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Dietary Carcinogens and Anticarcinogens: Oxygen Radicals and Degenerative Diseases

  • Bruce N. Ames
Part of the Advances in Risk Analysis book series (AEMB, volume 220)

Summary

The human diet contains a great variety of natural mutagens and carcinogens, as well as many natural antimutagens and anticarcinogens. Many of these mutagens and carcinogens may act through the generation of oxygen radicals. Oxygen radicals may also play a major role as endogenous initiators of degenerative processes, such as DNA damage and mutation (and promotion), that may be related to cancer, heart disease, and aging. Dietary intake of natural antioxidants could be an important aspect of the body’s defense mechanism against these agents. Many antioxidants are being identified as anticarcinogens. Characterizing and optimizing such defense systems may be an important part of a strategy of minimizing cancer and other age-related diseases.

Keywords

Uric Acid Oxygen Radical Trans Fatty Acid Human Diet Plant Toxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    R. Doll and R. Peto, J. Natl. Cancer Inst. 66:1192 (1981).Google Scholar
  2. 2.
    R Peto and M. Schneiderman, eds., Banbury Report 9. Quantification of Occupational Cancer, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (1981).Google Scholar
  3. 3.
    Cancer Facts and Figures, 1983, American Cancer Society, New York (1982).Google Scholar
  4. 4.
    National Research Council, Diet, Nutrition and Cancer, National Academy Press, Washington, DC (1982).Google Scholar
  5. 5.
    E. C. Miller, J. A. Miller, I. Hirono, T. Sugimura, S. Takayama, eds., Naturally Occurring Carcinogens-Mutagens and Modulators of Carcinogensis, Japan Scientific Societies Press and University Park Press, Tokyo and Baltimore (1979)Google Scholar
  6. E.C. Miller, et al. Cancer Res. 43:1124 (1983)Google Scholar
  7. C. Ioannides, M. Delaforge, D. V. Parke, Food Cosmet. Toxicol. 19:657 (1981).Google Scholar
  8. 6.
    G. J. Kapadia, ed., Oncology Overview on Naturally Occuring Dietary Carcinogenss f Plant Origin, International Cancer Research Data Bank Program, National Cancer Institute, Bethesda, Maryland (1982).Google Scholar
  9. 7.
    A.M. Clark, in Environmental Mutagenesis, Carcinogenesis, and Plant Biology, E. J. Klekowski, Jr., ed., Praeger, New York (1982), vol. 1, pp 97–132.Google Scholar
  10. 8.
    A. M Pamukcu, S. Yalciner, J. F. Hatcher, G.T. Bryan, Cancer Res. 40:3468 (1980)Google Scholar
  11. J. F. Hatcher, A. M. Pamukcu, E. Erturk, G. T. Bryan, Fed. Proc. Fed. Am. Soc. Exp. Biol. 42:786 (1983).Google Scholar
  12. 9.
    H.F. Stich. M. P. Rosin, C. H. Wu, W. D. Powrie, Mutat. Res. 90:201 (1981)Google Scholar
  13. A. A. Avery′yanov, Biokhimiya 46:256 (1981)Google Scholar
  14. A. F. Hanham, B. P. Dunn, H. F. Stich, Mutat. Res. 116:333 (1983).Google Scholar
  15. 10.
    K. H. Pegel, Chem. Eng. News 59:4 (20 July 1981).Google Scholar
  16. 11.
    L. K. T. Lam, V. L. Sparnins, L. W.. Wattenberg, Cancer Res. 42:1193 (1982).Google Scholar
  17. 12.
    S. J. Jadhav, R. P. Sharma, D. K. Salunke, CRC Crit. Rev. Toxicol, 9:21 (1981).Google Scholar
  18. 13.
    R. L. Hall, Nutr. Cancer 1 (No. 2):27 (1979).Google Scholar
  19. 14.
    H. W. Moore and R. Czerniak, Med. Res. Rev. 1:249 (1981).Google Scholar
  20. 15.
    I. Hirono, CRC Crit. Rev. Toxicol. 8:235 (1981).Google Scholar
  21. 16.
    J. P. Brown, Mutat. Res. 75:243 (1980).Google Scholar
  22. 17.
    M. J. Ashwood-Smith and G. A. Poulton, ibid. 85:389 (1981).Google Scholar
  23. 18.
    A. Ya. Potapenko, M.: V. Moshnin, A. A. Krasnovsky, Jr., V. L. Sukhorukov, Z. Naturforsch. 37:70 (1982).Google Scholar
  24. 19.
    G. W. Ivie, D. L. Holt, M. C. Ivey, Science 213:909 (1981)Google Scholar
  25. R. C. Beier and E. H. Oertli, Phytochemistry, in pressGoogle Scholar
  26. R. C. Beier, G. W. Ivie, E. H. Oertli, in “Xenobiotics in Foods and Feeds,” ACS Symp. Ser., in pressGoogle Scholar
  27. R. C. Beier, D. L. Holt, Food Chem. Toxicol. 21:163 (1983)Google Scholar
  28. 20.
    G. Tamura, C. Gold, A. Ferro-Luzzi, B. N. Ames, Proc. Natl. Acad. Sci. U.S.A. 77:4961 (1980).Google Scholar
  29. 21.
    T. Sugimura and S. Sata, Cancer Res: (Suppl.) 43:2415s (1983)Google Scholar
  30. T. Sugimura and M. Nagao, in Mutagenicity: New Horizons in Genetic Toxicology, J. A. Heddle, ed., Academic Press, New York (1982), pp. 73–88.Google Scholar
  31. 22.
    W. W.. Kilgore, D. G. Crosby, A. L. Craigmill, N. K. Poppen, Calif. Agric. 35 (No. 11) (November 1981)Google Scholar
  32. D. G. Crosby, Chem. Eng. News 61:37 (11 April 1983)Google Scholar
  33. C. D. Warren, ibid. (13 June 1983 ), p. 3.Google Scholar
  34. 23.
    H. F. Stich, M. P. Rosin, C. H. Wu, W. D. Powrie, in Mutagenicity: New Horizons in Genetic Toxicology, J. A. Heddle, ed., Academic Press, New York (1982), pp. 117–142;Google Scholar
  35. H. F. Stich, W. D. Powrie, Cancer Lett. 14:251 (1981).Google Scholar
  36. 24.
    N. Katsui, F. Yagihashi, A. Murai, T. Masamune, Bull. Chem. Soc. Jpn. 55:2424 (1982)Google Scholar
  37. N. Katsui, ibid., p. 2428.Google Scholar
  38. R. M. Bostock, R. A. Laine, J. A Kuc, Plant Physiol. 70:1417 (1982).Google Scholar
  39. 25.
    H. Griesebach and J. Ebel, Angew Chem. Int. Ed. Engl. 17:635 (1978).Google Scholar
  40. 26.
    J. M. Concon, D. S. Newburg, T. W. Swerczek, Nutr. Cancer 1 (No. 3):22 (1979).Google Scholar
  41. 27.
    H. W. Renner and R. Munzner, Mutat. Res. 103:275 (1982)Google Scholar
  42. H. W. Renner, Experientia 38:600, (1982)Google Scholar
  43. D. Mourelatos, J. Dozi-Vassiliades, A. Granitsas, Mutat. Res. 104:243 (1982)Google Scholar
  44. J. H. Gans, Toxicol. Appl. Pharmacol. 63:312 (1982).Google Scholar
  45. 28.
    B. Toth, in Naturally Occurring Carcinogens-Mutagens and Modulators: of Carcinogenesis, E. C. Miller, J. A. Miller, I. Hirono, T. Sugimura, S. Takayama, eds., Japan Scientific Societies Press and University Park Press, Tokyo and Baltimore (1979), pp. 57–65Google Scholar
  46. A. E. Ross, D. L. Nagel, B. Toth, J. Agric Food Chem. 30:521 (1982)Google Scholar
  47. B. Toth and K. Patil, Mycopathologia 78:11 (1982)Google Scholar
  48. B. Toth, D. Nagel, A. Ross, Br. J. Cancer 46:417 0982).Google Scholar
  49. 29.
    R. Schoental, Toxicol. Lett. 10:323 (1982)Google Scholar
  50. R. J. Huxtable, Perspect. Biol. Med. 24:1 (1980)Google Scholar
  51. H. Niwa, H. Ishiwata, K. Yamada, J. Chromatogr. 257:146 (1983)Google Scholar
  52. 30.
    M. Chevion and T. Navok, Anal. Biochem. 128:152 (1983)Google Scholar
  53. V. Lattanzio, V: V. Bianco, D. Lafiandra, Experientia 38:789 (1982)Google Scholar
  54. V. L. Flohe, G. Niebch, H. Reiber, Z. Klin. Chem. Klin. Biochem., 9:431 (1971)Google Scholar
  55. J. Mager, M. Chevion, G. Glaser, in Toxic Constituents of Plant Foodstuffs, I. E. Liener, ed., Academic Press, New York (1980), pp: 265–294.Google Scholar
  56. 31.
    J. K. Dunnick, et al., Fundam. Appl. Toxicol. 2:114 (1982).Google Scholar
  57. 32.
    L. C. Berardi and L. A. Goldblatt, in Toxic Constituents of Plant Foodstuffs, I. E. Liener, ed., Academic Press, ed. 2, New York (1980), pp. 183–237.Google Scholar
  58. 33.
    S. P. Xue, in Proceedings, Symposium on Recent Advances in Fertility Regulation, Beijing (2 to 5 September 1980), p. 122.Google Scholar
  59. 34.
    R. K. Haroz and J. Thomasson, Toxicol. Lett. Suppl. 6:72 (1980).Google Scholar
  60. 35.
    M. Coburn, P. Sinsheimer, S. Segal, M. Burgos, W. Troll, Biol. Bull. (Woods Hole, Mass.) 159:468 (1980).Google Scholar
  61. 36.
    C. Campbell, personal communication.Google Scholar
  62. 37.
    G. D. Manners, G. W. Ivie, J. T. MacGregor, Toxicol. Appl. Pharmacol. 45:629 (1978)Google Scholar
  63. G. W. Ivie and D. A. Witzel, in Plant Toxins, vol. 1, Encyclopedic Handbook of Natural Toxins, A. T. Tu and R. F. Keeler, eds., Dekker, New York (in press).Google Scholar
  64. 38.
    J. C. M. Van der Hoeven, et al., in Mutagens in Our Environment, M. Sorsa and H. Vainio, eds., Liss, New York, (1982), pp. 327–338Google Scholar
  65. J. C. M. van der Hoeven, W. J. Lagerweij, I. M. Bruggeman, F. G. Voragen, J. H. Koeman, J. Agric. Food Chem., in press.Google Scholar
  66. 39.
    T. Hirayama and Y. Ito, Prev Med. 10:614 (1981)Google Scholar
  67. E. Hecker, J. Cancer Res. Clin. Oncol. 99:103 (1981).Google Scholar
  68. 40.
    M. R. Malinow, E. J. Bardana, Jr., B. Pirofsky, S. Craig, P. McLaughlin, Science216:415 (1982).Google Scholar
  69. 41.
    B. N. Ames, ibid. 204:587 (1979). “Mutagen” will be used in its broad sense to include clastogens and other DNA-damaging agents.Google Scholar
  70. 42.
    H. F. Stich and R. H. C. San, eds., Short-Term Tests for Chemical Carcinogens, Springer-Verlag, New York (1981).Google Scholar
  71. 43.
    P. Hochstein and S. K. Jain, Fed. Proc. Fed. Am. Soc. Exp. Biol. 40:183 (1981).Google Scholar
  72. 44.
    D. E. Levin, M. Hollstein, M. F. Christman, E. Schwiers, B. N. Ames, Proc. Natl. Acad. Sci. U.S.A. 79:7445 (1982). Many additional quinones and aldehydes have now been shown to be mutagenic.Google Scholar
  73. 45.
    S. G. Carmell, E. J. LaVoie, S. S. Hecht, Food Chem. Toxicol. 20:587 (1982).Google Scholar
  74. 46.
    K. Morimoto, S. Wolff, A. Koizumi, Mutat. Res. Lett. 119:355 (1983)Google Scholar
  75. T. Sawahata and R. A. Neal, Mol. Pharmacol. 23:453 (1983).Google Scholar
  76. 47.
    H. Kappus and H. Sies, Experientia 37:1233 (1981).Google Scholar
  77. 48.
    L. Tikkanen, T. Matsushima, S. Natori, Mutat. Res. 116:297 (1983).Google Scholar
  78. 49.
    P. K. Singal, N. Kapur, K. S. Dhillon, R. E. Beamish, N. S. Dhalla, Can. J. Physiol. Pharmacol. 60:1390 (1982).Google Scholar
  79. 50.
    A Kasamaki, et al., Mutat. Res. 105:387 (1982).Google Scholar
  80. 51.
    J. D. Hendricks, R. O. Sinnhuber, P. M. Loveland, N. E.,Pawlowski, J. E. Nixon, Science 208:309 (1980)Google Scholar
  81. R. A. Phelps, F. S. Shenstone, A. R. Kemmerer, R. J. Evans, Poult. Sci. 44:358 (1964)Google Scholar
  82. N. E. Pawlowski, personal communication.Google Scholar
  83. 52.
    I. Emerit, A. M. Michelson, A. Levy, J. P. Camus, J. Emerit, Hum. Genet. 55:341 (1980).Google Scholar
  84. 53.
    FDA Compliance Program Report of Findings. FY79 Total Diet Studies--Adult (No. 7305.002); available from National Technical Information Service, Springfield, VA). It is estimated that the daily dietary intake of synthetic organic pesticides and herbicides is about 60 g, with chlorpropham, malathion, and DDE accounting for about three-fourths of this. An estimate of 150 /u g of daily exposure in Finland to pesticide residues has been made by K. Hemmimki, H. Vainio, M. Sorsa, S. Salminen [J. Environ. Sci. Health C1 (No. 1), 55 (1983) ].Google Scholar
  85. 54.
    N. K. Hooper, B. N. Ames, M. A. Saleh, J. E. Casida, Science205:591 (1979).Google Scholar
  86. 55.
    L. W. Wattenberg, Cancer Res. (Suppl.)43:2448s (1983).Google Scholar
  87. 56.
    J. Hoey, C. Montvernay, R. Lambert, Am. J. Epidemiol. 113:668 (1981)Google Scholar
  88. A. J. Tuyns, G. Pequignot, M. Gignoux, A. Valla, Int. J. Cancer 30:9 (1982)Google Scholar
  89. A. Tuyns, in Cancer Epidemiology and Prevention, D. Schottenfeld and J. F. Fraumeni, Jr. eds., Saunders, Philadelphia (1982), pp. 293–303Google Scholar
  90. R. G. Ziegler, et al., J. Natl. Cancer Inst. 67:1199 (1981)Google Scholar
  91. W. D. Flanders and K. J. Rothman, Am. J. Epidemiol. 115:371 (1982).Google Scholar
  92. 57.
    E. L. Abel, Hum. Biol. 4:421 (1982)Google Scholar
  93. H. L. Rosset, L. Weiner, A. Lee, B. Zuckerman, E. Dooling, E. Oppenheimer, Obstet. Gynecol. 61:539 (1983).Google Scholar
  94. 57a.
    R. A. Anderson, Jr., B.R. Willins, C. Oswald, L. J. D. Zaneveld, J. Pharmacol. Exp. Ther. 225:479 (1983).Google Scholar
  95. 58.
    H. F. Stich and M. P. Rosin, Int. J. Cancer 31:305 (1983).Google Scholar
  96. 59.
    R. P. Bird, H. H. Draper, P. K. Basrur, Mutat. Res. 101:237 (1982)Google Scholar
  97. M. A. Campbell and A. G. Fantel, Life Sci. 32:2641 (1983).Google Scholar
  98. 60.
    V. J. Feron, A. Kruysse, R. A. Woutersen, Eur. J. Cancer Clin. Oncol. 18:13 (1982).Google Scholar
  99. 61.
    T. Suematsu, et al., Alcoholism: Clin. Exp. Res. 5:427 (1981)Google Scholar
  100. G. W. Winston and A. I. Cederbaum, Biochem. Pharmacol. 31:2301 (1982)Google Scholar
  101. L. A. Videla, V. Fernandez, A. de Marinis, N. Fernandez, A. Valenzuela, Biochem. Biophys. Res. Commun. 104:965 (1982)Google Scholar
  102. T. E. Stege, Res. Commun. Chem. Pathol. Pharmacol. 36:287 (1982).Google Scholar
  103. 62.
    M. G. Cutler and R. Schneider, Food Cosmet. Toxicol. 12:451 (1974).Google Scholar
  104. 63.
    Y. Tazima, in Environmental Mutagenesis. Carcinogenesis and Plant Biology, E. J. Klekowski, Jr., ed., Praeger, New York (1982), vol. 1, pp. 68–95.Google Scholar
  105. 64.
    P. N. Magee, ed Banbury Report 12. Nitrosamines and Human Cancer, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (1982)Google Scholar
  106. P. E. Hartman, in Chemical Mutagens, F. J. de Serres and A. Hollaender, eds., Plenum, New York (1982), vol. 7, pp. 211–294Google Scholar
  107. P. E. Hartman, Environ. Mutagen 5:111 (1983).Google Scholar
  108. 65.
    Committee on Nitrite and Alternative Curing Agents in Food, Assembly of Life Sciences, National Academy of Sciences, The Health Effects of Nitrate, Nitrite, and N-Nitroso Compounds, National Academy Press, Washington, DC (1981).Google Scholar
  109. 66.
    H. F. Stich, P. K. L. Chan, M. P. Rosin, Int. J. Cancer 30:719 (1982)Google Scholar
  110. H. F. Stick and M. P. Rosin, in Nutritional and Metabolic Aspects of Food Safety, M. Friedman. ed., Plenum, New York (in press).Google Scholar
  111. 67.
    L. J. Kinlen, Br. Med. J. 286:1081 (1983)Google Scholar
  112. D. J. Fink and D. Kritchevsky, Cancer Res. 41:3677 (1981).Google Scholar
  113. 68.
    C. W. Welsch and C. F. Aylsworth, J. Natl. Cancer Inst. 70:215 (1983).Google Scholar
  114. 69.
    P. Correa, J. P. Strong, W. D. Johnson, P. Pizzolato, W. Haenszel, J. Chronic Dis. 35:313 (1982).Google Scholar
  115. 70.
    F. B. Shorland, et al., J. Agric. Food Chem. 29:863 (1981).Google Scholar
  116. 71.
    M. G. Simic and M. Karel, eds., Autoxidation in Food and Biological Systems, Plenum, New York (1980).Google Scholar
  117. 72.
    W. A. Pryor, ed. Free Radicals in Biology, Academic Press, New York (1976 to 1982), vols. 1 to 5.Google Scholar
  118. 73.
    H. B. Demopoulos, D. D. Pietronigro, E. S. Flamm, M. L. Seligman, J. Environ. Pathol. Toxicol. 3:273 (1980).Google Scholar
  119. 74.
    F. Bischoff, Adv. Lipid Res. 7:165 (1969).Google Scholar
  120. 75.
    N. L. Petrakis, L. D. Gruenke, J. C. Craig, Cancer Res. 41:2563 (1981).Google Scholar
  121. 76.
    H. S. Black and D. R. Douglas, ibid. 32:2630 (1972).Google Scholar
  122. 77.
    H. Imai, N. T. Werthessen, V. Subramanyam, P. W. LeQuesne, A. H. Soloway, M. Kanisawa, Science207:651 (1980).Google Scholar
  123. 78.
    M. Ferrali, R. Fulceri, A. Benedetti, M. Comporti, Res. Commun. Chem. Pathol. Pharmacol. 30:99 (1980).Google Scholar
  124. 79.
    N. R. Artman, Adv.Lipid Res. 7:245 (1969)Google Scholar
  125. 80.
    J. K. Reddy, J. R. Warren, M. K. Reddy, N. D. Lalwani, Ann. N.Y. Acad. Sci. 386:81 (1982)Google Scholar
  126. J. K. Reddy and N. D. Lalwani, CRC Crit. Rev. Toxicol., in press.Google Scholar
  127. 81.
    H. L. Plaine, Genetics 40:268 (1955)Google Scholar
  128. A. Ito, M. Naito, Y. Naito, H. Watanabe, Gann 73:315 (1982)Google Scholar
  129. G Speit, W. Vogel, M.Wolf, Environ Mutagen, 4:135 (1982)Google Scholar
  130. H. Tsuda, Jpn. J. Genet 56:1 (1981)Google Scholar
  131. N. Hirota and T Yokoyama Gann72:811 (1981).Google Scholar
  132. 82.
    S. Horie, H. Ishii, T. Suga, J. Biochem. (Tokyo) 90:1691 (1981)Google Scholar
  133. D. P. Jones, L. Eklow, H. Thorn S. Orrenius, Arch. Biochem. Biophys. 210:505 (1981).Google Scholar
  134. 83.
    B. Chance, H. Sies, A. Boveris, Physiol. Rev. 59:527 (1981).Google Scholar
  135. 84.
    D. Harman, Proc. Natl. Acad. Sci. U.S.A. 78:7124 (1981)Google Scholar
  136. in Free Radicals in Biology, W. A. Pryor, ed., Academic Press, New York (1982), vol. 5, pp. 255–275.Google Scholar
  137. 85.
    I. Emerit, M. Keck, A. Levy, J. Feingold, A. M. Michelson, Mutat. Res. 103:165 (1982).Google Scholar
  138. 86.
    C. E. Neat, M. S. Thomassen, H. Osmundsen, Biochem. J. 196:149 (1981)Google Scholar
  139. J. Bremer and K. R. Norum, J. Lipid Res. 23:243 (1982)Google Scholar
  140. M. S. Thomassen, E. N. Christiansen, K. R. Norum, Biochem J. 206:195 (1982)Google Scholar
  141. H. Osmundsen, Int. J. Biochem. 14:905 (1982)Google Scholar
  142. J. Norseth and M. S. Thomassen, Biochem. Biophys. Acta, in pressGoogle Scholar
  143. 87.
    M. G. Enig, R. J. Munn, M. Keeney, Fed. Proc. Fed. Am. Soc. Exp. Biol. 37:2215 (1978)Google Scholar
  144. J. E. Hunter, J. Natl. Cancer Inst. 69:319 (1982)Google Scholar
  145. A. B.: Awad, ibid., p. 320Google Scholar
  146. H Ruttenberg, L. M. Davidson, N. A Little, D. M. Klurfeld, D. Kritchevsky, J. Nutr. 113:835 (1983).Google Scholar
  147. 88.
    R. Wood, Lipids 14:975 (1979).Google Scholar
  148. 89.
    E. N. Christiansen, T. Flatmark, H. Kryvi, Eur. J. Cell Biol. 26:11 (1981).Google Scholar
  149. 90.
    Council for Agricultural Science and Technology, Diet, Nutrition, and Cancer: A Critique(Special Publication 13 ), Council for Agricultural Science and Technology, Ames, Iowa (1982).Google Scholar
  150. 91.
    L. F. Bjeldanes, et al., Food Chem. Toxicol. 20:357 (1982)Google Scholar
  151. M. W. Pariza, L. J. Loretz, J. M. Storkson, N. C. Holland, Cancer Res. (Suppl.) 43:2444s (1983).Google Scholar
  152. 92.
    H. F. Stich, W. Stich, M. P Rosin, W. D. Powrie, Mutat: Res. 91:129 (1981)Google Scholar
  153. M. P. Rosin, H. F. Stich, W. D. Powrie, C. H. Wu, ibid. 101:189 (1982)Google Scholar
  154. C.-I. Wei, K. Kitamura, T. Shibamoto, Food Cosmet. toxicol. 19: 749 (1981).Google Scholar
  155. 93.
    E. Yamasaki and B. N. Ames, Proc. Natl. Acad. Sci. U.S.A. 74:3555 (1977).Google Scholar
  156. 94.
    R. Baker, A. Arlauskas, A. Bonin, D. Angus, Cancer Lett. 16:81 (1982).Google Scholar
  157. 95.
    D. Schuetzle, D. Cronn, A. L. Crittenden, R. J. Charlson, Environ. Sci. Technol. 9:838 (1975)Google Scholar
  158. G. Gartreil and S. K. Friedlander, Atmos. Environ. 9:279 (1975)Google Scholar
  159. L. D. Kier, E. Yamasaki, B. N. Ames, Proc. Natl. Acad. Sci. U.S.A. 71:4159 (1974)Google Scholar
  160. J. N. Pitts, Jr., Environ Health Perspect. 47:115 (1983).Google Scholar
  161. 96.
    J. E. Ven Am. J. Epidemiol. 116:42 (1982)Google Scholar
  162. R. Cederiof, R. Doll, B. Fowler, Environ. Health Perspect. 22:1 (1978)Google Scholar
  163. F. E Speizer, ibid. 47:33 (1983).Google Scholar
  164. 97.
    B. Brunekreef and J. S. M. Boleij, Int. Arch. Occup. Environ. Health50:299 (1982).Google Scholar
  165. 98.
    H. Kasai, et al., Gann73:681 (1982).Google Scholar
  166. 99.
    V. Armuth and I. Berenblum, Carcinogenesis2:977 (1981).Google Scholar
  167. 100.
    S. Frabro, Reprod. Toxicol. 1:2 (1982).Google Scholar
  168. 101.
    D. Trichopoulos, M. Papapostolou, A. Polychronopoulou, Into J. Cancer 28:691,(1981)Google Scholar
  169. P. Hartge, L. P. Lesher, L. McGowan, R. Hoover, ibid. 30:531, (1982)Google Scholar
  170. B. MacMahon, Cancer (Brussels) 50:267.6 (1982)Google Scholar
  171. H. S. Cuckle and L. J. Kinlen, Br. J. Cancer 44:760 (1981)Google Scholar
  172. R. L. Phillips and D. A. Snowdon, Cancer Res. (Suppl.) 43:2403s (1983)Google Scholar
  173. L. D. Marrett, S. D. Walter, J. W Meigs, Am. J. Epidemiol. 117:113 (1983)Google Scholar
  174. D. M. Weinberg R K. Ross, T. M. Mack, A. Paganini-Hill, B E. Henderson, Cancer (Brussels) 51:675 (1983).Google Scholar
  175. 102.
    P. E. Hartman, Environ. Mutagen., in pressGoogle Scholar
  176. 103.
    J. R. Totter, Proc. Natl. Acad. Sci. U.S.A. 77:1763 (1980).Google Scholar
  177. 104.
    I. Fridovich, in Pathology of Oxygen., A. Autor, ed., Academic Press, New York (1982), pp. 1–19Google Scholar
  178. L. W. Oberley, T. D. Oberly, G. R. Buettner, Med. Hypotheses 6:249 (1980).Google Scholar
  179. 105.
    B. Halliwell, Cell. Biol. Into Rep. 6:529 (1982)Google Scholar
  180. A, I. Tauber, Trends Biochem. Sci. 7:411 (1982)Google Scholar
  181. A. B. Weitberg, S. A. Weitzman, M. Destrempes, S. A. Latt, T. P. Stossel, N. Engl. J. Med. 308:26 (1983). Neutrophils also produce HOC1, which is both a chlorinating and oxidizing agent.Google Scholar
  182. 106.
    M. A. Trush, E. G. Mimnaugh, T. E. Gram, Biochem. Pharmacol. 31:3335 (1982)Google Scholar
  183. 107.
    L. Flohe, in Free Radicals in Biology, W. A. Pryor, ed., Academic Press, New York (1982), vol. 5 pp. 223–254.Google Scholar
  184. 108.
    C. Lind, P. Hochstein, L. Ernster, Arch. Biochem. Biophys. 216:178 (1982).Google Scholar
  185. 109.
    M. Warholm, C. Guthenberg, B. Mannervik, C. von Bahr, Biochem. Biophys. Res. Commun. 98:512 (1981).Google Scholar
  186. 110.
    J. G. Bieri, L. Corash, V. S. Hubbard, N. Eng. J. Med. 308:1063 (1983).Google Scholar
  187. 111.
    Y. M. Wang, et al., in Molecular Interrelations of Nutrition and Cancer, M. S. Arnott, J. van Eys, Y.-M. Wang, eds., Raven, New York (1982), pp. 369–379.Google Scholar
  188. 112.
    C. Beckman, R. M. Roy, A. Sproule, Mutat. Res. 105:73 (1982)Google Scholar
  189. M. G. Cook and P. McNamara, Cancer Res. 40:1329 (1980).Google Scholar
  190. 113.
    K. J. A. Davies, A. T. Quintanilha, G. A. Brooks, L. Packer, Biochem. Biophys. Res. Commun. 107:1198 (1982).Google Scholar
  191. 114.
    C. S. Foote, in Pathology of Oxygen, A. Autor, ed., Academic Press, New York (1982), pp. 21–44Google Scholar
  192. J. E. Packer, J. S. Mahood, V. 0. Mora-Arellano, T. F. Slater, R. L. Willson, B. S. Wolfenden, Biochem. Biophys. Res. Commun. 98:901 (1981)Google Scholar
  193. W. Bors, C. Michel, M. Saran, Bull. Eur. Physiopathol. Resp. 17 (Suppl.):13, (1981).Google Scholar
  194. 115.
    N. I. Krinsky and S. M. Deneke, J. Natl. Cancer Inst. 69:205 (1982)Google Scholar
  195. J. A. Turner and J. N. Prebble, J. Gen. Microbiol. 119:133 (1980)Google Scholar
  196. K. L. Simpson and C. O. Chichester, Annu. Rev. Nutr. 1:351 (1981).Google Scholar
  197. 116.
    G. Rettura, C. Dattagupta, P. Listowsky, S. M. Levenson, E. Seifter, Fed. Proc. Fed. Am. Soc. Exp. Biol. 42:786 (1983)Google Scholar
  198. M. M. Mathews-Roth, Oncology 39:33 (1982).Google Scholar
  199. 117.
    R. Peto, R. Doll, J. D. Buckley, M. B. Sporn, Nature (London) 290:201 (1981)Google Scholar
  200. R. B. Shekelle, et al., Lancet, 1981-II, 1185 (1981)Google Scholar
  201. T. Hirayama, Nutr. Cancer, 1:67 (1979)Google Scholar
  202. G. Kvale, E. Bjelke, J. J. Gart, Int. J. Cancer 31:397 (1983)Google Scholar
  203. 118.
    W. A. Pryor, M. Tamura, M. M. Dooley, P. I. Premovic, D. F. Church, in Oxy-Radicals and Their Scavenger Systems: Cellular and Medical Aspects, G. Cohen and R. Greenwald, eds., Elsevier, Amsterdam (1983), vol. 2, pp. 185–192Google Scholar
  204. W. A. Pryor, B. J. Hales, P. I. Premovic, D. F. Church, Science220:425 (1983).Google Scholar
  205. 119.
    M. M. Mathews-Roth, J. Natl. Cancer Inst. 69:279 (1982).Google Scholar
  206. 120.
    A. C. Griffin, in Molecular Interrelations of Nutrition and Cancer, M. S. Arnott, J. Vaneys, Y. M. Wang, eds., Raven, New York (1982), pp. 401–408Google Scholar
  207. D. Medina, H. W. Lane, C. M. Tracey, Cancer Res. (Suppl.)43:2460s (1983)Google Scholar
  208. M. M. Jacobs, Cancer Res. 43:1646 (1983)Google Scholar
  209. H. J. Thompson, L. D. Meeker, P. J. Becci, S. Kokoska, ibid. 42:4954 (1982)Google Scholar
  210. D. F. Birt, T. A. Lawson, A. D. Julius, C. E. Runice, S. Salmasi, ibid., p. 4455Google Scholar
  211. C. Witting, U. Witting, V. Krieg, J. Cancer Res. Clin. Oncol. 104:109 (1982).Google Scholar
  212. 121.
    M. Chatterjee and M. R. Banerjee, Cancer Lett. 17:187 (1982).Google Scholar
  213. 122.
    W. C. Willett, et al., Lancet, 1983-II, 130 (1983).Google Scholar
  214. 123.
    J. T. Salonen, G. Alfthan, J. Pikkarainen, J. K. Huttunen, P. Puska, ibid., 1982 - I1, 175 (1982).Google Scholar
  215. 124.
    M. Yonaha, E. Itoh. Y. Ohbayashi, M. Uchiyama, Res. Commun. Chem. Pathol. Pharmacol. 28:105 (1980)Google Scholar
  216. L. J. Kling and J. H. Soares, Jr., Nutr. Rep. Into 24:29 (1981).Google Scholar
  217. 125.
    Tateishi, T. Higashi, A. Naruse, K. Hikita, Y. Sakamoto, J. Biochem. (Tokyo)90:1603 (1981).Google Scholar
  218. 126.
    J. M. Williamson, B. Boettcher, A. Meister, Proc. Natl. Acad. Sci. U.S.A. 79:6246 (1982).Google Scholar
  219. 127.
    CME Symposium on “N-Acetylcysteine (NAC): A Significant Chemoprotective Adjunct,” Sem. Oncol. 10 (Suppl. l):1 (1983).Google Scholar
  220. 128.
    J. A. Hinson, L. R. Pohl, T. J. Monks, J. R. Gillette, Life Sci. 29:107 (1981).Google Scholar
  221. 129.
    A. M. Novi, Science212:541 (1981).Google Scholar
  222. 130.
    W. B. Dunham, et al., Proc. Natl. Acad. Sci. U.S.A. 79:7532 (1982)Google Scholar
  223. G. Kallistratos and E. Fasske, J. Cancer Res. Clin. Oncol. 97:91 (1980).Google Scholar
  224. 131.
    S. Wassertheil-Smoller, et al., Am. J. Epidemiol. 114:714 (1981).Google Scholar
  225. 132.
    B. N. Ames, R. Cathcart, E. Schwiers, P. Hochstein, Proc. Natl. Acad. Sci. U.S.A. 78:6858 (1981).Google Scholar
  226. 133.
    A. Nomura, L. K. He i lbrun, G. N. Stemmermann, in preparation.Google Scholar
  227. 134.
    J. N. Boyd, J. D. Babish, G. S. Stoewsand, Food Chem. Toxicol. 20:47 (1982).Google Scholar
  228. 135.
    A. W. Wood, et al., Proc. Natl. Acad. Sci. U.S.A. 79:5513 (1982).Google Scholar
  229. 136.
    T. H. Maugh II, Science 205:1363 (1979) (interview with John Higginson).Google Scholar
  230. 137.
    H. L. Gensler and H. Bernstein, Q. Rev. Biol. 6:279 (1981).Google Scholar
  231. 138.
    A. L. Tappel, in Free Radicals in Biology, W. A. Pryor, ed., Academic Press, New York (1980), vol. 4, pp. 1–47.Google Scholar
  232. 139.
    R. S: Sohal, in Age Pigments, R. S. Sohal, ed., Elsevier/North-Holland, Amsterdam (1981), pp. 303–316.Google Scholar
  233. 140.
    J. E. Fleming, J. Miquel, S. F. Cottrell, L. S. Yengovan, A. C. Economos, Gerontology28:44 (1982).Google Scholar
  234. 141.
    J. M. Tolmasoff, T. Ono, R. G. Cutler, Proc. Natl. Acad. Sci. U.S.A. 77:2777 (1980)Google Scholar
  235. R. G. Cutler, Gerontology, in pressGoogle Scholar
  236. J. L. Sullivan, ibid. 28:242 (1982).Google Scholar
  237. 142.
    R. Peto, Proc.. Soc. London Ser. B 205:111 (1979)Google Scholar
  238. D. Dix, P. Cohen, J. Flannery, J. Theor. Biol. 83:163 (1980).Google Scholar
  239. 143.
    R. G. Cutler, in Testing the Theories of Aging, R. Adelman and G. Roth, eds., CRC Press, Boca Raton, FL, (in press).Google Scholar
  240. 144.
    D. Hersh, R. G.: Cutler, B. N. Ames, in preparation.Google Scholar
  241. 145.
    E. Boyland, in Health Risk Analysis, Franklin Institute Press, Philadelphia (1980), pp. 181–193Google Scholar
  242. E. Boyland, in Cancer Campaign vol. 6, Cancer Epidemiology, E. Grundmann, ed., Fischer, Stuttgart (1982), pp. 125–128.Google Scholar
  243. 146.
    J. L. Marx, Science 219:158 (1983).Google Scholar
  244. 147.
    B. D. Goldstein, G. Witz, M. Amoruso, D. S. Stone, W. Troll, Cancer Lett. 11:257 (1981)Google Scholar
  245. W. Troll, in Environmental Mutagens and Carcinogens, T. Sugimura, S. Kondo, H. Takebe, eds., Univ. of Tokyo Press, Tokyo and Liss, New York (1982), pp. 217–222.Google Scholar
  246. 148.
    B. N. Ames, M. C. Hollstein, R. Cathcart, in Lipid Peroxide in Biology and Medicine, K. Yagi, ed., Academic Press, Near York (1982), pp. 339–351.Google Scholar
  247. 149.
    I . Emerit and P. A. Cerutti, Proc. Natl. Acad. Sci. U.S.A. 79:7509 (1982)Google Scholar
  248. Nature (London) 293:144 (1981)Google Scholar
  249. P. A. Cerutti, I. Emerit, P. Amstad, in Genes and Proteins in Oncogenesis, I. B. Weinstein and H. Vogel, eds., Academic Press, New York (in press)Google Scholar
  250. I. Emerit, A. Levy, P. Cerutti, Mutat. Res. 110:327 (1983).Google Scholar
  251. 150.
    Funes and M. Karel, Lipids16:347 (1981).Google Scholar
  252. 151.
    S. J. Stohs, M. Q. Hassan, W. J. Murray, Biochem. Biophys. Res. C ommun. 111:854 (1983).Google Scholar
  253. 152.
    C. C. Reddy, R. W Scholz, E. J. Massaro, Toxicol. Appl. Pharmacol. 61:460 (1981).Google Scholar
  254. 153.
    H. Nagasawa and J B Little, Carcinogenesis 2:601 (1981)Google Scholar
  255. V. Solanki, R. S. Rana, T. J. Slaga, ibid., p. 1141Google Scholar
  256. T. W. Kens ler and M. A. Trush, Cancer Res. 41:216 (1981).Google Scholar
  257. 154.
    R. H. Simon, C. H. Scoggin, D. Patterson, J Biol. Chem. 256:7181 (1981)Google Scholar
  258. T. S. Argyris and T. J. Slaga, Cancer Res. 41:5193 (1981).Google Scholar
  259. 155.
    G. E. Hatch, D. E. Gardner, D. B. Menzel, Environ. Res. 23:121 (1980).Google Scholar
  260. 156.
    A. J. P. Klein-Szanto and T. J. Slaga, J. Invest. Dermatol. 79:30 (1982).Google Scholar
  261. 157.
    C. C. Weddle, K. R. Hornbrook, P. B. McCay, J. Biol. Chem. 251:4973 (1976).Google Scholar
  262. 158.
    A. G. Lurie and L. S. Cutler, J. Natl. Cancer Inst. 63:147 (1979).Google Scholar
  263. 159.
    C. Borek and W. Troll, Proc. Natl. Acad. Sci. U.S.A. 80:1304 (1983)Google Scholar
  264. C. Borek, in Molecular Interrelations of Nutriton and Cancer, M. S. Arnott, J. van Eys, Y.-M. Wang, eds., Raven, New York (1982), pp 337–350.Google Scholar
  265. 160.
    T. J. Slaga, et al., in Carcinogenesis: A Comprehensive Treatise, Raven, New York (1982), vol. 7 pp. 19–34Google Scholar
  266. K. Ohuchi and L. Levine, Biochem. Biophys. Acta 619:11 (1980)Google Scholar
  267. S. M. Fischer, G. D. Mills, T. J. Slaga, Carcinogenesis3:1243 (1982).Google Scholar
  268. 161.
    R. P. Mason, in Free Radicals in Biology, W. A. Pryor, ed., Academic Press, New York (1982), vol. 5, pp. 161–222.Google Scholar
  269. 162.
    G. McLennan, L. W. Oberley, A. P. Autor, Radiat. Res. 84:122 (1980).Google Scholar
  270. 163.
    J. M. Parry, E. M. Parry, J. C. Barrett, Nature (London) 294:263 (1981)Google Scholar
  271. A. R. Kinsella, Carcinogenesis 3:499 (1982).Google Scholar
  272. 164.
    H. C. Birnboim, Can. J. Physiol. Pharmacol. 60:1359 (1982)Google Scholar
  273. 165.
    A. Varshavsky, Cell 25:561 (1981).Google Scholar
  274. 166.
    T. J. Powles:, et al., eds., Prostaglandins and Cancer: First International Conference, Liss, New York (1982).Google Scholar
  275. 167.
    J. E. Trosko, C.-C. Chang, A. Medcalf, Cancer Invest., in pressGoogle Scholar
  276. 167a.
    B. Weinstein, Nature (London) 302:750 (1983).Google Scholar
  277. 168.
    J. A. Bond, A. M. Gown, H. L. Yang, E. P. Benditt, M. R. Juchau, J. Toxicol. Environ. Health 7:327 (1981).Google Scholar
  278. 169.
    Editorial, Lancet, 1980-I, 964, (1980)Google Scholar
  279. K. Yagi, H. Ohkawa, N Ohishi, M Yamashita, T. Nakashima, J. Appl. Biochem. 3:58 (1981).Google Scholar
  280. 170.
    J. M. C Gutteridge, B. Halliweli, D. A. Rowley, T. Westermarck, Lancet, 1982-II, 459 (1982).Google Scholar
  281. 171.
    J. E. Cleaver, in Metabolic Basis of Inherited Disease, J. B. Stanbury, J. B. Wyngaarden, D. S. Fredrickson, J. L. Goldstein, eds. McGraw-Hill, ed. 5, New York (1983), pp. 1227–1250.Google Scholar
  282. 172.
    K. C. Bhuyan, D. K. Bhuyan, S. M. Podos, IRCS Med. Sci. 9:126 (1981)Google Scholar
  283. A. Spector, R. Scotto, H. Weissbach, N. Brot, Biochem. Biophys. Res. Commun. 108:429 (1982)Google Scholar
  284. S. D. Varma, N. A. Beachy, R. D. Richards, Photochem. Photobiol. 36:623 (1982).Google Scholar
  285. 173.
    M. L. Katz, K. R. Parker, G. J. Handelman, T. L. Bramel, E. A. Dratz, Exp. Eye Res. 34:339, (1982).Google Scholar
  286. 174.
    D Behne, T. Hofer, R. von Berswordt-Wallrabe, W. Elger, J. Nutr. 112:1682 (1982).Google Scholar
  287. 175.
    B. N. Ames, L. S. Gold, C. B. Sawyer, W. Havender, in Environmental- Mutagens and Carcinogens, T. Sugimura, S. Kondo, H. Takebe, eds., Univ. of Tokyo Press, Tokyo, and Liss, New York (1982), pp. 663–670.Google Scholar
  288. 176.
    National Center for Health Statistics, Advance Report, Final Mortality Statistics, 1979; Monthly Vital Statistics Report31, No. 6, suppl. [.DHHS publication (PH.S) 82-1120., Public Health Service, Hyattsville, MD, 1982]; Metropolitan Life Insurance Company Actuarial Tables, April 1983.Google Scholar
  289. 177.
    B. A. Bridges, B. E. Butterworth, I. B. Weinstein, eds., Banbury Report 13. Indicators of Genotoxic Exposure, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (1982)Google Scholar
  290. R. Montesano, M. F. Rajewsky, A. E. Pegg, E. Miller, Cancer Res. 42:5236 (1982)Google Scholar
  291. H. F. Stich, R. H. C. San, M. P. Rosin, Ann. N.Y. Acad. Sci., in pressGoogle Scholar
  292. I. B. Weinstein, Annu. Rev. Public Health 4:409 (1983).Google Scholar
  293. 178.
    I am indebted to G. Ferro-Luzzi Ames, A. Blum, L. Gold, P. Hartman, W. Havender, N. K. Hooper, G. W. Ivie, J. McCann, J. Mead, R. Olson, R. Peto, A. Tappel, and numerous other colleagues for their criticisms. This work was supported by DOE contract DE-AT03-76EV70156 to B.N.A. and by National Institute of Environmental Health Sciences Center Grant ES01896. This article has been expanded from a talk presented at the 12th European Environmental Mutagen Society Conference, Espoo, Finland, June 1982 [in Mutagens in Our Environment, M. Sorsa and H. Vainio, eds., Liss, New York (1982)]. 1 wish to dedicate this article to the memory of Philip Handler, pioneer in the field of oxygen radicals.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Bruce N. Ames
    • 1
  1. 1.Department of BiochemistryUniversity of CaliforniaBerkeleyUSA

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