Immunological Analysis of the Avian Progesterone Receptor

  • D. O. Toft
  • W. B. Sullivan
  • D. F. Smith
  • T. G. Beito
  • C. J. Krco
Chapter

Abstract

Although the avian progesterone receptor has been purified and investigated extensively, its structure and composition remain unclear. The nontransformed receptor in cytosol extracts exists as two major forms, I and II, which differ in size and in ionic properties (1,2). Both forms I and II are large 8S protein complexes which contain a common 90,000-dalton protein in addition to the hormone binding protein or receptor. This 90,000-dalton protein has been recently identified as heat shock protein 90 (hsp90) (3–5), one of the major heat shock proteins found in eukaryotic cells. Also, the same protein has been shown to form complexes with other steroid receptors from the chicken (6,7), and may thus be a common element of all nontransformed receptors.

Keywords

Progesterone Receptor Steroid Receptor Sodium Molybdate Sedimentation Analysis Human Uterus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • D. O. Toft
    • 1
  • W. B. Sullivan
    • 1
  • D. F. Smith
    • 1
  • T. G. Beito
    • 2
  • C. J. Krco
    • 2
  1. 1.Department of Biochemistry and Molecular BiologyMayo Medical SchoolRochesterUSA
  2. 2.Department of ImmunologyMayo Medical SchoolRochesterUSA

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