Regulation and Expression of Thyroid Stimulating Hormone

  • Bruce D. Weintraub
  • Myung K. Kim
  • Donald L. Bodenner
  • N. Rao Thotakura
  • Mariusz W. Szkudlinski
  • Lata Joshi
  • Yoko Murata
Conference paper
Part of the Serono Symposia USA book series (SERONOSYMP)


Thyroid stimulating hormone (TSH) is an anterior pituitary hormone that stimulates thyroid hormone production (1). It is composed of two subunits: the alpha subunit, which is in common with the gonadotropins, luteinizing hormone, and follicle stimulating hormone; and the unique beta subunit, which confers biological specificity to the intact hormone and is expressed exclusively in the thyrotropes of the anterior pituitary (2). Previous studies have indicated that the transcription of the TSHβ gene is stimulated by thyrotropin releasing hormone (TRH) (3–6), phorbol esters (5, 7), and the adenylyl cyclase activator, forskolin, or the cAMP analog 8-bromo-cAMP (4–6, 8), and is inhibited by thyroid hormone (9–15).


Thyroid Stimulate Hormone Phorbol Ester Thyrotropin Release Hormone Sialic Acid Content Thyrotropin Release Hormone 
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Copyright information

© Springer-Verlag New York, Inc. 1994

Authors and Affiliations

  • Bruce D. Weintraub
  • Myung K. Kim
  • Donald L. Bodenner
  • N. Rao Thotakura
  • Mariusz W. Szkudlinski
  • Lata Joshi
  • Yoko Murata

There are no affiliations available

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