Multiple Actions of Amantadine Against Influenza Viruses
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The data presented in this paper distinguish two actions of amantadine on the replication of fowl plague virus in tissue culture which occur at different concentrations. Low concentrations (approximately 5 μM) appear to inhibit the assembly of fowl plague virus by interacting with the virus haemagglutinin. In contrast, concentrations of 0.5 mM or greater, which have no effect on virus assembly, inhibit an early stage in infection which may involve low pH-dependent fusion between the virus envelope and the membrane of secondary lysosomes (1, 2). Whereas most influenza viruses display the latter sensitivity to amantadine they differ greatly in their susceptibility to low concentrations of the drug. The replication of certain human influenza viruses, e.g. A/Singapore/1/57 (H2N2), is also affected by low drug concentrations at an early stage prior to primary transcription. This action which is dependent on properties of the matrix protein appears different from that of high concentrations of amantadine.
KeywordsInfluenza Virus Avian Influenza Virus Yield Human Influenza Virus Primary Transcription
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