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A Double Blind Comparison of Pirlindole with Amitriptyline and Imipramine

  • O. Schäpperle
  • F. Eckmann
  • H. Immich

Summary

Comparisons of the efficacy of the antidepressants pirlindole1 and amitriptyline, and of pirlindole and imipramine were performed in two controlled, randomised, double-blind 2-centre studies in 80 depressed in-patients each. With regard to the therapeutic efficacy in depressive syndromes of nosologically different classification, no relevant and statistically significant differences were observed either in the comparison of amitripytline versus pirlindole nor in that between imipramine and pirlindole. In both studies, no intolerance phenomena, no relevant side effects, or abnormal laboratory parameters were seen under pirlindole, amitriptyline or imipramine.

Keywords

Double Blind Comparison Depressive Syndrome Antidepressive Efficacy Psychopathological State Relevant Side Effect 
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References

  1. 1.
    M. D. Mashkovskij, N.I. Andrejeva, “Pharmacological Properties of 2,3,3a,4,5,6,-Hexahydro-8- methyl-IH-pyrazino (3,2,1,-j,k) carbazol Hydrochloride (PIRLINDOLE), a new Antidepressant.” Arzneimittelforschung 31, (I) Nr. 1 (1981) 75–79Google Scholar
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    H. Immich, F. Eckmann, H. Neumann, O. Schäpperle, H. Schwarz, H. Tempel, “Grundlegende Probleme bei der Antidepressiva-Priifung.” 2. Mitteilung Arzneimittelforschung 21, Nr. 5 (1971) 644–649Google Scholar
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    H. Immich, F. Eckmann, “Zur Planung und Auswertung von klinischen Psychopharmaka- priifungen”. in: “Reihe Psychopathometrie: Messungen und MeBverfahren in der Psychopathologie.” Erzigkeit, Lehrl, Blaha, Heerklotz, VLESS-Verlag 1979.Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • O. Schäpperle
    • 1
  • F. Eckmann
    • 1
  • H. Immich
    • 1
  1. 1.Nervenklinik MorijaBielefeldGermany

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