Abstract
Seventeen patients with intracerebral neoplasms were treated with intra-arterial mitomycin-c 7.5–18 mg/m2 at 6–9 week intervals. Most were heavily pretreated. Three of 8 evaluable patients with brain metastases, a single patient with a primitive neuroectodermal tumor, and 0 of 6 with glioblastomas responded to treatment. The activity of this regimen to date has been impressive considering the patient population treated. Neurological and ocular toxicity were dose-limiting. We recommend a mitomycin-c dose of 15 mg/m2 every 6–9 weeks for further studies.
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© 1986 Martinas Nijhoff Publishers, Boston
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Stewart, D.J. et al. (1986). Phase I study of intraarterial mitomycin-c for recurrent intracerebral tumors. In: Walker, M.D., Thomas, D.G.T. (eds) Biology of Brain Tumour. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2297-9_65
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DOI: https://doi.org/10.1007/978-1-4613-2297-9_65
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