Functional Differences Associated with Quantitative Distribution of Ia Antigens on Mouse B Cells

  • E. M. Andrew
  • N. M. Mackenzie
  • R. M. E. Parkhouse


Cellular interaction, the sine qua non of the immune system, is based on ligand-receptor systems expressed on the surface of the interacting cell types. Our understanding of the cellular functioning of the immune system has been made possible largely through the use of antibodies to surface molecules which are selectively expressed on subpopulations of lymphocytes at different stages of their development. In many studies the emphasis has been on the association of cell function with the presence or absence of a particular surface marker1–3. In other words, the function of the cell has been correlated with operationally qualitative differences in marker expression.


Secondary Response Staining Reagent Unmodulated Cell Interact Cell Type Adoptive Transfer System 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • E. M. Andrew
    • 1
  • N. M. Mackenzie
    • 1
  • R. M. E. Parkhouse
    • 1
  1. 1.National Institute for Medical ResearchLondonUK

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