Radioimmunoassay of Eicosanoids Associated with Tumor Growth

  • Lawrence Levine
Chapter
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 1)

Abstract

Although prostaglandin production has been associated with neoplasia, a causal relationship has never been demonstrated. Most mammalian cells have the enzymes that metabolize arachidonic acid, hut the capacity to generate the thromboxanes, prostacyclins, the various prostaglandins, mono- and dihydroxyfatty acids and the peptide-containing leukotrienes from endogenous substrate varies among the cells (1–7). The relative levels of these arachidonic acid metabolites produced endogenously (the cell’s arachidonic acid metabolite profile) also can vary with the cell’s state of differentiation and nutritional history. Examples of how 1) genetic specification (although it should be realized that postreplicative events also are important), 2) differentiation, and 3) nutrition can affect these profiles are given in Table 1, and Fig. 1 and Fig. 2, respectively.

Keywords

High Performance Liquid Chromatography Arachidonic Acid Arachidonic Acid Metabolism Arachidonic Acid Metabolite Peripheral Plasma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Martinus Nijhoff Publishing, Boston 1985

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  • Lawrence Levine

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