Morphological Aspects of Brain Damage in Aging

  • Stephen W. Scheff
  • Kevin Anderson
  • Steven T. DeKosky
Chapter

Abstract

The field of neurobiology has recently witnessed a surge of research aimed at studying and evaluating neural growth following various types of damage in the mammalian central nervous system (CNS). This research has taken on a very intriguing atmosphere since it has been suggested that this growth might serve as a basis for the recovery or restitution of function following damage. Conversely, one possibility must be recognized that aberrant neural circuitry formed as a result of remodeling may be functionally deleterious. Anomalous growth may thus be in part responsible for altered behavioral responses seen within aging. Interest in this area of research is further enhanced when one considers that this reactive growth process takes place not only in the developing nervous system but in the mature adult CNS.

Keywords

Dentate Gyrus Entorhinal Cortex Molecular Layer Brain Damage Granule Cell Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Stephen W. Scheff
    • 1
  • Kevin Anderson
    • 2
  • Steven T. DeKosky
    • 3
    • 4
    • 5
  1. 1.Departments of Anatomy and NeurologyUniversity of Kentucky College of MedicineLexingtonUSA
  2. 2.Department of AnatomyUniversity of Kentucky College of MedicineLexingtonUSA
  3. 3.Department of NeurologyLexington Veterans AdministrationUSA
  4. 4.University of Kentucky Medical CentersUSA
  5. 5.Sanders-Brown Research Center on AgingLexingtonUSA

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