Most of the broad aspects of the life cycle of Trichinella were uncovered during the 50 years following its discovery and description by Paget and Owen in 1835 and are highlighted in Chapter 1, which deals with the history of this nematode. Nevertheless, many details of its enterai and parenteral life were not described until after 1960, and many have yet to be described. For instance, it is now known that Trichinella lives as an intracellular parasite, except for its brief life as a migratory newborn larva, making it the largest example of this type of commonly occurring organism. These findings have radically influenced thinking concerning the specific ways in which Trichinella derives its livelihood from the host.


Adult Worm Transmission Electron Micrograph Thoracic Duct Nurse Cell Female Worm 
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  1. Alicata, J.E., 1935, Infectivity of Trichinella spiralis after successive feedings to rabbits, J. Parasitol. 21: 431.Google Scholar
  2. Ali Khan, Z., 1966, The post-embryonic development of Trichinella spiralis with special reference to ecdysis, J. Parasitol. 52: 248–259.CrossRefGoogle Scholar
  3. Askanazy, M., 1895, Zur Lehre von der Trichinosis, Virchows Arch. Pathol. Anat. 141: 42–71.CrossRefGoogle Scholar
  4. Augustine, D.L., 1934, Studies on the subject of prenatal trichinosis, Am. J. Hyg. 29: 115–122.Google Scholar
  5. Backwinkel, K-P., and Themann, H., 1972, Elektronenmikroskopische Untersuchungen über die Pathomorphologie der Trichinellose, Beitr. Pathol. 146: 259–271.PubMedGoogle Scholar
  6. Barriga, O.O., 1978, Reliability of muscle samples to estimate Trichinella infections in the mouse, J. Parasitol. 64: 954–955.PubMedCrossRefGoogle Scholar
  7. Bass, G.K., and Olson, L.J., 1965, Trichinella spiralis in newborn mice: Course of infection and effect on resistance to challenge, J. Parasitol. 51: 640–644.PubMedCrossRefGoogle Scholar
  8. Basten, A., and Beeson, P.B., 1970, Mechanisms of eosinophilia. II. Role of the lymphocyte, J. Exp. Med. 131: 1288–1304.PubMedCrossRefGoogle Scholar
  9. Beckett, E.B., and Boothroyd, B., 1960, The ultrastructure of the “cilia-like” processes in the mid-gut of Trichinella spiralis larvae, in: Proc. Eur. Reg. Conf. on Electron Microscopy, Vol. II, Delft, pp. 938–941Google Scholar
  10. Beckett, E.B., and Boothroyd, B., 1961, Some observations on the fine structure of the mature larva of the nematode Trichinella spiralis, Ann. Trop. Med. Parasitol. 55: 116–124.PubMedGoogle Scholar
  11. Bell, R.D., McGregor, D.D., and Despommier, D.D., 1979, Trichinella spiralis: Mediation of the intestinal component of protective immunity in the rat by multiple phase-specific, antiparasitic responses, Exp. Parasitol. 47: 140–157.PubMedCrossRefGoogle Scholar
  12. Belosevic, M., and Dick, T.A., 1980, Chemical attraction in the genus Trichinella, J. Parasitol. 66: 88–93.PubMedCrossRefGoogle Scholar
  13. Berezantsev, Y.A., 1954, Raccoon dog as a new host of Trichinella, Dokl. Akad. Nauk. SSSR 94: 791.PubMedGoogle Scholar
  14. Berntzen, A.K., 1965, Comparative growth and development of Trichinella spiralis in vitro and in vivo with a redescription of the life-cyle, Exp. Parasitol. 16: 74–106.PubMedCrossRefGoogle Scholar
  15. Bessonov, A.S., Penkova, R.A., Gumenshchickova, V.P., 1976, Trichinella pseudospiralis Garkavi, 1972: Morphological and biological characteristics and host specificity, in: Trichinellosis (C. Kim, ed.), University Press of New England, Hanover, New Hampshire, pp. 79–93.Google Scholar
  16. Bonner, T.P., and Etges, F.J., 1967, Chemically mediated attraction in Trichinella spiralis, Exp. Parasitol. 21: 53–60.PubMedCrossRefGoogle Scholar
  17. Boyd, E.M., and Huston, E.J., 1954, The distribution, longevity and sex ratio of Trichinella spiralis in hamsters following an initial infection, J. Parasitol. 40: 686–690.PubMedCrossRefGoogle Scholar
  18. Bruce, R.G., 1966, The fine structure of the intestine and hind-gut of the larva of Trichinella spiralis, Parasitology 56: 359–365.PubMedCrossRefGoogle Scholar
  19. Bruce, R. G., 1970a, Trichinella spiralis: Fine structure of body wall with special reference to formation and molting of cuticle, Exp. Parasitol. 28: 499–511.PubMedCrossRefGoogle Scholar
  20. Bruce, R.G., 1970b, Structure of the esophagus of the infective juvenile and adult Trichinella spiralis, J. Parasitol. 56: 540–549.PubMedCrossRefGoogle Scholar
  21. Bruce, R.G., 1970c, The structure and composition of the capsule of Trichinella spiralis in host muscle, Parasitology 60: 223–227.PubMedCrossRefGoogle Scholar
  22. Bruce, R.G., 1974, Occurrence of hypodermal gland cells in the bacillary band of Trichinella spiralis during two phases of its life cycle, in: Trichinellosis (C. Kim, ed.), Intext, New York, pp. 43–49.Google Scholar
  23. Brzosko, M.J., and Gancarz, Z., 1969, Immunoelectronmicroscopic studies on antibody binding to the cuticle of Trichinella spiralis larvae, Wiad. Parazytol. 15: 606–617.Google Scholar
  24. Brzosko, W., Gancarz, Z., and Nowoskawski, A., 1965, Immunofluorescence in the serological diagnosis of Trichinella spiralis infection, Med. Doswi. Mikrobiol. 17: 325–332.Google Scholar
  25. Cameron, T.W.M., 1960, Trichinosis in Canada, Wiad. Parazytol. 6: 304–321.Google Scholar
  26. Campbell, C.H., 1955, The antigenic role of the excretion and secretions of Trichinella spiralis in the production of immunity in mice, J. Parasitol. 41: 483–491.PubMedCrossRefGoogle Scholar
  27. Campbell, W.C., 1967, Distribution of Trichinella spiralis in the small intestine of young mice, J. Parasitol. 53: 395–397.PubMedCrossRefGoogle Scholar
  28. Campbell, W.C., and Cuckler, A.C., 1966, Further studies on the effects of thiabendazole on trichinosis in swine, with notes on the biology of the infection, J. Parasitol. 52: 260–279.CrossRefGoogle Scholar
  29. Campbell, W.C., and Yakstis, J.J., 1969, Mating success and fecundity of pairs of Trichinella larvae administered to mice, Wiad. Parazytol. 15: 526–532.PubMedGoogle Scholar
  30. Castro, G. A., and Fairbairn, D., 1969, Carbohydrates and lipids in Trichinella spiralis larvae and their utilization in vitro, J. Parasitol. 55: 51–58.PubMedCrossRefGoogle Scholar
  31. Castro, G.A., Olson, L.J., and Baker, R.D., 1967, Glucose malabsorption and intestinal histopathology in Trichinella spiralis-infected guinea pigs, J. Parasitol. 53: 595–612.PubMedCrossRefGoogle Scholar
  32. Castro, G.A., Johnson, L.R., Copeland, E.M., and Dudrick, S.J., 1974, Development of enteric parasites in parenterally fed rats, Proc. Soc. Exp. Biol. Med. 146: 703–706.PubMedGoogle Scholar
  33. Castro, G.A., Johnson, L.R., Copeland, E.M., Dudrick, S.J., et al., 1976, Course of infection with enteric parasites in hosts shifted from enterai to total parenteral, J. Parasitol. 62: 353–359.PubMedCrossRefGoogle Scholar
  34. Cerfontaine, P., 1895, Contribution a l’étude da la trichinose, Arch. Biol. 13: 125–145.Google Scholar
  35. Chipman, P.B., 1957, The antigenic role of the excretions and secretions of adult Trichinella spiralis in the production of immunity in mice, J. Parasitol. 43: 593–598.PubMedCrossRefGoogle Scholar
  36. Chirasak, K., 1971, Output of larvae and life span of Trichinella spiralis in relation to worm burden and superinfection in the mouse, J. Parasitol. 57: 289–297.CrossRefGoogle Scholar
  37. Chitwood, B.G., 1930, The structure of the esophagus in the Trichuroidea, J. Parasitol. 17: 35–42.CrossRefGoogle Scholar
  38. Chitwood, M.D., and Chitwood, B.G., 1950, An Introduction to Nematology, University Park Press, Baltimore.Google Scholar
  39. Chute, R.M., 1961, Infection of Trichinella spiralis in hibernating hamsters, J. Parasitol. 47: 25–29.PubMedCrossRefGoogle Scholar
  40. Chute, R.M., and Covalt, D.B., 1960, The effect of body temperature on the development of T. spiralis in bats, J. Parasitol. 46: 855–858.PubMedCrossRefGoogle Scholar
  41. Crandall, C.A., and Kozek, W., 1974, Immunogenicity of the stichosome of Trichinella spiralis, in: Trichinellosis (C. Kim, ed.), Intext, New York, pp. 231–238.Google Scholar
  42. Crandall, R.B., 1975, Decreased resistance to Trichinella spiralis in aged mice, J. Parasitol. 63: 566–567.CrossRefGoogle Scholar
  43. Debell, J.T., 1965, A long look at neuromuscular junctions in nematodes, Q. Rev. Biol. 40: 233–251.CrossRefGoogle Scholar
  44. Denham, D.A., 1966, Infections with Trichinella spiralis passing from mother to filial mice pre-and post-natally, J. Helminthol. 40: 291–296.PubMedCrossRefGoogle Scholar
  45. Denham, D.A., 1968, Immunity to Trichinella spiralis. III. The longevity of the intestinal phase of the infection in mice, J. Helminthol. 62: 257–268.CrossRefGoogle Scholar
  46. Denham, D.A., and Martinez, A.R., 1970, Studies with methyridine and Trichinella spiralis. 2. The use of the drug to study the rate of larval production in mice, J. Helminthol. 44: 357–363.PubMedGoogle Scholar
  47. Dennis, D., Despommier, D.D., and Davis, N., 1970, The infectivity of the newborn larva of Trichinella spiralis in the rat, J. Parasitol. 56: 974–977.PubMedCrossRefGoogle Scholar
  48. Despommier, D.D., 1971, Immunogenicity of the newborn larva of Trichinella spiralis, J. Parasitol. 57: 531–535.PubMedCrossRefGoogle Scholar
  49. Despommier, D.D., 1973, A circular thermal migration device for the rapid collection of large numbers of intestinal helminths, J. Parasitol. 59: 933–935.PubMedCrossRefGoogle Scholar
  50. Despommier, D.D., 1974, The stichocyte of Trichinella spiralis during morphogenesis in the small intestine of the rat, in: Trichinellosis (C. Kim, ed.), Intext, New York, pp. 239–254.Google Scholar
  51. Despommier, D., 1975, Adaptive changes in muscle fibers infected with Trichinella spiralis, Am. J. Pathol. 78: 477–496.PubMedGoogle Scholar
  52. Despommier, D., 1976, Musculature. in: Ecological Aspects of Parasitology (C.R. Kennedy, ed.), North-Holland, Amsterdam, pp. 270–285.Google Scholar
  53. Despommier, D.D., 1977, Immunity to Trichinella spiralis, Am. J. Trop. Med. Hyg. 26: 68–75.PubMedGoogle Scholar
  54. Despommier, D.D., and Laccetti, A., 1981, Trichinella spiralis: Partial characterization of antigens isolated by immuno-affinity chromatography from the large-particle fraction of the muscle larva, J. Parasitol. 67: 332–339.PubMedCrossRefGoogle Scholar
  55. Despommier, D.D., and Müller, M., 1970, The stichosome of Trichinella spiralis: Its structure and function, J. Parasitol. 56(Sect. II, Part I), Second Int. Congr. Parasitol., pp. 76–77.Google Scholar
  56. Despommier, D.D., and Müller, M., 1976, The stichosome and its secretion granules in the mature muscle larva of Trichinella spiralis, J. Parasitol. 62: 775–785.PubMedCrossRefGoogle Scholar
  57. Despommier, D.D., and Wostmann, B.S., 1968, Diffusion chambers for inducing immunity to Trichinella spiralis in mice, Exp. Parasitol. 23: 228–233.PubMedCrossRefGoogle Scholar
  58. Despommier, D.D., Kajima, M., and Wostmann, B.S., 1967, Ferritin-conjugated antibody studies on the larva of Trichinella spiralis, J. Parasitol. 53: 618–624.PubMedCrossRefGoogle Scholar
  59. Despommier, D.D., Aron, L., and Turgeon, L., 1975, Trichinella spiralis: Growth of the intracellular (muscle) larva, Exp. Parasitol. 37: 108–116.PubMedCrossRefGoogle Scholar
  60. Despommier, D.D., Campbell, W.C., and Blair, L., 1977, The in vivo and in vitro analysis of immunity to Trichinella spiralis in mice and rats, Parasitology 74: 109–119.PubMedCrossRefGoogle Scholar
  61. Despommier, D., Sukhdeo, M., and Meerovitch, E., 1978, Trichinella spiralis: Site selection by the larva during the enterai phase of the infection in mice, Exp. Parasitol. 44: 209–215.PubMedCrossRefGoogle Scholar
  62. Dick, T.A., and Silver, B.B., 1980, Intestinal distribution of Trichinella spiralis in rats, J. Parasitol. 66: 472–477.CrossRefGoogle Scholar
  63. Doerr, R., and Menzl, E., 1933, Studien über den Mechanismus der Trichinelleninfektion. VIII. Vergleichende Untersuchungen über die Empfanglichkiet der Ratte und des Meerschweinchens für die Infektion per os, Zentralbl. Bakteriol. Parasitenkd. Infektionskr. Hyg. Abt. 1: Orig. 128: 177–188.Google Scholar
  64. Ducas, R., 1921, L’immunité dans la Trichinose, Thesis, Jouve et Cie, Paris, 47 pp.Google Scholar
  65. Dunlap, G.L., and Weller, C.V., 1933, Pathogenesis of trichinous myocarditis, Proc. Soc. Exp. Biol. Med. 30: 1261–1262.Google Scholar
  66. Edney, J.M., Arbogast, F., and Stepp, J., 1953, Productivity in gravid Trichinella spiralis (Owen, 1835) transplanted into laboratory rats, J. Tenn. Acad. Sci. 28: 62–68.Google Scholar
  67. Faaske, E., and Themann, H., 1961, Elektronmicroskopische Befunde an der Muskelfasen nach Trichinbefall, Virchows Arch. Pathol. Anat. 334: 459–474.CrossRefGoogle Scholar
  68. Farris, K.N., and Harley, J.P., 1977, Trichinella spiralis: Alteration of gastrocnemius muscle kinetics in the mouse, Exp. Parasitol. 41: 11–70.CrossRefGoogle Scholar
  69. Ferguson, J.D., and Castro, C.A., 1973, Metabolism of intestinal stages of Trichinella spiralis, Am. J. Physiol. 255: 85–89.Google Scholar
  70. Forrester, A.T., Nelson, G.S., and Sander, G., 1961, The first record of an outbreak of trichinosis in Africa south of the Sahara, Trans. R. Soc. Trop. Med. Hyg. 55: 503–513.PubMedCrossRefGoogle Scholar
  71. Gardiner, C.H., 1976, Habitat and reproductive behavior of Trichinella spiralis, J. Parasitol. 62: 865–870.PubMedCrossRefGoogle Scholar
  72. Gaugusch, Z., 1950, Studies on the infection of poikilothermic animals with T. spiralis, Ann. Univ. Mariae Curie-Sklodowska Vet. Med. 5(Sect. DD): 95–106.Google Scholar
  73. Graham, J.Y., 1897, Beiträge zur Naturgeschichte der Trichina spiralis, Arch. Mikrosk. Anat. 50: 219–275.CrossRefGoogle Scholar
  74. Gursch, O.F., 1949, Intestinal phase of Trichinella spiralis (Owen 1835) Railliet, 1895, J. Parasitol. 35: 19–26.PubMedCrossRefGoogle Scholar
  75. Harley, J.P., and Gallicchico, V., 1971, Trichinella spiralis: Migration of larvae in the rat, Exp. Parasitol. 30: 11–12.PubMedCrossRefGoogle Scholar
  76. Heller, M., 1933, Entwickelt sich die Trichinella spiralis in der Darmlichtung ihres Wirtes?, Z. Parasitenkol. 5: 370–392.CrossRefGoogle Scholar
  77. Hemmert-Halswick, A., and Bugge, G., 1934, Trichinen und Trichinose, Ergeh. Allg. Pathol. 28: 313–392.Google Scholar
  78. Herbst, G., 1851, Beobachtungen über Trichina spiralis in Betreff zu Vebertragung der Ergewudwurmer, Nachr. Georg-August Univ. Konigl. Ges. Wiss. Goettingen 262–264.Google Scholar
  79. Hitcho, P.J., and Thorson, R.E., 1971, Possible molting and maturation controls in Trichinella spiralis, J. Parasitol. 57: 787–793.PubMedCrossRefGoogle Scholar
  80. Hope, W.D., 1969, Fine structure of the somatic muscles of the free-living marine nematode Dentostoma californicum Steiner and Abin 1933 (Leptosomatidae), Proc. Helminthol. Soc. Wash. 36: 10–29.Google Scholar
  81. Hughes, W.L., and Harley, J.P., 1977, Trichinella spiralis: Taxes of first-stage migratory larvae, Exp. Parasitol. 42: 363–373.PubMedCrossRefGoogle Scholar
  82. Humes, A.G., and Akers, R.P., 1952, Vascular changes in the cheek pouch of the golden hamster during infection with Trichinella spiralis larvae, Anat. Rec. 114: 103–113.PubMedCrossRefGoogle Scholar
  83. Jackson, G.J., 1959, Fluorescent antibody studies of Trichinella spiralis infections, J. Infect. Dis. 105: 97–117.PubMedCrossRefGoogle Scholar
  84. James, E.R., and Denham, D.A., 1974, The stage specificity of the immune response to Trichinella spiralis, in: Trichinellosis (C. Kim, ed.), Intext, New York, pp. 345–351.Google Scholar
  85. James, E.R., and Denham, D.A., 1975, Immunity to Trichinella spiralis. VI. The specificity of the immune response stimulated by the intestinal stage, J. Helminthol. 49: 43–47.PubMedCrossRefGoogle Scholar
  86. James, E.R., Maloney, A., and Denham, D.A., 1977, Immunity to Trichinella spiralis. VII. Resistance stimulated by the parenteral stages of the infection, J. Parasitol. 63: 720–723.PubMedCrossRefGoogle Scholar
  87. Janitschke, B., 1962, Untersuchungen an Meerschweinchen über die Wirkung von Promintic und Ruelene auf Larven von Trichinella spiralis und Toxocara canis, Dissertation, Free University, Berlin.Google Scholar
  88. Katz, F.F., 1960, The oral transplantation of intestinal stages of Trichinella spiralis, J. Parasitol. 46: 500–504.PubMedCrossRefGoogle Scholar
  89. Kennedy, M.W., 1978, Kinetics of establishment, distribution and expulsion of the enteral phase of Trichinella spiralis in the NIH strain of mouse, in: Trichinellosis (C. Kim and Z. Pawłowski, eds.), University Press of New England, Hanover, New Hampshire, pp. 193–205.Google Scholar
  90. Kim, C.W., 1961, The cultivation of Trichinella spiralis in vitro, Am. J. Trop. Med. Hyg. 10: 742–747.PubMedGoogle Scholar
  91. Kim, C.W., 1962, Further study on the in vitro cultivation of Trichinella spiralis, Am. J. Trop. Med. Hyg. 11: 491–496.PubMedGoogle Scholar
  92. Kozek, W.J., 1971a, The molting pattern in Trichinella spiralis. I. A light microscope study, J. Parasitol. 57: 1015–1028.PubMedCrossRefGoogle Scholar
  93. Kozek, W.J., 1971b, The molting pattern in Trichinella spiralis. II. An electron microscopy study, J. Parasitol. 57: 1029–1038.PubMedCrossRefGoogle Scholar
  94. Kozek, W.J., 1975, Trichinella spiralis: Morphological characteristics of male and female intestine-infecting larvae, Exp. Parasitol. 37: 380–387.PubMedCrossRefGoogle Scholar
  95. Kozek, W.J., and Crandall, C.A., 1974, Immunogenicity of the stichosome of Trichinella spiralis in mice, in: Trichinellosis (C. Kim, ed.), Intext, New York, pp. 231–237.Google Scholar
  96. Kuitunen-Ekbaum, E., and Webster, D., 1947, Trichinosis in wild rats in Toronto, Can. J. Public Health 38: 76–78.PubMedGoogle Scholar
  97. Larsh, J.E., Jr., and Hendricks, J.R., 1949, The probable explanation for the differences in localization of adult Trichinella spiralis in young and old mice, J. Parasitol. 35: 101–106.PubMedCrossRefGoogle Scholar
  98. Lee, T.D.G., and Wright, K.A., 1978, The morphology of the attachment and probable feeding site of the nematode, Trichuris muris (Shrank 1788) Hall 1916, Can. J. Zool. 56: 1889–1905.PubMedCrossRefGoogle Scholar
  99. Leonard, A.B., and Beahm, E.H., 1941, Studies on the distribution of Trichinella larvae in the albino rat, Trans. Kans. Acad. Sci. 44: 419–433.Google Scholar
  100. Leuckart, R., 1860, Untersuchungen über Trichina spiralis, Winter, Leipzig, 57 pp.Google Scholar
  101. Lightner, L.K., and Ulmer, M.J., 1974, Trichinella spiralis: Effect of environmental temperature on mice, Exp. Parasitol. 35: 262–265.PubMedCrossRefGoogle Scholar
  102. Lison, L., 1936, Histochimie Animale, Gautier-Villars, Paris.Google Scholar
  103. Mackenzie, CD., Preston, P.M., and Ogilvie, B.M., 1978, Immunological properties of the surface of parasitic nematodes, Nature (London) 276: 826–827.CrossRefGoogle Scholar
  104. Maier, D.M., and Zaiman, H., 1966, The development of lysosomes in rat skeletal muscle in trichinosis myositis, J. Histochem. Cytochem. 14: 396–400.CrossRefGoogle Scholar
  105. Manku, S., and Hamilton, R., 1972, The effect of sex and sex hormones on the infection of rats by Trichinella spiralis, Can. J. Zool. 50: 597–602.CrossRefGoogle Scholar
  106. Matoff, K., 1935, Versuche zur Feststellung der Mindestzahl von Muskeltrichinellen, welche zur Invadierung von Mäusen, Ratten, Meerschweinchen, Kaninchen und Hunden erförderlich ist, Tierarztl. Rundsch 41: 466–471.Google Scholar
  107. Matoff, K., 1961, Further studies on muscle trichinellosis produced by infection with intestinal forms, Z. Parasitenkd. 20: 470–476.PubMedCrossRefGoogle Scholar
  108. Matoff, K., 1963, On the transplantation of young intestinal trichinellae, Z. Parasitenkd. 22: 495–513.PubMedCrossRefGoogle Scholar
  109. Mauss, E.A., and Otto, G.F., 1942, The occurrence of Trichinella spiralis larvae in tissues other than skeletal muscles, J. Lab. Clin. Med. 27: 1384–1387.Google Scholar
  110. McCoy, O.R., 1932, Experimental trichiniasis infections in monkeys, Proc. Soc. Exp. Biol. Med. 30: 85–86.Google Scholar
  111. McCoy, O.R., 1936, The development of trichinae in abnormal environments, J. Parasitol. 22: 54–59.CrossRefGoogle Scholar
  112. McCoy, O.R., 1940, Rapid loss of Trichinella larvae fed to immune rats and its bearing on the mechanisms of immunity, Am. J. Hyg. 32: 105–116.Google Scholar
  113. McCue, J.F., and Thorson, R.E., 1965, Host effects on the migration of Nippostrongylus brasiliensis in a thermal gradient, J. Parasitol. 51: 414–417.PubMedCrossRefGoogle Scholar
  114. McLaren, D.L., 1976, Nematode sense organs, in: Advances in Parasitology, Vol. 14 (B. Dawes, ed.), Academic Press, New York, pp. 195–265.Google Scholar
  115. Meerovitch, E., 1962, In vitro development of Trichinella spiralis larvae, J. Parasitol. (Suppl.) 48: 34.Google Scholar
  116. Meerovitch, E., 1965a, Studies on the in vitro axenic development of Trichinella spiralis. I. Basic culture techniques, pattern of development and the effects of the gaseous phase, Can. J. Zool. 43: 69–79.PubMedCrossRefGoogle Scholar
  117. Meerovitch, E., 1965b, Studies on the in vitro axenic development of Trichinella spiralis. II. Preliminary experiments on the effects of farnesol, cholesterol, and an insect extract, Can. J. Zool. 43: 81–85.CrossRefGoogle Scholar
  118. Mikhail, E.G., and Soliman, A.A., 1978, Productivity of one pair of Trichinella spiralis larvae administered to rats, J. Egypt. Soc. Parasitol. 8: 219–226.Google Scholar
  119. Mills, C.K., and Kent, N.H., 1965, Excretions and secretions of Trichinella spiralis and their role in immunity, Exp. Parasitol. 16: 300–310.PubMedCrossRefGoogle Scholar
  120. Most, H., and Abeles, M.M., 1937, Trichinosis involving the nervous system: A clinical and neuropathologic review, with report of two cases, Arch. Neurol. Psychiatry 37: 589–616.Google Scholar
  121. Nelson, G.S., and Forrester, A.T.T., 1962, Trichinosis in Kenya, Wiad. Parazytol. 8: 17–28.PubMedGoogle Scholar
  122. Nelson, G.S., Blackie, E.J., and Mukundi, S., 1966, Comparative studies of geographical strains of Trichinella spiralis, Trans. R. Soc. Trop. Med. Hyg. 60: 471–480.PubMedCrossRefGoogle Scholar
  123. Nolf, L.O., 1937, The transplantation of gravid Trichinella spiralis, J. Parasitol. 23: 574.Google Scholar
  124. Novoselska, L.S., 1974, Common features between cuticle antigens of Trichinella larvae and hen, dog, and guinea pig muscles, C. R. Acad. Bulg. Sci. 27: 12–21.Google Scholar
  125. Oliver, V.L., 1961, The distribution of trichinae larvae in the muscles of experimentally infected rats, Dissertation, University of Alabama, 56 pp.Google Scholar
  126. Olsen, B.S., Villella, J.B., and Gould, S.E., 1964, Distribution of Trichinella spiralis in muscles of experimentally infected swine, J. Parasitol. 50: 489–495.PubMedCrossRefGoogle Scholar
  127. Pagenstecher, H.A., 1865, Die Trichinen, Engelmanns, Leipzig, 116 pp.Google Scholar
  128. Pawłowski, Z., 1967a, Hormones of the adrenal cortex in experimental trichinellosis of rats. I. Effect of prednisone on the number of mature and larval forms, Acta Parasitol. Pol. 14: 163–172.Google Scholar
  129. Pawłowski, Z., 1967b, Adrenal cortex hormones in intestinal trichinellosis. II. Effect of adrenalectomy, desoxycorticosterone and glucocorticoids on the course of trichinellosis in rats, Acta Parasitol. Pol. 15: 157–170.Google Scholar
  130. Pawłowski, Z., 1967c, Adrenal cortex hormones in intestinal trichinellosis. III. Effects of adrenalectomy and hydrocortisone, insulin, alloxan and glucose treatment on elimination of Trichinella spiralis adult in hooded rats, Acta Parasitol. Pol. 15: 179–189.Google Scholar
  131. Penkova, R.A., and Romanenko, L.N., 1973, Studies on Trichinella chromosomes, Tr. Vses. Inst. Gel’mintol. K.I. Skryabina 20: 133–142.Google Scholar
  132. Perrudet-Badoux, A., and Binaghi, R.A., 1978, Immunity against newborn Trichinella spiralis larvae in previously infected mice, J. Parasitol. 64: 187–189.PubMedCrossRefGoogle Scholar
  133. Perrudet-Badoux, A., Binaghi, R.A., and Biozzi, G., 1975, Trichinella infestation in mice genetically selected for high and low antibody production, Immunology 29: 387–390.PubMedGoogle Scholar
  134. Perrudet-Bodoux, A., Binaghi, R.A., and Bonssac-Aron, Y., 1978, Trichinella spiralis infection in mice: Mechanism of the resistance in animals genetically selected for high and low antibody production, Immunology 35: 519–522.Google Scholar
  135. Podhajecky, K., 1962, Localization of intestinal trichinellae in the small intestine of mice in their intestinal phase, Wiad. Parazytol. 8: 633–636.PubMedGoogle Scholar
  136. Podhajecky, K., 1963, Male-female ratio of Trichinella spiralis in various phases of infection in white mice, Biologia 18: 75–78.PubMedGoogle Scholar
  137. Przyjalkowski, Z., 1968, Effect of intestinal flora and of a monoculture of E. coli on the development of intestinal and muscular Trichinella spiralis in gnotobiotic mice, Bull. Acad. Pol. Sci. Cl. 2 16: 433–437.Google Scholar
  138. Przyjalkowski, Z.W., and Golinska, Z., 1978, Host response to intestinal infection with Trichinella spiralis and Trichinella pseudospiralis in germ-free and conventional mice, in: Trichinellosis (C. Kim and Z.S. Pawłowski, eds.), University Press of New England, Hanover, New Hampshire, pp. 141–150.Google Scholar
  139. Przyjalkowski, Z., and Wescott, R., 1969, Trichinella spiralis: Establishment in gnotobiotic mice infected by Bacillus mesentericus, B. subtilis, and Pseudomonas aeruginosa, Exp. Parasitol. 25: 8–12.PubMedCrossRefGoogle Scholar
  140. Purkerson, M., and Despommier, D.D., 1974, Fine structure of the muscle phase of Trichinella spiralis in the mouse, in: Trichinellosis (C. Kim, ed.), Intext, New York, pp. 7–23.Google Scholar
  141. Ramisz, A., 1965, Studies on the nervous system of nematodes by means of histochemical method for active acetycholinesterase. I. Trichinella spiralis and Syphacia abvelata. Acta Parasitol. Pol. 13: 205–214.Google Scholar
  142. Rappaport, I., 1943, A comparison of three strains of Trichinella spiralis. II. Longevity and sex ratios of adults in the intestine and rapidity of larval development in the musculature, Am. J. Trop. Med. Hyg. 23: 351–362.Google Scholar
  143. Rausch, R.L., 1962, Trichinellosis in the Arctic. in: Trichinellosis (Z. Kozar, ed.), Pol. Sci. Publ., Warsaw, pp. 80–86.Google Scholar
  144. Ribas-Mujal, D., and Rivera-Pomar, J.M., 1968, Biological significance of the early structural alterations in skeletal muscle fibers infected by Trichinella spiralis, Virchows Arch. A 345: 154–168.CrossRefGoogle Scholar
  145. Richels, I., 1955, Histologische Studien zu den Problemen der Zellkonstanz: Untersuchungen zur Mikroskopischen Anatomie im Lebenszyklus von Trichinella spiralis, Zentralbl. Bakteriol. 163: 46–84.Google Scholar
  146. Ritterson, A.L., 1959, Innate resistance of species of hamsters to Trichinella spiralis and its reversal by cortisone, J. Infect. Dis. 105: 253–266.PubMedCrossRefGoogle Scholar
  147. Ritterson, A.L., 1966, Nature of the cyst of Trichinella spiralis, J. Parasitol. 52: 157–161.PubMedCrossRefGoogle Scholar
  148. Rivera-Ortiz, C.I., and Nussenzweig, R., 1976, Trichinella spiralis: Anaphylactic antibody formation and susceptibility in strains of inbred mice, Exp. Parasitol. 39: 7–17.PubMedCrossRefGoogle Scholar
  149. Roth, H., 1938, On the localization of adult trichinae in the intestine, J. Parasitol. 24: 225–231.CrossRefGoogle Scholar
  150. Roth, H., 1939, Experimental studies on the course of trichina infection in guinea pigs. II. Natural susceptibility of the guinea pig to experimental trichina infection, Am. J. Hyg. 29:(Sect. D): 89–104.Google Scholar
  151. Ruitenberg, E.J., and Steerenberg, P.A., 1976, Immunogenicity of the parenteral stages of Trichinella spiralis, J. Parasitol. 62: 164–166.PubMedCrossRefGoogle Scholar
  152. Ruitenberg, E.J., Elgersma, A., Kruizinga, W., et al. 1977, Trichinella spiralis in congenitally athymic (nude) mice: Parasitological, serological and haematological studies with observations on intestinal pathology, Immunology 33: 581–587.PubMedGoogle Scholar
  153. Sakamoto, T., 1979, Development and behavior of adult and larval Trichinella cultured in vitro, Mem. Fac. Agric. Kagoshima Univ. 15(24): 107–114.Google Scholar
  154. Saowakontha, S., 1975, The relationship between protein-calorie malnutrition and trichinosis. II. Immunological response in rats fed low and high protein diets, Southeast Asian J. Trop. Med. Public Health 6: 79–81.PubMedGoogle Scholar
  155. Sawitz, W., 1939, Trichinella spiralis: Incidence of infection in man, dogs and cats in the New Orleans area as determined in postmortem examinations, Arch. Pathol. 28: 11–21.Google Scholar
  156. Schoop, G., Lieb, W.A., and Lamina, J., 1961, Die Parasiten des Auges: Tierexperimentelle Untersuchungen über die Trichinose des Auges, Klin. Monatsbl. Augenheilkd. 139: 433–465.Google Scholar
  157. Schope, M., 1949, Encephalitis bei der Trichinose mit Nachweis einer Trichinella in Gehirm, Arch. Psychiatr. Nervenkr. 181: 603–610.CrossRefGoogle Scholar
  158. Schwartz, B., 1938, Trichinosis in swine and its relationship to public health, J. Am. Vet. Med. Assoc. 92: 317–337.Google Scholar
  159. Shanta, C.S., and Meerovitch, E., 1967, The life cycle of Trichinella spiralis. I. The intestinal phase of development, Can. J. Zool. 45: 1255–1260.PubMedCrossRefGoogle Scholar
  160. Smirnov, G.G., 1963, Natural modality of trichinellosis in the Arctic, Ter. Arkh. 42: 338–344.Google Scholar
  161. Stannard, J.N., McCoy, O.R., and Latchford, W.B., 1938, Studies on the metabolism of Trichinella spiralis larvae, Am. J. Hyg. 27: 666–682.Google Scholar
  162. Staubli, C., 1905, Klinische und experimentelle Untersuchungen über Trichinosis, Verh. Kongress. Med. (Wiesbaden) 22: 353–362.Google Scholar
  163. Stefanski, W., and Przyjalkowski, Z., 1964, The influence of certain bacteria on the establishment of trichinae in the digestive tract of the mouse, Bull. Acad. Vet. Fr. 37: 131–135.Google Scholar
  164. Stefanski, W., and Kozar, M., 1969, Degree of resistance of some mouse strains to Trichinella spiralis infections, Wiad. Parazytol. 15: 571–575.PubMedGoogle Scholar
  165. Stewart, G.L., 1973, Studies on chemical pathology in trichinosis, Thesis, Rice University, Houston.Google Scholar
  166. Stewart, G., 1978, Trichinella spiralis: Alterations of blood chemistry in the mouse, Exp. Parasitol. 45: 287–297.PubMedCrossRefGoogle Scholar
  167. Stewart, G.L., and Charniga, L.M., 1980, Distribution of Trichinella spiralis in muscles of the mouse, J. Parasitol. 66: 688–689.PubMedCrossRefGoogle Scholar
  168. Stewart, G.L., and Read, C.P., 1972, Ribonucleic acid metabolism in mouse trichinosis, J. Parasitol. 58: 252–256.PubMedCrossRefGoogle Scholar
  169. Stewart, G.L., and Read, C.P., 1973a, Desoxyribonucleic acid metabolism in mouse trichinosis, J. Parasitol. 59: 164–167.Google Scholar
  170. Stewart, G.L., and Read, C.P., 1973b, Changes in RNA in mouse trichinosis, J. Parasitol. 59: 997–1005.PubMedCrossRefGoogle Scholar
  171. Stewart, G.L., and Read, C.P., 1974, Studies on biochemical changes in trichinosis. I. Changes in myoglobin, free creatine, phosphocreatine, and two protein fractions in mouse muscle, J. Parasitol. 60: 996–1000.PubMedCrossRefGoogle Scholar
  172. Stewart, G.L., Krama, G.W., Reddington, J.J., and Hamilton, M., 1980, Studies on in vitro larvaposition by adult Trichinella spiralis, J. Parasitol. 66: 94–99.PubMedCrossRefGoogle Scholar
  173. Stoner, R.D., and Hankes, L.V., 1955, Incorporation of C14-labelled amino acids by Trichinella spiralis larvae, Exp. Parasitol. 4: 435–444.PubMedCrossRefGoogle Scholar
  174. Sukhdeo, M.V.K., and Croll, N.A., 1981, The location of parasites within their hosts: Factors affecting longitudinal distribution of Trichinella spiralis in the small intestine, Int. J. Parasitol. 11: 163–168.PubMedCrossRefGoogle Scholar
  175. Sukhdeo, M.V.K., and Meerovitch, E., 1977, Comparison of three geographical isolates of Trichmella, Can. J. Zool. 55: 2060–2064.PubMedCrossRefGoogle Scholar
  176. Sulzer, A.J., 1965, Indirect fluorescent antibody tests for parasitic diseases. I. Preparation of a stable antigen from larvae of Trichinella spiralis, J. Parasitol. 56: 717–721.CrossRefGoogle Scholar
  177. Tanner, C.E., 1968, Relationship between infecting dose, muscle parasitism, and antibody response in experimental trichinosis in rabbits, J. Parasitol. 54: 98–107.PubMedCrossRefGoogle Scholar
  178. Tanner, C.E., 1978, The susceptibility to Trichinella spiralis of inbred lines of mice differing at the H-2 histocompatibility locus, J. Parasitol. 64: 956–957.PubMedCrossRefGoogle Scholar
  179. Tarakanov, V.I., 1963, The in vitro cultivation of Trichinella spiralis, the agent of trichinellosis, in: Gelminty Tcheloveka, Zhivatnykh, i Rastenii i Borba s Nimi, Moscow, pp. 78–82.Google Scholar
  180. Tarakanov, V.I., 1964, The culture of Trichinella spiralis larvae up to the sexually mature stage in artificial nutrient media, Veterinariya (Moscow) 3: 43–47.Google Scholar
  181. Tarakanov, V.I., 1970, The influence of artificial nutrient media on the in vitro development of Trichinella larvae, Tr. Vses. Inst. Gel’mintol. imeni K.I. Skryabina 16: 249–252.Google Scholar
  182. Tarakanov, V.I., and Krasnova, L.L., 1971, The in vitro cultivation of decapsulated Trichinella spiralis larvae in a system of constant flow nutrient medium, Tr. Vses. Inst. Gel’mintol. K.I. Skryabina 17: 229–231.Google Scholar
  183. Teppema, J.S., Robinson, J.E., and Ruitenberg, E.J., 1973, Ultrastructural aspects of capsule formation in Trichinella spiralis infections in rats, Parasitology 66: 291–296.PubMedCrossRefGoogle Scholar
  184. Thomas, H., 1965, Beitrage zur Biologie und mikroskopischen Anatomie von Trichinella spiralis Owen, 1835, Z. Tropenmed. Parasitol. 16: 148–180.PubMedGoogle Scholar
  185. Thornbury, F.J., 1897, The pathology of trichinosis: Original observations, Univ. Med. Mag. 10: 64–79.Google Scholar
  186. Van Cott, J.M., and Lintz, W., 1914, Trichinosis, J. Am. Med. Assoc. 62: 680–684.Google Scholar
  187. Van Someren, V.D., 1939, On the presence of a buccal stylet in adult Trichinella, and the mode of feeding of the adults, J. Helminthol. 17: 83–92.CrossRefGoogle Scholar
  188. Villella, J.B., 1958, Observations on the time and number of molts in the intestinal phase of Trichinella spiralis, J. Parasitol. 44: 41.CrossRefGoogle Scholar
  189. Villella, J.B., 1966, Morphologic criteria for distinguishing the sex of Trichinella spiralis larvae from muscle, J. Parasitol. 52: 908–910.PubMedCrossRefGoogle Scholar
  190. Villella, J.B., 1970, Life cycle and morphology, in: Trichinosis in Man and Animals (S.E. Gould, ed.), Charles C. Thomas, Springfield, Illinois, pp. 19–60.Google Scholar
  191. Virchow, R., 1859, Recherches sur le development du Trichina spiralis, C. R. Acad. Sci. 49: 660–662.Google Scholar
  192. Von Brand, T., Weinstein, P.P., Mellman, B., and Weinbach, E.C., 1952, Observations on the metabolism of bacteria-free larvae of Trichinella spiralis, Exp. Parasitol. 1: 245–255.CrossRefGoogle Scholar
  193. Wakelin, D., 1980, Genetic control of immunity to parasites. Infection with Trichinella spiralis in inbred and congenic mice showing rapid and slow responses to infection, Parasite Immunol. 3: 85–98.CrossRefGoogle Scholar
  194. Wassom, D.L., David, C.S., and Gleich, G.J., 1979, Genes within the major histocompatibility complex influence susceptibility to Trichinella spiralis in the mouse, Immunogenetics 9: 491–496.CrossRefGoogle Scholar
  195. Weiler, T.H., 1943, The development of the larvae of Trichinella spiralis in roller tube tissue culture, Am. J. Pathol. 19: 502–515.Google Scholar
  196. Wolffhugel, K., 1938, Wieviel eingekapselte Trichinen (Trichinella spiralis) erzeugt ein Muttertier?, Z. Fleisch-Milchhyg. 48: 301–302.Google Scholar
  197. Wright, K., 1979, Trichinella spiralis: An intracellular parasite in the intestinal phase, J. Parasitol. 65: 441–445.PubMedCrossRefGoogle Scholar
  198. Wright, K.A., and Hope, W.D., 1968, Elaborations of the cuticle of Acanthonchus duplicatus Weiser, 1959 (Nematoda: Cyatholaimidae), as revealed by light and electron microscopy, Can. J. Zool. 46: 1005–1011.CrossRefGoogle Scholar
  199. Wu, L.Y., 1955a, Studies on Trichinella spiralis. I. Male and female reproductive system, J. Parasitol. 41: 40–47.CrossRefGoogle Scholar
  200. Wu, L.Y., 1955b, The development of the stichosome and associated structures in Trichinella spiralis, Can. J. Zool. 33: 440–466.CrossRefGoogle Scholar
  201. Wu, L.Y., and Kingscote, A.A., 1957, Studies on Trichinella spiralis. II. Times of final molts, spermatozoa formation, ovulation, and insemination, Can. J. Zool. 35: 207–211.CrossRefGoogle Scholar
  202. Zimmerman, E.A., Hsu, K.C., Robinson, A.G., Carmel, P.W., Franz, A.G., and Tannen-baum, M., 1973, Studies of neurophysin secreting neurons with immunoperoxidase techniques employing antibody to bovine neurophysin. I. Light microscopic findings in monkeys and bovine tissues, Endocrinology 92: 931–940.PubMedCrossRefGoogle Scholar
  203. Zimmermann, W.J., Hubbard, E.D., Schwarte, L.H., and Biester, H.E., 1962, Trichinella spiralis in Iowa wildlife during the years 1953 to 1961, J. Parasitol. 48: 429–432.CrossRefGoogle Scholar
  204. Zuckerman, B.M., (ed.), 1980, Nematodes as Biological Models, Vol. II, Academic Press, New York.Google Scholar

Copyright information

© Plenum Press, New York 1983

Authors and Affiliations

  • Dickson D. Despommier
    • 1
  1. 1.Division of Tropical MedicineSchool of Public Health, Columbia UniversityNew YorkUSA

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