Management of Nasopharyngeal Carcinoma

  • Andrew T. Huang
  • Ian R. Crocker
  • Samuel R. Fisher
  • Mary Jane Wallman
Part of the Developments in Medical Virology book series (DIMV, volume 1)

Abstract

Nasopharyngeal carcinoma is rare in most countries (incidence rate of less than 1 per 100,000) but is a major health problem in some regions (incidence rate as high as 5.8 per 100,000 with a mortality rate of 2.6 per 100,000 reported in 1981 from Taiwan). A search for etiologic factors and development of specific methods of eradication of this cancer remain the focus of investigation by many workers in the field and is the subject of this Symposium. Equally necessary, however, are continued efforts to identify early cases through serologic and cytologic screening, and the development of more effective therapeutic modalities for all stages of illness. The current survival rate of 30–60% reported from various regions of the world is a phase of clinical development which warrants further improvement.

Keywords

Nasal Cavity Nasopharyngeal Carcinoma Radiation Therapy Oncology Group Cranial Nerve Palsy Nasopharyngeal Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Connors, J.M., Andiman, W.A., Merigan, T.C., Treatment of nasopharyngeal carcinoma with interferon:Epstein-Barr virus serology and clinical results of a pilot study. Proc. Amer. Soc. Clin. Oncol, abstract C-771 (1982).Google Scholar
  2. Cooper, J.S., Del Rowe, J., and Newell, J., Regional stage IV carcinoma of the nasopharynx treated by aggressive radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 9: 1737–1745 (1983).PubMedGoogle Scholar
  3. Dharmalingam, S.K., Singh, P., Tan, M.K., Singaram, S.P., and Prasa, U., Cyclophosphamide, vincristine, methotrexate, and adriamycin in untreated nasopharyngeal carcinoma; a report from Malaysian trial on chemotherapy in nasopharyngeal carcinoma. In: U. Prasad, D.V. Ablashi, P.H. Levine, and G.R Pearson (ed.), Nasopharyngeal Carcinoma, Current Concepts, p. 402 (1983).Google Scholar
  4. Fletcher, G.H., and Million, R.R., Malignant tumors of the nasopharynx. Am. J. of Roentgenol Radium Ther. Nucl. Med. 93: 44–55 (1965).Google Scholar
  5. Fu, K.K., Newman, H., and Phillips, T.L., Treatment of locally recurrent carcinoma of the nasopharynx. Radiology 117: 425–431 (1975).PubMedGoogle Scholar
  6. Galligioni, E., Carbone, A., Tirelli, U., Veronesi, A., Trovo, M.G., Donatella, M.M., Crivellari, D., Roncadin, M., Frustaci, S., Tumdo, S., and Grigoletto, E., Combined chemo therapy with doxorubicin, bleomycin, vinblastine, dacarbazine and radiotherapy for advanced lymphoepithelioma. Cancer Treatment Reports 66: 1207–1209 (1982).PubMedGoogle Scholar
  7. Goepfert, H., Moran, M.E., and Lindberg, R.D., Chemotherapy of advanced nasopharyngeal carcinoma. Proc. Amer. Clin. Oncol. 22: 401 (abstract) (1981).Google Scholar
  8. Ho, J.H.C., An epidemiologic and clinical study of naso-pharyngeal cancer. Int. J. Radiat. Oncol. Biol. Phys. 4: 183–198 (1978).CrossRefGoogle Scholar
  9. Hoppe, R.T., Gothenet, D.R., and Bagshaw, M.A., Carcinoma of the nasopharynx; eighteen years experience with mega- voltage radiation therapy. Cancer 37: 2605–2612 (1976).PubMedCrossRefGoogle Scholar
  10. Huang, A.T., Cole, R.B., and Jelovsek, S.B., Adjuvant treatment of nasopharyngeal carcinoma. In: Nasopharyngeal Carcinoma, Current Concepts. University of Malaya Press, Kuala Lumpur, p. 397–401 (1983).Google Scholar
  11. Huang, S.C., Nasopharyngeal cancer; a review of 1,605 pa-tients treated radically with cobalt 60. Int. J. Radiat. Oncol. Biol. Phys. 6: 401–407 (1980).PubMedCrossRefGoogle Scholar
  12. Hsu, M.M., and Tu, S.M., Nasopharyngeal carcinoma in Taiwan. Cancer 52: 361–368 (1983).Google Scholar
  13. Jenkin, R.D.T., Anderson, J.R., Jereb, B., Thompson, J.C., Pyesmany, A., Wara, W.M., and Hammond. D., Nasopharyngeal carcinoma - a retrospective review of patients less than 30 years of age. Cancer 47: 360–366 (1981).PubMedCrossRefGoogle Scholar
  14. Lederman, M., Cancer of the nasopharynx. Charles C. Thomas (1961).Google Scholar
  15. Marcial, V.A., Hanley, J.A., Chang, C., Davis, L.W., and Moscol, J.A., Split-course radiation therapy of carcinoma of the nasopharynx; results of a national collaborative clinical trial of the radiation therapy oncology group. Int. J. Radiat. Oncol. Biol. Phys. 6: 409–414 (1980).PubMedCrossRefGoogle Scholar
  16. Marks, J.E., Bedwineck, J.M., Lee, F., Purdy, J.A:, and Perez, C.A., Dose-response analysis for nasopharyngeal carcinoma. Cancer 50: 1042–1050 (1982).PubMedCrossRefGoogle Scholar
  17. McNeese, M.D., and Fletcher, G.H., Retreatment of recurrent nasopharyngeal carcinoma. Radiology 138: 191–193 (1981).PubMedGoogle Scholar
  18. Meyer, J.E., and Huang, C.C., Carcinoma of the nasopharynx. Radiology 100: 385–388 (1971).PubMedGoogle Scholar
  19. Million, R.R., and Cassisi, N.J., Management of head and neck cancer. J.B. Lippincott (1984).Google Scholar
  20. Moench, H.C., Phillips, T.L., Carcinoma of the nasopharynx: review of 146 patients with emphasis on radiation dose and time factors. Am. J. Surg. 124: 515–518 (1972).PubMedCrossRefGoogle Scholar
  21. Treuner, J., Niethammer, D., Dannecker, G., Jobke, A., Aldenhoff, P., Kremens, B., Nessler, G., and Bommer, H., Treatment of nasopharyngeal carcinoma in children with fibroblast interferon. In: E. Grundmann, G.R.F. Krueger, and D.V. Ablashi (ed.), Nasopharyngeal Carcinoma: Cancer Campaign, Vol 5, pp 309–316, Gustav Fischer Verlag, Stuttgart, New York (1981).Google Scholar
  22. Wang, C.C., Radiation therapy for head and neck neoplasms. John Wright (1983).Google Scholar
  23. Yan, J.H., Hu, Y.H., and Gu, X.Z., Radiation therapy of re-current nasopharyngeal carcinoma; report on 219 patients. Acta Radiol. (Oncol.) 22: 23–28 (1983).CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1985

Authors and Affiliations

  • Andrew T. Huang
  • Ian R. Crocker
    • 1
  • Samuel R. Fisher
    • 1
  • Mary Jane Wallman
    • 1
  1. 1.Depts. of Radiology, Surgery and MedicineDuke University Medical CenterDurhamUSA

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