Anticonvulsant-Convulsant Effects of Delta-9-Tetrahydrocannabinol
It is fairly well established that delta-9-tetrahydrocannabinol (delta-9-THC), the major psychoactive constituent of marihuana, has anticonvulsant properties. A summary of the reported effects of delta-9-THC in laboratory animals for a variety of experimentally induced seizure paradigms is presented in Table 1. In general, behavioral seizures in rodents, frogs, and cats, and electrographic seizures in rats and cats produced by electrical stimulation are prevented by delta-9-THC. Additionally, auditory, tactile (reflex), and in some cases pentylenetetrazol (PTZ) induced seizures in rodents are also blocked by the cannabinoid.
KeywordsAnticonvulsant Activity Audiogenic Seizure Apply Pharmacology Maximal Electroshock Electrographic Seizure
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