Calcium Metabolism in Essential Hypertensive Patients Treated with Etozolin
Abstract
Calcium and Phosphate metabolism abnormalities have been shown to be present either in experimental (1) or in clinical studies (2) in essential hypertension (E.H.). Among these, the most frequent relief is an overactivity of the parathyroid glands (3). Furthermore diuretics as thiazides commonly employed in such pathological condition, as first step therapy, exert some well known actions on mineral metabolism: a reduction of Ca excretion in hypercalciuric states (4), a modification of Ca intestinal absorption (5) and an increased bone mineralization (6). From these considerations, we have investigated, in E.H. patients (pts), the effects on mineral metabolism induced by Etozolin (E) a diuretic compound acting on Henle’s loop (7) with a considerable antihypertensive property (8).
Keywords
Uric Acid Essential Hypertension Mineral Metabolism Calcium Metabolism Include Blood PressurePreview
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References
- 1.Holloway, E.T., Bohr, D.F. Circul. Res. 33: 678–685, 1973.Google Scholar
- 2.Mc Carron, D.A. N. Engl. J. Med. 307: 226–228, 1982.CrossRefGoogle Scholar
- 3.Mc Carron, D.A., Pingree, P., Rubin, R.J., Gaucher, S.M., Molitch, M., Kurtzik, S. Hypertension 2: 162–168, 1980.Google Scholar
- 4.Yendt, E.R., Cohanim, M. Kidney Int. 13: 397–402, 1978.PubMedCrossRefGoogle Scholar
- 5.Barilla, D.E., Tolentino, R., Kaplan, R.A., Pak, C.Y.C. Metabolism 27: 125–131, 1978.PubMedCrossRefGoogle Scholar
- 6.Wasnich, R.D., Benfante, R.J., Yano, K., Heilbrun, L., Vogel, J.M. New Engl. J. Med. 309: 344–346, 1983.PubMedCrossRefGoogle Scholar
- 7.Greven, J. Heidenreich, O. Arzneimittel-Forschung-Drug Res. 27: 1755–1757, 1977.Google Scholar
- 8.Kopp, H. Fortschritte der Medizin 96: 1194–1198, 1978.PubMedGoogle Scholar
- 9.Scheitza, E. Arzneimittel-Forschung 27: 1807–1814, 1977.PubMedGoogle Scholar
- 10.Morachiello, P., Coli, U., Landini, S., Fracasso, A., Righetto, F., Scanferla, F., Bazzato, G. In: Mineral Metabolism Res. in Italy (Wichtig Ed. Milan) 1985, in press.Google Scholar