1938; 302: 497–508.

    Article  Google Scholar 

  65. Hazard JB, Schildecker WW. Plasmacytoma of the thyroid. Am J Pathol 1949; 25: 819–820.

    Google Scholar 

  66. Macpherson TA, Dekker A, Kapadia SB. Thyroidgland plasma cell neoplasm (plasmacytoma). Arch Pathol Lab Med 1981; 105: 570–572.

    PubMed  CAS  Google Scholar 

  67. Aozas K, Inoue A, Yoshimura H, Miyauchi A, Matsuzuka F, Kuma K. Plasmacytoma of the thyroid gland. Cancer 1986; 58: 105–110.

    Article  Google Scholar 

  68. Chen KTK, Bauer V, Bauer F. Localized thyroid plasmacytoma. J Surg Oncol 1986; 32: 220–222.

    Article  PubMed  CAS  Google Scholar 

  69. Beguin Y, Boniver J, Buri J et al. Plasmactyoma of the thyroid: A case report, a study with use of the immunoperoxydase technique and a review of the literature. Surgery 1987; 101: 496–500.

    PubMed  CAS  Google Scholar 

  70. Yashiro T, Aiba M, Obara T, Fujimoto Y, Hirayama A. IgG-Kappa-producing primary plasmacytoma of the thyroid gland with preoperative serum M protein. Acta Pathol Jpn 1988; 38: 371–381.

    PubMed  CAS  Google Scholar 

  71. Aozasa K, Inoue A, Katagiri S, Matsuzuka F, Katayama S, Yonezawa T. Plasmacytoma and follicular lymphoma in a case of Hashimoto’s thyroiditis. Histopathology 1986; 10: 735–740.

    Article  PubMed  CAS  Google Scholar 

  72. Caron P, Lassoued S, Thibaut I, Fournie B, Fournie A. Thyroid plasmacytoma with dermatomyositis and palmar fasciitis. J Rheumatol 1989; 16: 997–999.

    PubMed  CAS  Google Scholar 

  73. Salazar JE, Nelson JF, Winer-Muram HT. Extramedullary plasmacytoma of the thyroid. J Can Assoc Radiol 1987; 38: 135–137.

    Google Scholar 

  74. Baba T, Watanabe M, Hotchi M, Miyagawa A. An autopsy case of plasmacytoma of the thyroid gland. Gan No Rinsho 1987; 33: 392–398.

    PubMed  CAS  Google Scholar 

  75. Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer 1972; 29: 252–260.

    Article  PubMed  CAS  Google Scholar 

  76. Kim YH, Fayos JV, Schnitzer B. Extranodal head & neck lymphomas: results of radiation therapy. Int J Radiat Oncol Biol Phys 1978; 4: 789–794.

    PubMed  CAS  Google Scholar 

  77. Roberts TW, Howard RG. Primary Hodgkin’s disease of the thyroid: Report of a case and review of the literature. Ann Surg 1963; 157: 625–632.

    Article  PubMed  CAS  Google Scholar 

  78. Gibson JM, Prinn MG. Hodgkin’s disease involving the thyroid gland. Br J Surg 1968; 55: 236–239.

    Article  PubMed  CAS  Google Scholar 

  79. Abel WG, Finnerty J. Primary Hodgkin’s disease of thyroid. NY State J Med 1969; 314–315.

    Google Scholar 

  80. Ackerman LV, del Regato JA. Cancer; diagnosis, treatment and prognosis. 2nd ed. St. Louis: MO The C.V. Mosby Company; 1954.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag New York Inc.

About this chapter

Cite this chapter

Sirota, D.K. (1992). Lymphoma of the Thyroid Gland. In: Cobin, R.H., Sirota, D.K. (eds) Malignant Tumors of the Thyroid. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9127-2_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-9127-2_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9129-6

  • Online ISBN: 978-1-4613-9127-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics