Monomerization of Cytochrome Oxidase might be Essential for Subunit III Removal

  • Moshe Finel

Abstract

A present discrepancy in the study of proton translocation by cytochrome oxidase is whether removal of subunit III (suIII) abolishes proton pumping (1) or not (2). We have recently suggested that monomerization of the dimeric enzyme rather than suIII removal reduces the pumping efficiency (3). The present report tries to clarify the interaction between suIII removal and monomerization of cytochrome oxidase and suggests that monomerization might be a prerequisite for suIII removal.

Keywords

Cytochrome Oxidase Sucrose Gradient Oligomeric State Present Discrepancy Proton Translocation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    M. Thelen, P.S. O’Shea, G. Petrone, and A. Azzi (1985) J. Biol. Chem. 260, 3626–3631.Google Scholar
  2. 2.
    I. Puettner, E. Carafoli, and F. Malatesta (1985) J. Biol. Chem. 260, 3719–3723.Google Scholar
  3. 3.
    M. Finel and M. Wikstrbm (1986) Biochem. Biophys. Acta 851, 99–108.CrossRefGoogle Scholar
  4. 4.
    F. Malatesta, G. Georgevich, and R.A. Capaldi (1983) in ( E. Quagliariello and F. Palmieri, eds.) Structure and Function of Membrane Proteins, Elsevier, Amsterdam, pp. 223–235.Google Scholar
  5. 5.
    N.C. Robinson and L. Talbert (1986) Biochemistry 25, 2328–2335.CrossRefGoogle Scholar
  6. 6.
    T. Penttila (1983) Eur. J. Biochem. 133, 355–361.CrossRefGoogle Scholar
  7. 7.
    K. Bill and A. Azzi (1982) Biochem. Biophys. Res. Commun. 106, 1203–1209.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Moshe Finel
    • 1
  1. 1.Department of Medical ChemistryUniversity of HelsinkiHelsinkiFinland

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