Synthesis and Therapeutic Effect of New <Emphasis Type="Italic">Cis</Emphasis>-Platinum Complexes on Experimental Tumors

R. Voegeli; J. Pohl; P. Hilgard; J. Engel; W. Schumacher; H. Brunner; M. Schmidt; U. Holzinger; H. Schönenberger

doi:10.1007/978-1-4613-1717-3_40

Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy pp 343-347 | Cite as

Synthesis and Therapeutic Effect of New Cis-Platinum Complexes on Experimental Tumors

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Authors and affiliations

R. Voegeli
J. Pohl
P. Hilgard
J. Engel
W. Schumacher
H. Brunner
M. Schmidt
U. Holzinger
H. Schönenberger

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Part of the Developments in Oncology book series (DION, volume 54)

Abstract

The substitution of the two NH₃ groups in cisplatinum (cDDP) by ethylene diamine ligands leads to complexes with good pharmacological activity against experimental tumors (1). Our aim was to increase the activity/toxicity ratio and also to provide compounds against tumors which are either nonresponsive or resistant to cisplatinum. We prepared new platinum complexes of 1,2-diaminoethanes derived from phenylalanine.

Keywords

Mammary Tumor L1210 Cell Test Substance Urea Concentration Thionyl Chloride

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Literature

1.
Brunner, H., Schmidt, M., Unger, G. and Schoenenberger H. Eur. J. Med. Chem. — Chim. Ther. 20:509-512, 1985.Google Scholar

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Authors and Affiliations

R. Voegeli
J. Pohl
P. Hilgard
J. Engel
W. Schumacher
H. Brunner
M. Schmidt
U. Holzinger
H. Schönenberger

There are no affiliations available