Amyloidosis pp 483-489 | Cite as
Appearance of Systemic Amyloidosis in Myeloma with Amyloidogenic Bence Jones Protein
Abstract
The patient (K. Kor), 55 year old female, had two phases of clinical manifestations in the course. The first one year is characterized by myeloma giving rise to osteolytic lesions, plasma cell proliferations in the bone marrow and urinary BJP of lambda type. Subsequent 8 months manifested amyloidosis with another variety of manifestations, including low voltage with sick sinus syndrome in ECG, progressive fall of blood pressure and macroglossia with amyloid deposits demonstrated by biopsy. It is noteworthy that the urinary excretion of BJP has decreased in amount along with the appearance of amyloidosis, suggestive of different catabolism of BJP in amyloidosis. The BJP, easily formed viscous precipitated in vitro, belong to V I-2 (sub-subgroup) washih is presumably amyloidogenic in character.
Keywords
Carpal Tunnel Syndrome Osteolytic Lesion Cardiac Amyloidosis Systemic Amyloidosis Sick Sinus SyndromePreview
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