Glomerular Permselectivity

  • Barry M. Brenner
  • Lance D. Dworkin
Chapter

Abstract

The process of glomerular filtration results in the separation of approximately one-fifth to one-third of the plasma entering the glomeruli of each kidney into a solution that has the characteristics of a nearly ideal ultrafiltrate. This high rate of fluid filtration is driven by the hydraulic force created by the pumping action of the heart. However, despite the extremely low resistance of this capillary wall to the flux of water, this same structure normally impedes the filtration of circulating macromolecules (substances with molecular weights of several thousand or more), so that the concentrations of all but the smallest plasma proteins in the glomerular ultrafiltrate are exceedingly small.

Keywords

Glomerular Basement Membrane Dextran Sulfate Glomerular Capillary Wall Glomerular Permeability Molecular Radius 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Barry M. Brenner
    • 1
    • 2
  • Lance D. Dworkin
    • 3
  1. 1.Laboratory of Kidney and Electrolyte PhysiologyDepartment of Medicine, Harvard Medical SchoolUSA
  2. 2.Renal DivisionBrigham & Women’s HospitalBostonUSA
  3. 3.Department of MedicineNew York University Medical CenterNew YorkUSA

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