Circulating cells in Hodgkin’s disease

  • M. Ruud Halie
  • Ben E. de Pauw
  • Jan W. Smit
Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 41)

Abstract

The mode of spread of Hodgkin’s disease within the body has been a subject of controversy [1–4]. One feature of lymphomas is that they originate from cells that have the potential to circulate. This should influence our thoughts about the ways the disease progresses and disseminates. The concept of lymphatic spread in the initial phase of Hodgkin’s disease as favored by Kaplan has been opposed by the ideas of early hematogenous spread [2–4]. The different views have consequences for the approach to therapy. The results of local radiotherapy in localized Hodgkin’s disease supported the opinion of Kaplan [5, 6]. However, further improvement in radiotherapy results has been achieved by the introduction of extended field irradiation [7]. This therapy can not be considered as being restricted to lymph nodes alone, but it also harbors an element of more systemic therapy since lymphocytes in adjacent noninvolved lymph nodes and circulating blood cells are also exposed. The finding that impaired cellular immunity occurred in stages of the disease that were considered to be restricted to one or two lymph node groups can be taken as an argument against a purely local disorder [8, 9].

Keywords

Herpes Zoster Infectious Mononucleosis Large Granular Lymphocyte Hematogenous Dissemination Basophilic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Kluwer Academic Publishers, Boston 1989

Authors and Affiliations

  • M. Ruud Halie
  • Ben E. de Pauw
  • Jan W. Smit

There are no affiliations available

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